4.7 Article

Platinum(II)-catalyzed intermolecular hydroamination of monosubstituted allenes with secondary alkylamines

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CHEMICAL COMMUNICATIONS
卷 46, 期 10, 页码 1712-1714

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ROYAL SOC CHEMISTRY
DOI: 10.1039/b925859k

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  1. NIH [GM-080422]
  2. Pharmacological Sciences Training Program
  3. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM080422] Funding Source: NIH RePORTER

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A 1 : 1 mixture of (dppf)PtCl2 and AgOTf (5 mol%) catalyzed the intermolecular hydroamination of monosubstituted allenes with secondary alkylamines at 80 degrees C to form allylic amines in good yield with selective formation of the E-diastereomer.

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