Article
Biochemistry & Molecular Biology
Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning
Summary: Phosphodiesterase-5 inhibitors (PDE5i) are being studied for their potential in preventing colon cancer. However, their side-effects and interactions with other drugs have been a concern. By modifying the prototypical PDE5i sildenafil, we developed a new analog called malonyl-sildenafil which exhibited reduced lipophilicity and showed promising effects on colon epithelium. This analog suppressed proliferation in the colon epithelium, providing a novel approach to developing a first-in-class drug for colon cancer chemoprevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Ying Yu, Xiaodan Wang, Mingyang Li, Dengyong Liu
Summary: An electrochemical platform based on a novel ternary nanocomposite glassy carbon electrode modified with gold nanoparticles, Ru(bpy)2Cl2, and SMWCNTs is developed for the detection of 5'-GMP. The optimized conditions for the electrochemical sensor include acidic media, which provide high specificity, sensitivity, and selectivity. The sensor exhibits a wide linear range and enhanced sensitivity attributed to the conductivity and electrocatalytic properties of Ru(bpy)2Cl2 and functionalized SMWCNTs. The precise analysis of 5'-GMP in actual broth samples shows satisfactory recovery, making this sensor suitable for market and food enterprises.
Article
Electrochemistry
Yang Huang, Tianyi Gao, Chong Sun, Tingting Han, Mingwu Zang, Daoying Wang, Weimin Xu
Summary: In this study, a novel electrochemical platform based on a ternary nanocomposite of Au-PPy@g-C3N4 was designed for the detection of GMP. The platform showed a linear range, low detection limit, and exhibited stability and anti-interference ability.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Applied
Oswaldo Perez, Nicolaas Schipper, Martin Bollmark
Summary: The synthesis of the cyclic guanosine monophosphorothioate analogue 1a was achieved through a diastereoselective route, utilizing a silyl protection sequence to achieve high selectivity for the desired product. This chromatography-free process allowed for a successful scale-up production of the compound.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Applied
Dongyan Yu, Wenting Deng, Xueqin Wei
Summary: A fluorescent supramolecular aggregate 1, synthesized by self-assembly of pillar [5]arene-based Cu(II) coordination complexes, was characterized using various spectroscopic and microscopic techniques. The aggregate exhibited high sensitivity and selectivity toward nitroaromatic compounds and metal ions, particularly p-nitrophenol and Fe3+, with low detection limits. The possible mechanisms of fluorescence quenching were discussed and the method was successfully applied for detecting PNP and Fe3+ in lake water.
Article
Chemistry, Organic
Rajesh Sahu, Saurav Yadav, Krishna Chaitanya Gunturu, Anant R. Kapdi
Summary: Sensing important metals in different environments is vital, and the use of fluorescent sensors in metal sensing is a widely applied method. This study introduces a phenothiazine-based fluorescent sensor for Cu(II) ions, which shows high selectivity compared to other transition metal salts. The Lewis acidity of the Cu(II) salt and a 1:1 ratio were found to enhance the sensing response in MeOH solvent.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Guangshuo Zhu, Kazutaka Ueda, Masaki Hashimoto, Manling Zhang, Masayuki Sasaki, Taro Kariya, Hideyuki Sasaki, Nina Kaludercic, Dong-Ik Lee, Djahida Bedja, Matthew Gabrielson, Yuan Yuan, Nazareno Paolocci, Robert M. Blanton, Richard H. Karas, Michael E. Mendelsohn, Brian O'Rourke, David A. Kass, Eiki Takimoto
Summary: This study found that PDE5i improves heart failure by activating the PKG-PGC1 alpha axis, which enhances mitochondrial respiration and upregulates PGC1 alpha mRNA. However, the cardioprotective effects of PDE5i were abolished in hearts lacking the PGC1 alpha gene.
Review
Medicine, Research & Experimental
Wesam S. Ahmed, Anupriya M. Geethakumari, Kabir H. Biswas
Summary: Phosphodiesterase 5 (PDE5) is a well-studied enzyme that targets cGMP, with therapeutic applications for erectile dysfunction and pulmonary arterial hypertension. Understanding the interaction of PDE5 inhibitors with PDE5 and their structural basis of selectivity is crucial for designing novel drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Analytical
Xiaoyue Zhang, Xuan Kuang, Xiang Ren, Yuewei Wang, Xuejing Liu, Yueyun Li, Huangxian Ju, Qin Wei
Summary: This study introduces a novel supramolecular anchoring strategy to create stable copper nanoclusters (CET-Cu NCs) with remarkable electrochemiluminescence (ECL) properties. CET-Cu NCs exhibit high ECL efficiency and can generate ECL emission through multiple paths, enhancing the reliability and robustness of sensing and analytical systems. By utilizing oriented immobilization technology and antibody/aptamer sandwich assays, CET-Cu NCs are successfully applied as ECL signal probes for ultrasensitive detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Keshab Kumar Karna, Bo-Ram Choi, Chul-Young Kim, Hye-Kyung Kim, Jong-Kwan Park
Summary: This study found that Rubus occidentalis and ellagic acid can induce relaxation of rabbit penile corpus cavernosum smooth muscle by activating the nitric oxide signaling pathway, which may improve erectile function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Article
Biochemistry & Molecular Biology
Liming Hu, Yifan Lin, Peng Wang, Hongsheng Zhang, Minyao Liu, Shanyan Mo
Summary: The authors report a near-infrared fluorescent probe for highly sensitive detection of Cu(II) ions in organisms. The probe demonstrates sensitive, specific, and fast response, with a good linear relationship between concentration and fluorescence intensity.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Chemistry, Multidisciplinary
Erting Feng, Yuhan Liu, Shibo Lv, Dapeng Liu, Shuheng Huang, Zhiliang Li, Fengling Song
Summary: A self-assembly fine-tuning strategy based on organic-metal coordination interaction is proposed to adjust the aggregated morphology of near-infrared dyes. The study demonstrates the superior photothermal performance of H-type aggregates formed by the specific Cy-3COOH/Cu coordination.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Microbiology
Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong
Summary: This study found that Brucella outer membrane protein Omp25 could suppress the production of IFN-beta and its downstream IFN-stimulated genes induced by various DNA viruses or IFN-stimulatory DNA. Omp25 promoted the degradation of cyclic GMP-AMP synthase (cGAS) via the ubiquitin-proteasome-dependent pathway, leading to the inhibition of IFN-beta induction in various mammalian monocyte/macrophages.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Erika Kozma, Antonella Caterina Boccia, Anita Andicsova-Eckstein, Alfio Pulvirenti, Chiara Botta
Summary: The selective detection of metal ions in water using sustainable detection systems is crucial for monitoring water environments and ensuring drinking water safety. In this study, a low-cost, water-soluble potassium salt of PTAS was designed and synthesized, exhibiting a selective optical response to Cu2+ and Pb2+ ions in aqueous solutions. The use of a water-soluble chromophore and efficient analyte-probe interactions enabled sensitive detection of copper ions in drinking water and lead ions in waste water, providing a basis for sustainable sensing systems.
Article
Chemistry, Multidisciplinary
Prakash P. Neelakandan, Azucena Jimenez, John D. Thoburn, Jonathan R. Nitschke
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Review
Chemistry, Multidisciplinary
Anna J. McConnell, Christopher S. Wood, Prakash P. Neelakandan, Jonathan R. Nitschke
Article
Chemistry, Physical
Krishnankutty S. Sanju, Shameel Thurakkal, Prakash P. Neelakandan, Joshy Joseph, Danaboyina Ramaiah
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2015)
Article
Chemistry, Multidisciplinary
Andrew J. Musser, Prakash P. Neelakandan, Johannes M. Richter, Hirotaka Mori, Richard H. Friend, Jonathan R. Nitschke
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Khalid Naim, Sreejisha T. Nair, Pranjali Yadav, Asifkhan Shanavas, Prakash P. Neelakandan
Article
Chemistry, Multidisciplinary
Sanchita Shah, Ashima Bajaj, Abhishek Shibu, Md. Ehesan Ali, Prakash P. Neelakandan
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Prakash P. Neelakandan, Azucena Jimenez, Jonathan R. Nitschke
Article
Chemistry, Multidisciplinary
Prakash P. Neelakandan, Tarek A. Zeidan, Martin McCullagh, George C. Schatz, Josh Vura-Weis, Chul Hoon Kim, Michael R. Wasielewski, Frederick D. Lewis
Article
Chemistry, Multidisciplinary
Parvati Marandi, P. P. Praveen Kumar, Paloth Venugopalan, Prakash P. Neelakandan
Article
Chemistry, Multidisciplinary
Atikur Rahman, Priyanka Sharma, Navneet Kaur, Asifkhan Shanavas, Prakash P. Neelakandan
Article
Chemistry, Multidisciplinary
Khalid Naim, Manjeet Singh, Sachin Sharma, Rajesh Nair, Paloth Venugopalan, Subash Chandra Sahoo, Prakash P. Neelakandan
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
P. P. Praveen Kumar, Atikur Rahman, Tanmay Goswami, Hirendra N. Ghosh, Prakash P. Neelakandan
Summary: The study presents supramolecular nanocomposites composed of BODIPY, tryptophan, and gold nanoparticles, showing that the photostability and photosensitization properties of the nanocomposites are influenced by the chemical composition of the BODIPY molecules. Structural variations in BODIPY molecules impact the singlet oxygen quantum yield of the nanocomposites, with a higher efficiency observed when compared to individual components. Ultrafast spectroscopy studies reveal efficient generation of singlet oxygen through electron transfer from photoexcited BODIPY to plasmonic photoexcitation.
Article
Chemistry, Analytical
P. P. Praveen Kumar, Navneet Kaur, Asifkhan Shanavas, Prakash P. Neelakandan
Article
Chemistry, Multidisciplinary
P. P. Praveen Kumar, Pranjali Yadav, Asifkhan Shanavas, Prakash P. Neelakandan
MATERIALS CHEMISTRY FRONTIERS
(2020)
Article
Chemistry, Multidisciplinary
P. P. Praveen Kumar, Pranjali Yadav, Asifkhan Shanavas, Shameel Thurakkal, Joshy Joseph, Prakash P. Neelakandan
CHEMICAL COMMUNICATIONS
(2019)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
