Article
Multidisciplinary Sciences
Monica Fiorenza Boselli, Chiara Faverio, Elisabetta Massolo, Laura Raimondi, Alessandra Puglisi, Maurizio Benaglia
Summary: The development of new methods for introducing fluorine atoms or fluorinated moieties in molecular scaffolds is crucial in organic synthesis. The incorporation of the SCF3 group into organic molecules has shown beneficial effects on drug stability and bioavailability. By using a chiral auxiliary, enantioenriched alpha-SCF3-tetrasubstitued beta-keto esters can be synthesized in good yields with high enantioselectivity.
Article
Chemistry, Multidisciplinary
Zhi-Han Chen, Tian-Zhen Li, Ning-Yi Wang, Xiao-Fang Ma, Shao-Fei Ni, Yu-Chen Zhang, Feng Shi
Summary: This study introduces a novel strategy for the enantioselective synthesis of axially chiral N,N'-bisindoles using chiral phosphoric acid-catalyzed formal cycloadditions. The synthesized compounds showed excellent yields and enantioselectivities, and exhibited cytotoxicity towards cancer cells. Moreover, they were also transformed into axially chiral phosphine ligands with high catalytic activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kazutaka Shibatomi
Summary: This paper summarizes our recent efforts in the enantioselective organocatalytic synthesis of chiral halogenated compounds. The discussion includes enantioselective alpha-halogenation of aldehydes, decarboxylative chlorination of beta-keto acids, and enantioselective C-C bond formation at the trifluoromethylated prochiral carbon to yield organohalides with chlorinated, fluorinated, or trifluoromethylated chiral stereogenic centers. Common organocatalysts such as Jorgensen-Hayashi catalyst and cinchona alkaloid-derivatived catalyst were applied, and novel chiral amine catalysts were developed for these reactions. Stereospecific derivatizations of the chiral halogenated compounds via nucleophilic substitution are also discussed, resulting in the synthesis of many novel chiral compounds that have not been reported before, even as racemates.
Review
Chemistry, Organic
Thien T. Nguyen
Summary: Asymmetric organocatalysis is an important method for synthesizing axially chiral tetrasubstituted allenes, with the ability to achieve regio- and stereoselectivity through remote control. This method enables the efficient preparation of highly functionalized enantiopure allenes and finds broad applications in the synthesis of novel ligands, natural products, and organic materials.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Banni Preet Kaur, Vivek Sharma, Subash Chandra Sahoo, Swapandeep Singh Chimni
Summary: Enantiopure bis-heterocyclic molecules containing pyrazole and isoxazole were synthesized via a low-catalyst loading Michael addition reaction under mild conditions with high yields and enantiomeric excess. These derivatives can be further transformed into potentially bio-active molecules with significant applications. The synthesis of these bis-heterocyclic molecules can be efficiently carried out in one pot without any loss of enantiopurity, adding to their significance.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jia-Hong Wu, Siqiang Fang, Xingtao Zheng, Jiajia He, Yi Ma, Zhishan Su, Tianli Wang
Summary: Efficient and practical methodology has been developed for building two types of phosphorus-installing helicenes via the phosphonium salt catalyzed phospha-Michael reaction together with copper salt enabled aromatization. The scalability and practicality of this protocol were validated by the gram-scale synthesis and transformation of products, particularly towards producing novel helical phosphine ligands that were successfully utilized in metal-catalyzed reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Xin-Yue Qu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, Shu-Yu Zhang
Summary: In this study, the direct enantioselective synthesis of chiral aza-quaternary carbon indolenines was achieved through catalytic asymmetric strategy, and its potential in drug molecule modification was demonstrated.
Article
Chemistry, Organic
Alemayehu Gashaw Woldegiorgis, Zhao Han, Xufeng Lin
Summary: The highly regio-, diastereo-, and enantioselective dearomatization reaction of 1-substituted 2-naphthols and beta,gamma-alkynyl-alpha-imino esters with complete atom economy is disclosed via chiral phosphoric acid catalysis. This protocol provides facile and efficient access to asymmetric construction of axially chiral allene-derived naphthalenones bearing quaternary stereocenters in good yields with high diastereoselectivities and enantioselectivities.
Article
Chemistry, Multidisciplinary
Tao Wang, Xiao-Yan Zhang, Yu-Cong Zheng, Yun-Peng Bai
Summary: A carbonyl reductase variant, SmCRM5, obtained from Serratia marcescens through structure-guided directed evolution, showed improved specific activity towards multiple substrates and high stereoselectivities in the asymmetric synthesis of gamma-/delta-lactones.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Akram Hussain, Dhevalapally B. Ramachary
Summary: We developed a simple and practical protocol for the chemoselective coupling of optically active functionally rich 2-aroylcyclopropanecarbaldehydes with various CH acids or active methylene compounds. This metal-free, organocatalytic selective reductive C-C coupling method offers advantages such as no epimerization, no ring opening, high carbonyl control, and large substrate scope. The resulting chiral products can serve as building blocks for the synthesis of value-added small molecules, natural products, pharmaceuticals, and their analogues.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
William R. Cassels, Jennifer L. Fulton, Jeffrey S. Johnson
Summary: Enantioconvergent iso-Pictet-Spengler reactions of chiral racemic ss-formyl esters and a ss-keto ester are reported, leading to the formation of complex tetrahydro-& gamma;-carbolines bearing two contiguous stereocenters. These reactions are catalyzed by a chiral thiourea and benzoic acid cocatalytic system, representing unusual nonhydrogenative stereoconvergent additions to racemic & alpha;-stereogenic-ss-dicarbonyls. The transformation of the products to chiral aminoalcohols and carbamates is also demonstrated.
Article
Chemistry, Multidisciplinary
Ke-Wei Chen, Zhi-Han Chen, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy has been developed for the highly atroposelective synthesis of N-N axially chiral indole scaffolds and bispyrroles, which can be used as chiral organocatalysts and exhibit potent anticancer activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Meng-Yu Rong, Jing Nie, Shen Li, Jun-An Ma
Summary: We synthesized a new class of chiral quaternary ammonium salts and used them as catalysts in phase-transfer catalytic asymmetric alkylation. By employing these catalysts, we obtained a series of chiral fluorinated aromatic alpha-amino acid derivatives with high yields and enantioselectivities.
MOLECULAR CATALYSIS
(2024)
Review
Chemistry, Physical
Miguel Sanchez-Fuente, Jose Lorenzo Alonso-Gomez, Laura M. Salonen, Ruben Mas-Balleste, Alicia Moya
Summary: This review provides an overview of the development of chiral porous organic frameworks as candidates for heterogeneous asymmetric organocatalysis. The synthetic strategies, characterization techniques, and applications of chiral organic materials in asymmetric organocatalysis are summarized. Various types of porous organic frameworks are described, and strategies for incorporating chirality in these materials are presented. The review focuses on the applications of chiral porous organic frameworks in asymmetric organocatalytic reactions, summarizing and categorizing the available literature in the field.
Article
Chemistry, Organic
Yuichiro Kawamoto, Naoki Noguchi, Daiki Ozone, Toyoharu Kobayashi, Hisanaka Ito
Summary: Chiral quaternary carbon-containing bicyclic compounds with carbonyl functionalities were efficiently synthesized through asymmetric intramolecular aldol reactions using organocatalysts. Different types of catalysts were used to construct different bicyclic systems.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Minli Zhang, Tong Li, Chaoxing Cui, Xixi Song, Junbiao Chang
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Computer Science, Software Engineering
Haitao Zhang, Chenguang Yu, Yan Jin
INTERNATIONAL JOURNAL OF DATA WAREHOUSING AND MINING
(2020)
Article
Critical Care Medicine
Chen Guang Yu, Vimala Bondada, Aashish Joshi, Dexter V. Reneer, Glenn C. Telling, Kathryn E. Saatman, James W. Geddes
JOURNAL OF NEUROTRAUMA
(2020)
Article
Chemistry, Organic
Chenguang Yu, Peng Ji, Yueteng Zhang, Xiang Meng, Wei Wang
Summary: This method utilizes a cascade cocatalysis strategy to achieve the easy construction of chiral gamma, gamma-disubstituted butenolides, showing good generality and effectiveness.
Article
Biochemistry & Molecular Biology
Chen Guang Yu, Vimala Bondada, Hina Iqbal, Kate L. Moore, John C. Gensel, Subbarao Bondada, James W. Geddes
Summary: BTK activation plays a crucial role in the neuroimmune response after traumatic spinal cord injury. Inhibiting BTK activity with Ibrutinib can attenuate the neuroimmune cascade and improve locomotor recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Qianqian Li, Xiaofan Zhu, Chenguang Yu, Lin Shang, Ranran Li, Xia Wang, Yaping Yang, Jingjing Meng, Xiangdong Kong
Summary: This study describes a case of external ophthalmoplegia with rib and vertebral anomalies (EORVA) in an 8-year-old boy. A novel homozygous mutation in the myogenic factor 5 gene (MYF5) was identified using trio-based exome sequencing. Functional experiments showed that the mutant MYF5 led to decreased expression and production of a truncated protein.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Qianqian Li, Zhanni Chen, Hui Xiong, Ranran Li, Chenguang Yu, Jingjing Meng, Panlai Shi, Xiangdong Kong
Summary: This paper presents a case study of a 10-year-old boy diagnosed with Duchenne muscular dystrophy (DMD), confirming a large partial exonic deletion through whole exome sequencing. It highlights the clinical importance of using multiple molecular genetic testing methods for the diagnosis of rare diseases.
FRONTIERS IN GENETICS
(2021)
Article
Andrology
Yuanyuan Zhao, Yang Fan, Mengru Wang, Chenguang Yu, Mengchen Zhou, Dan Jiang, Dunfeng Du, Shanshan Chen, Xin Tu
Summary: This study using Mendelian randomization found that genetic predisposition to KSD could increase the risk of coronary atherosclerosis and cardiomyopathy, while hypertension could increase the risk of developing KSD.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qianqian Li, Ziguan Zhang, Shanshan Chen, Zhengrong Huang, Mengru Wang, Mengchen Zhou, Chenguang Yu, Xiangyi Wang, Yilin Chen, Dan Jiang, Dunfeng Du, Yufeng Huang, Xin Tu, Zhishui Chen, Yuanyuan Zhao
Summary: The study demonstrated the role of miR-190a-5p in regulating IL-2 and SCN3B in the progression of CAs, suggesting miR-190a-5p as a potential protective factor in the pathogenesis of CAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Correction
Critical Care Medicine
Chen Guang Yu, Kate L. Moore
JOURNAL OF NEUROTRAUMA
(2022)
Meeting Abstract
Critical Care Medicine
Chen-Guang Yu, James Geddes
JOURNAL OF NEUROTRAUMA
(2021)
Article
Chemistry, Organic
Wen-Bo Hu, Xixi Song, Min-Can Wang
Summary: A new asymmetric activation strategy is developed for hydrazones as acyl anion equivalents in the bimetallic catalyzed carbonyl-ene reaction, resulting in high yields and high enantioselectivity. By utilizing a Bronsted base, formaldehyde tert-butylhydrazone can be well activated in this process.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Computer Science, Information Systems
Guangyu Li, Lina Qiu, Chenguang Yu, Houwei Cao, Yong Liu, Can Yang
Summary: Using a large IPTV dataset, this paper analyzes channel zapping behaviors of IPTV users to generate more accurate channel zapping recommendations. A deep neural network model, consisting of a Recommender System Attention module and a Channel Attention module, is developed to further improve recommendation accuracy.
IEEE TRANSACTIONS ON MULTIMEDIA
(2021)
Article
Chemistry, Organic
Tong Li, Dandan Yan, Chaoxing Cui, Xixi Song, Junbiao Chang
ORGANIC CHEMISTRY FRONTIERS
(2020)
Article
Multidisciplinary Sciences
Emily N. Chin, Chenguang Yu, Vincent F. Vartabedian, Ying Jia, Manoj Kumar, Ana M. Gamo, William Vernier, Sabrina H. Ali, Mildred Kissai, Daniel C. Lazar, Nhan Nguyen, Laura E. Pereira, Brent Benish, Ashley K. Woods, Sean B. Joseph, Alan Chu, Kristen A. Johnson, Philipp N. Sander, Francisco Martinez-Pena, Eric N. Hampton, Travis S. Young, Dennis W. Wolan, Arnab K. Chatterjee, Peter G. Schultz, H. Michael Petrassi, John R. Teijaro, Luke L. Lairson
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
