Article
Chemistry, Physical
Goknur Yasa Atmaca, Fikriye Tuncel Elmali, Ali Erdogmus
Summary: Sono-photodynamic study is a promising alternative method for cancer treatment, surpassing photodynamic study in terms of therapeutic outcome. However, there is a lack of related studies in the literature. This study aimed to design and synthesize a suitable sono-photosensitizer by substituting a ruthenium (II) complex with silicon phthalocyanine, and to increase singlet oxygen production using sono-photochemical studies. The results demonstrated an improved singlet oxygen generation with the substituent group and approximately two-fold increase in yield with the sono-photochemical method. This article will contribute to future research on improving sono-photochemical properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Plant Sciences
Jing-Jing Wu, Jia Zhang, Cong-Yuan Xia, Kang Ding, Xin-Xin Li, Xue-Ge Pan, Jie-Kun Xu, Jun He, Wei-Ku Zhang
Summary: This review provides a comprehensive summary and analysis of the extensive pharmacological applications of hypericin. By reviewing the literature, it presents conclusions on the natural and artificial sources of hypericin, strategies to improve its bioactivity, pharmacological activities, and drug combinations, and explores the future therapeutic potential of this active compound.
Article
Chemistry, Physical
Halise Yalazan, Burak Barut, Sercan Yildirim, Can Ozgur Yalcin, Halit Kantekin
Summary: In this study, axially different isoxazolyl disubstituted silicon (IV) phthalocyanines were synthesized and their interactions with DNA were investigated. One of the compounds showed the strongest interaction with DNA and exhibited higher phototoxicity on cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Pharmacology & Pharmacy
Dongqin Xia, Wenjie Li, Ce Tang, Juan Jiang
Summary: Cancer is increasing in developing countries with unsatisfactory outcomes from traditional cancer treatments. Traditional Chinese medicine (TCM) components, such as Astragaloside IV (AS-IV), have shown significant anticancer activities. AS-IV has various effects, including modulation of enzyme activities, cell cycle arrest, apoptosis and autophagy induction, and suppression of cancer progression. This article reviews the bioavailability, anticancer activity, and mechanism of AS-IV and provides suggestions for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Siqi Xiao, Zehua Lu, Jianmin Yang, Xianai Shi, Yunquan Zheng
Summary: In this study, researchers found that the phycocyanobilin compound in phycocyanin can be used as a new anticancer photosensitizer with anti-inflammatory and immunomodulatory activities. The compound was produced rapidly with high purity and showed significant anticancer activity under light conditions. Its active oxygen quantum yield was much higher than that of chlorophyll, making it a promising candidate for cancer treatment.
Article
Chemistry, Multidisciplinary
Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang, Jun-Jie Zhu, Zhen Gu
Summary: The lipid droplets in adipocytes have been demonstrated to be a controllable and biocompatible vehicle for delivering anticancer drugs, enhancing the therapeutic effect of cancer photodynamic therapy through various pathways. Loading a lipid-conjugated photosensitizer into the lipid droplets reduces its IC50 value by 6.0-fold. In vivo results show that engineered lipid droplets effectively inhibit tumor growth with minimal side effects.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Nisa Kayir, Semih Gorduk
Summary: Phthalocyanines, a derivative of macro heterocyclic compound, can be used in various industrial and scientific areas by adding different substituents to the phthalocyanine ring. In this study, Silicon(IV) phthalocyanine was synthesized with 2-hydroxymethyl-1,4-benzodioxan as a substituent to provide solubility in organic solvents. The newly synthesized substance showed significant singlet oxygen quantum yields, making it a potential photosensitizer in photodynamic therapy (PDT) for cancer.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Oncology
Ceren Sari, Ismail Degirmencioglu, Figen Celep Eyupoglu
Summary: This study investigates the anticancer effects of newly synthesized silicon phthalocyanine (SiPc) molecules on breast cancer cell lines and a non-tumorigenic breast cell line through photodynamic therapy (PDT). The SiPc molecules were synthesized and characterized, and their cytotoxic effects, apoptotic cell death, mitochondrial membrane potential, intracellular ROS generation, clonogenic activity, cell motility, migration, and invasion capacities were analyzed.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wenyi Dong, Ke Li, Shijie Wang, Ling Qiu, Qingzhu Liu, Minhao Xie, Jianguo Lin
Summary: The study presents a novel photosensitizer compound 1 targeted at biotin receptors, demonstrating promising therapeutic effects on biotin receptor-positive tumors. Compound 1 selectively accumulates in A549 cells and shows anti-tumor activity in vivo, indicating potential applications in clinical PDT for lung cancers.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zixuan Chen, Yuan-Yuan Zhao, Li Li, Ziqing Li, Shuwen Fu, Yihui Xu, Bi-Yuan Zheng, Meirong Ke, Xingshu Li, Jian-Dong Huang
Summary: In this study, we synthesized two zinc(II) phthalocyanines monosubstituted with a sulphonate group, which exhibited highly efficient production of superoxide radical (O-2(center dot-)) and singlet oxygen (O-1(2)) under light irradiation. The liposomal nanophotosensitizer showed selective accumulation in tumors and significant tumor inhibition effects.
Article
Oncology
Pelin Balcik-Ercin, Gulcin Ekineker, Nazli Salik, Bahar Aydogdu, Tamer Yagci, Meltem Goksel
Summary: In this study, a new SiPc derivative conjugated with arginine was synthesized for use as a phthalocyanine-based photosensitizer in photodynamic therapy (PDT) applications. The resulting conjugate, PS-5a, was thoroughly characterized using various spectroscopic techniques and found to have significant cytotoxic effects on cancer cells.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hueseyin Bas, Zekeriya Biyiklioglu, Burak Barut, Can Ozgur Yalcin, Arzu Ozel
Summary: Photodynamic therapy (PDT) is a growing clinical approach used to treat life-threatening diseases such as cancer. This study evaluated the in vitro effect of silicon(IV) phthalocyanine, naphthalocyanine, and their water-soluble derivatives as potential photosensitizers for PDT. The compounds were characterized and their interaction with ct-DNA was investigated. The cytotoxic/phototoxic effects of the compounds on cancer cells were evaluated, and 3a showed the highest cytotoxic and phototoxic effects. In conclusion, 3a could be an effective photosensitizer agent for PDT.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Ai-Lan Lin, Jia-Hui Chen, Jie-Wei Hong, Yuan-Yuan Zhao, Bi-Yuan Zheng, Mei-Rong Ke, Jian-Dong Huang
Summary: This study developed a highly efficient nanophotosensitizer NanoPcN-FA for photodynamic therapy, which demonstrated targeted effects on SKOV3 cells and efficient antitumor efficacy in vivo, with a tumor inhibition rate of 95%. Competitive assays confirmed the FR-mediated cellular uptake process of NanoPcN-FA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Wenling Xiao, Xinqiao Guan, Bingcheng Huang, Qiuhao Ye, Tiantian Zhang, Kuizhi Chen, Yiru Peng, Fangmeng Fu
Summary: Two series of fluorinated and non-fluorinated dendritic silicon (IV) phthalocyanines with terminal functionalities were synthesized and encapsulated into nanoparticles using an amphiphilic diblock copolymer. The effects of fluorinated groups and terminal functionalities on the photo physical properties and DNA photocleavage activities were studied through various spectroscopic methods, providing insights into their potential applications in biomedicine.
Article
Chemistry, Analytical
Haidi Yin, Jianhui Zhu, Mengmeng Wang, Zhong-Ping Yao, David M. Lubman
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Jianhui Zhu, Junfeng Huang, Jie Zhang, Zhengwei Chen, Yu Lin, Gabriela Grigorean, Lingjun Li, Suyu Liu, Amit G. Singal, Neehar D. Parikh, David M. Lubman
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Andriy Myronovych, Bailey C. E. Peck, Mingrui An, Jianhui Zhu, Anna Warm, Aleksander Kupe, David M. Lubman, Randy J. Seeley
Summary: The study revealed that extracellular vesicles in the intestines of mice after VSG were enriched, with a significantly different protein composition compared to before VSG. VSG-derived extracellular vesicles exhibited cytotoxic effects on intestinal epithelial cells and reduced proliferation of intestinal progenitor cells in mice.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemical Research Methods
Xiaohui Ji, Sisi Huang, Jie Zhang, Terri F. Bruce, Zhijing Tan, Donglin Wang, Jianhui Zhu, R. Kenneth Marcus, David M. Lubman
Summary: A rapid, low-cost, and simple separation strategy has been developed to isolate extracellular vesicles from small serum samples with minimal contamination, achieving high purity for EV proteome analysis. The method utilizes a PET C-CP fiber phase/HIC approach for EV separation and a post-column cleanup protocol to eliminate non-EV proteins, resulting in successful isolation of exosome-like particles with high yield in approximately 15 minutes. This methodology addresses major challenges in EV separation for proteomics analysis and has the potential to be combined with other techniques for further purification.
Article
Multidisciplinary Sciences
Orawan Jakdetchai, Peter Eberhardt, Marvin Asido, Jagdeep Kaur, Clara Nassrin Kriebel, Jiafei Mao, Alexander J. Leeder, Lynda J. Brown, Richard C. D. Brown, Johanna Becker-Baldus, Christian Bamann, Josef Wachtveitl, Clemens Glaubitz
Summary: This study on the functional mechanism of the light-driven sodium pump KR2 uses solid-state nuclear magnetic resonance spectroscopy to reveal the interconversion of photointermediates and the perturbation caused by the nearby bound sodium ion. The findings suggest a mechanism different from traditional principles, highlighting the importance of understanding the role of sodium ion in retinal conformation changes.
Article
Biochemical Research Methods
Rui Zhang, Jianhui Zhu, David M. Lubman, Yehia Mechref, Haixu Tang
Summary: Glycosylation is a common post-translational modification in proteins, and LC-MS/MS and EThcD are commonly used for glycoprotein analysis. The GlycoHybridSeq software can automatically interpret EThcD-MS/MS spectra in glycoproteomic data using a customized scoring function.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemical Research Methods
Jianhui Zhu, Jie Zhang, Xiaohui Ji, Zhijing Tan, David M. Lubman
Summary: A column-based CD9-antibody-immobilized high-performance liquid chromatography immunoaffinity chromatography (CD9-HPLC-IAC) technology was developed for efficient isolation and proteomic characterization of EVs from a microscale volume of serum. The method achieved EV isolation within 30 minutes with a high yield, and significantly reduced contamination of blood proteins and lipoprotein particles compared to traditional methods.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cristian D. Gutierrez Reyes, Yifan Huang, Mojgan Atashi, Jie Zhang, Jianhui Zhu, Suyu Liu, Neehar D. Parikh, Amit G. Singal, Jianliang Dai, David M. Lubman, Yehia Mechref
Summary: The study utilized LC-PRM-MS method to identify significant differences in glycosylation of serum haptoglobin between cirrhosis and hepatocellular carcinoma, providing a new approach for diagnosis. Combinations of specific N-glycopeptides can better estimate the area under ROC curves, outperforming AFP alone in performance evaluation.
Article
Multidisciplinary Sciences
Danhua Dai, Xianwei Wang, Yiwei Liu, Xiao-Liang Yang, Clemens Glaubitz, Vasyl Denysenkov, Xiao He, Thomas Prisner, Jiafei Mao
Summary: Dynamic nuclear polarization (DNP) significantly enhances NMR sensitivity, but its application in aqueous solutions is difficult. In this study, researchers demonstrate substantial enhancement of carbon polarization in small biomolecules in water at room temperature and high magnetic field using in situ Overhauser DNP.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yu Lin, Jianhui Zhu, Jie Zhang, Jianliang Dai, Suyu Liu, Ana Arroyo, Marissa Rose, Amit G. Singal, Neehar D. Parikh, David M. Lubman
Summary: Nonalcoholic steatohepatitis (NASH) is the fastest growing cause of hepatocellular carcinoma (HCC) in the United States. Changes in N-glycosylation on specific glycosites of serum proteins have been investigated as potential markers for the early detection of NASH-related HCC. A glycopeptide with a Sialyl Lewis structure derived from serum haptoglobin (Hp) has been identified as a potential marker for NASH related HCCs. The combination of N241_A4G4F2S4 and alpha-fetoprotein (AFP) showed improved performance for HCC detection compared to AFP alone.
Article
Chemistry, Multidisciplinary
Jianhui Zhu, Zhijing Tan, Jie Zhang, Mingrui An, Valerie M. Khaykin, Kyle C. Cuneo, Neehar D. Parikh, David M. Lubman
Summary: Circulating tumor cells (CTCs) and exosomes released from primary tumors into the blood can serve as potential cancer biomarkers for diagnosis and monitoring. This study developed an integrated system to sequentially isolate CTCs and exosomes from a single blood sample, allowing further profiling and analysis. The CTCs were identified using fluorescence staining, while the exosomes were analyzed using advanced techniques such as transmission electron microscopy and mass spectrometry. The results showed the potential of using CTCs for the detection of metastatic hepatocellular carcinoma (HCC) and the identification of cancer-related proteins in exosomes.
Article
Multidisciplinary Sciences
Sha Zhao, Xinming Li, Ziyang Wen, Mengbing Zou, Ge Yu, Xiangyang Liu, Jiafei Mao, Lixin Zhang, Yi Xue, Riqiang Fu, Shenlin Wang
Summary: Base pairs are essential units in RNA and their stability plays a crucial role in RNA functions. A solid-state NMR-based water-RNA exchange spectroscopy technique was developed to evaluate base pair stability. By applying this technique to a specific RNA complex, it was found that the U47.U51 base pair has low stability, indicating its involvement in the early stage of ligand release.
Article
Chemistry, Multidisciplinary
Yifei Tan, Jianhui Zhu, Cristian D. Gutierrez Reyes, Yu Lin, Zhijing Tan, Zuowei Wu, Jie Zhang, Alva Cano, Sara Verschleisser, Yehia Mechref, Amit G. Singal, Neehar D. Parikh, David M. Lubman
Summary: Aberrant changes in site-specific core fucosylation (CF) of serum proteins can serve as potential diagnostic markers of tumors. A study employed an optimized data-dependent acquisition (DDA) workflow to identify CF of serum proteins in patients with nonalcoholic steatohepatitis-related cirrhosis and hepatocellular carcinoma. The study found significant changes in CF peptides between cirrhosis and HCC, with one peptide showing the best diagnostic performance in discriminating HCC from cirrhosis.
Article
Anesthesiology
Yangmiao Zhang, Wentai Luo, Mary M. Heinricher, Andrey E. Ryabinin
Summary: Social interactions can increase nociceptive sensitivity, and olfactory cues can induce nociceptive hypersensitivity in untreated animals. This study demonstrated that inflammatory pain can modulate nociception in bystander mice via olfactory mechanisms. Volatile compounds in mouse bedding can indicate disease states.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Chemistry, Multidisciplinary
Yu Lin, Jianhui Zhu, Jie Zhang, Jianliang Dai, Suyu Liu, Ana Arroyo, Marissa Rose, Amit G. Singal, Neehar D. Parikh, David M. Lubman
Summary: A glycopeptide with a Sialyl Lewis structure derived from serum haptoglobin has been identified as a potential marker for NASH-related HCC. When combined with alpha-fetoprotein (AFP), it showed improved detection performance for HCC.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
