Article
Biochemistry & Molecular Biology
Beijun Cheng, Angel E. Kaifer
Summary: This study investigates the reaction between polyamines and carbon dioxide gas, revealing that the size of polyamine dendrimers plays a crucial role in determining the changes in the solution's physical properties. The reaction is reversible.
Article
Environmental Sciences
Rosario Planello, Roberto Rosal, Monica Aquilino, Oscar Herrero
Summary: The study assessed the toxicity of PAMAM dendrimers using a model insect, showing that G3-NH2 dendrimers induced more significant transcriptional alterations compared to G3-OH dendrimers, with both dendrimers producing persistent transcriptional changes even after compound withdrawal, with the lowest concentration being the most toxic. Additionally, both dendrimers demonstrated genotoxic effects on DNA.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Polymer Science
Anjara Morgado, Francisco Najera, Anna Lagunas, Josep Samitier, Yolanda Vida, Ezequiel Perez-Inestrosa
Summary: The study presents a novel synthesis method for preparing slightly sterically hindered amino terminal polyamide dendrimers. By utilizing an AB(2) scaffold and specific relative positions of amino groups, robust dendritic structures were successfully constructed and thoroughly characterized, demonstrating a substantial improvement in the preparation of stable dendrimers with high yield and simplified purification procedures.
Article
Chemistry, Multidisciplinary
Tao Zhou, Jianlei Qian, Xin Lu, Heng Xu, Lei Chen, Chuanlei Zhang
Summary: Two flexible ligands were used to construct a three-dimensional MOF with Co(NO3)(2)·6H(2)O, which was found to have a novel topological structure through analysis. The MOF was characterized by various methods and its properties were explored.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yanmiao Fan, Soumitra Mohanty, Yuning Zhang, Mads Luchow, Liguo Qin, Lisa Fortuin, Annelie Brauner, Michael Malkoch
Summary: Novel cationic hydrogels based on amino-functional hyperbranched dendritic-linear-dendritic copolymers exhibit excellent antimicrobial activity against a wide range of clinical bacteria, including drug-resistant strains. The hydrogels can induce the expression of antimicrobial peptides in human keratinocytes, reducing inflammation and promoting bacterial killing.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Polymer Science
R. M. England, S. Sonzini, D. Buttar, K. E. Treacher, M. B. Ashford
Summary: This study characterized poly(l-lysine) dendrimers using advanced analytical techniques and molecular dynamics simulations. The results showed an increase in refractive index and intrinsic viscosity in the early generations of the dendrimers, which decreased in later generations. The protected dendrimers had different molecular density profiles compared to the unprotected dendrimers, possibly due to electrostatic repulsion. This research provides valuable insights into the structure and properties of PLL dendrimers for drug delivery applications.
Article
Biochemistry & Molecular Biology
Khushbu Priyadarshi, Kavita Shirsath, N. Bhargav Waghela, Anupama Sharma, Ajay Kumar, Chandramani Pathak
Summary: The study focused on improving the efficacy of anti-cancer drugs by conjugating Gallic acid with PAMAM dendrimers. This conjugate showed increased activity in inhibiting cell proliferation, restricting cancer cell migration, and inducing apoptotic cell death.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Physical
Liping Luan, Bentian Tang, Songmei Ma, Lixiang Sun, Wenlong Xu, Aili Wang, Yuzhong Niu
Summary: Schiff base modified PAMAM dendrimer/silica hybrid materials were synthesized and used for removing aqueous Zn(II) and Ni(II). The study investigated the influence of various factors on the removal effect and revealed the interaction mechanism between adsorbents and metal ions through DFT calculation and XPS analysis. The results showed comparable adsorption properties for Zn(II) and Ni(II) and identified the key role of imino N atoms and carbonyl O atoms in the adsorption process.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Rashmi Kumar, Candace C. C. Liu, Sean C. Bendall, Michael Angelo
Summary: This study introduces a synthesis method of a dendrimer-based polymer and its application in MIBI-TOF tissue imaging. By comparing the staining performance of antibodies conjugated with dendrimers or linear polymers in FFPE tissue, it was found that dendrimers and linear polymers have comparable avidities. Moreover, dendrimers have advantages such as less background staining and no off-target binding in neural tissue. Overall, this research provides a versatile framework for using third-generation dendrimer-conjugated antibodies with improved staining compared to conventional linear polymers.
Article
Chemistry, Physical
Majid Jafari, Faramarz Mehrnejad, Reza Talandashti, Farahnoosh Doustdar, Mohammad Reza Vakili, Afsaneh Lavasanifar
Summary: This study simulated 15 molecular systems to characterize the interactions between PAMAM dendrimers and membranes with different cholesterol ratios, explaining the structural features and geometry of their activity against cancer cells. The results demonstrated that cholesterol content in the membranes influenced the local membrane order parameters, and the dendrimers were able to create holes in cholesterol-containing membranes through hydrogen bonds and electrostatic interactions. Additionally, negatively charged phospholipids in cancer cell membranes played a crucial role in binding with the dendrimers, providing mechanistic insight into their activity against cancer cells.
APPLIED SURFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kaiyan Wu, Bingxiang Wang, Ruyue Dou, Yiqun Zhang, Zhongxin Xue, Yongfeng Liu, Yuzhong Niu
Summary: A series of eco-friendly bioadsorbents were synthesized by decorating apple residue cellulose with different generation Schiff base functionalized PAMAM dendrimers. These bioadsorbents exhibit competitive adsorption capacity and remarkable selectivity for Hg(II) in the presence of other metal ions. They also show satisfactory adsorption performance in real water samples and can be regenerated for reuse. The adsorption mechanism involves the participation of functional groups OH, -CONH-, C-N, and N=C.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Mayk C. Ramos, Bruno A. C. Horta
Summary: The complexation of quercetin molecules with PAMAM dendrimers was studied, showing that different initial structures affect the convergence rate. Results suggest that quercetin molecules mainly interact with internal dendrimer monomers.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Review
Biochemical Research Methods
Dandan Guo, Xiaoqian Zhou, Nadeem Muhammad, Shaohua Huang, Yan Zhu
Summary: This article systematically summarizes the preparation and application of poly (amide-amine) functionalized separation materials. These materials have regular three-dimensional structures, abundant terminal groups, and unique cavity structures, which can have a positive impact on chromatographic separation materials. Poly (amide-amine) dendrimers exhibit high grafting efficiency, controllable surface structure, and good dispersion in separation materials.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Polymer Science
Juan Encalada-Alayola, Jorge A. Uribe-Calderon, Wilberth A. Herrera-Kao, Santiago Duarte-Aranda, Gerardo M. Alonzo-Medina, Ruben Dominguez-Maldonado, Jose Manuel Cervantes-Uc
Summary: The aim of this study was to investigate the potential of low-generation PAMAM dendrimers as drug nanocarriers for 5-FU and determine the most efficient generation type. PAMAM dendrimers (up to 2.0 generation) were synthesized and characterized, followed by successful incorporation of 5-FU. In vitro release studies showed that full-generation dendrimers exhibited the highest drug load capacity and slowest release rate, and the drug release kinetics were best described by the Korsmeyer-Peppas model. These results confirm the suitability of low-generation dendrimers as polymeric nanocarriers for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Kaiyan Wu, Bingxiang Wang, Bentian Tang, Liping Luan, Wenlong Xu, Beibei Zhang, Yuzhong Niu
Summary: A class of silica anchored Schiffbase decorated polyamidoamine (PAMAM) dendrimers were synthesized and used to remove aqueous Cu(II) and Ag(I). The adsorption performance and mechanism were investigated. The results showed that the adsorption capacity depended on dendrimer generation, solution pH, contact time, temperature, and initial metal ion concentration. The optimal adsorption pH was 6 for both metal ions. The adsorption kinetics followed a pseudo-second-order model, and film diffusion was the rate-controlling step. The adsorption isotherm indicated monolayer behavior with a chemical mechanism.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)