Article
Biochemistry & Molecular Biology
Urszula Bachor, Agnieszka Lizak, Remigiusz Bachor, Marcin Maczynski
Summary: Hybrid peptides composed of alpha and beta-amino acids have potential as therapeutic agents. Therefore, the development of new unnatural amino acids and methods for their incorporation is important. In this study, we investigated the application of 5-amino-3-methyl-isoxazole-4-carboxylic acid (AMIA) in solid phase peptide synthesis. The results show that this unnatural beta-amino acid can be used in synthesizing a new class of bioactive peptides.
Article
Chemistry, Organic
Sunglim Choi, Jihyun Shim, Philjae Kang, Soo Hyuk Choi
Summary: The study demonstrates that using cis-4-aminopiperidine-3-carboxylic acid (cis-APiC) instead of cis-2-Aminocyclohexanecarboxylic acid (cis-ACHC) can enhance the aqueous solubility of mixed-helical peptides without affecting the helical folding.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gita Matuleviciute, Egle Arbaciauskiene, Neringa Kleiziene, Vilija Kederiene, Greta Ragaite, Migle Dagiliene, Aurimas Bieliauskas, Vaida Milisiunaite, Frank A. Slok, Algirdas Sackus
Summary: A series of novel heterocyclic amino acid compounds were developed and regioselectively synthesized as N-Boc protected esters, serving as achiral and chiral building blocks. The structures of these compounds were confirmed through H-1, C-13, and N-15-NMR spectroscopy and HRMS investigation.
Review
Immunology
Tian-Yi Zhang, Meng-Ting Cai, Yang Zheng, Qi-Lun Lai, Chun-Hong Shen, Song Qiao, Yin-Xi Zhang
Summary: Anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis is a rare subtype of autoimmune encephalitis, more commonly seen in middle-aged women with acute or subacute onset. It is characterized by symptoms such as memory loss, confusion, abnormal behavior, and seizures.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Yusuke Tokuhiro, Kosuke Yoshikawa, Sei Murayama, Takeshi Nanjo, Yoshiji Takemoto
Summary: This article presents an alternative practical method for the asymmetric synthesis of beta-amino-alpha-ketoacid equivalents, utilizing a highly stereoselective organocatalyzed Mannich-type addition using glyoxylate cyanohydrin. The optimal aminothiourea catalyst provides a variety of adducts with excellent yield and stereoselectivity, and the reaction can be applied to a wider range of imine precursors. Experimental and computational studies reveal the factors contributing to the high diastereoselectivity and enantioselectivity of the reaction.
Article
Spectroscopy
T. J. Sanders, J. L. Allen, R. Plathe, J. Horvat, R. A. Lewis
Summary: Well-defined absorption spectra of well-characterised alpha-glycine were obtained in the spectral range 2.5-7.5 THz, with four separate resonances observed at 93, 152, 188, and 223 cm(-1) at the lowest temperature. The observed frequency reduction with increasing temperature is attributed to phonon-mediated anharmonicity in the crystal potential.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Organic
Debasmita Mondal, Subhendu Pramanik, Chinmay Chowdhury
Summary: Palladium-catalyzed reactions provide an easy access to desired compounds, and the choice of suitable phosphine ligands is crucial for the success of the reaction.
Article
Chemistry, Organic
Zachary P. Sercel, Alexander W. Sun, Brian M. Stoltz
Summary: Enantioenriched gem-disubstituted 4-imidazolidinones were prepared in high yield and high enantioselectivity through Pd-catalyzed decarboxylative asymmetric allylic alkylation. A rapid synthetic route starting from 2-thiohydantoin was developed, and the orthogonality of the protecting groups used for nitrogen-rich products was demonstrated, indicating potential applications in drug design.
Review
Dentistry, Oral Surgery & Medicine
Zizheng Wang, Weicheng Chan, Yuan Yue
Summary: This article summarizes and analyzes the existence and regulation mechanism of the non-canonical inflammasome in periodontitis.
Article
Chemistry, Organic
Rajagopal Rajesh, Jai Anand Garg, Prabaharan Thiruvengetam, Rajesh Kunjanpillai
Summary: In this study, a simple and effective method for the addition of aromatic amines to activated olefins was discovered. The combination of NiBr2 and AgOTf catalysts resulted in high yields of the desired products, allowing for the addition of aromatic amines with various electron-donating and electron-withdrawing groups.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Medicine, General & Internal
Jing Yang, Jichen Du, Jing Zhao, Haichao Liu, Lvming Zhang, Lina Cai, Qi Wang, Bailin Han, Jiangbo Cui
Summary: Anti-AMPAR encephalitis, an autoimmune neurological disorder often associated with neoplasms, requires regular tumor screening for patients. Early diagnosis and prompt intervention are crucial for the rapid progression of the disease, otherwise it may lead to tragic outcomes.
Article
Chemistry, Medicinal
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo
Summary: In this study, the activity of TxID and its loop2-modified mutants were evaluated using an electrophysiological assay. The results showed a decrease in inhibition against r alpha 3 beta 4 and r f alpha 6/ alpha 3 beta 4 nAChRs for the 4/7-subfamily mutants [+9A]TxID, [+10A]TxID, [+14A]TxID, and all the 4/5-subfamily mutants, indicating that the insertion or truncation of the 9th, 10th, and 11th amino acid results in a loss of inhibition, and the truncation of loop2 has more pronounced impacts on its functions. These findings enhance the understanding of ff-conotoxin, provide guidance for further modifications, and offer a perspective for future studies on the molecular mechanism of the interaction between ff-conotoxins and nAChRs.
Article
Chemistry, Multidisciplinary
Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin
Summary: l-Threonine aldolase from Actinocorallia herbida (AhLTA) is an ideal catalyst for producing l-threo-4-methylsulfonylphenylserine, and engineering the enzyme through a combinatorial active-site saturation test (CAST) and sequence conservatism analysis has successfully improved the C-beta stereoselectivity. The mutant Y314R demonstrated higher diastereomeric excess (de) in asymmetric synthesis, showcasing the potential of directly controlling substrates in the active pocket for industrial applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Mathematics
Xiaoling Zhang, Xuesong Zhang, Mengke Wu
Summary: This paper investigates conformal transformations between two almost regular general (alpha,beta)-metrics. The necessary and sufficient conditions for conformal transformations preserving the mean Landsberg curvature are obtained by using the method of special coordinate system. Furthermore, a rigidity theorem for regular general (alpha,beta)-metrics is proved.
Article
Chemistry, Organic
Gautam P. P. Sadawarte, Nilesh K. K. Halikar, Amol D. D. Kale, Vasant B. B. Jagrut
Summary: A new synthetic methodology for the preparation of 5-Substituted-3-Phenyl-2-Thioxoimidazolidin-4-Ones has been reported. It involves the use of various amino acids, phenylisothiocyanate, and sodium oxalate in water, with the reaction monitored by TLC. Ten compounds were synthesized, characterized, and screened for amylase inhibition activity, showing moderate to good activity comparable to the standard drug molecule.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Biochemical Research Methods
Ming Chen, Min Zhang, Linhui Zhai, Hao Hu, Ping Liu, Minjia Tan
JOURNAL OF PROTEOME RESEARCH
(2017)
Article
Biochemical Research Methods
Min Zhang, Jun-Yu Xu, Hao Hu, Bang-Ce Ye, Minjia Tan
Article
Biochemistry & Molecular Biology
Jun-Yu Xu, Lei Zhao, XinXin Liu, Hao Hu, Ping Liu, Minjia Tan, Bang-Ce Ye
ACS CHEMICAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Zhimin Huang, Junxing Zhao, Wei Deng, Yingyi Chen, Jialin Shang, Kun Song, Lu Zhang, Chengxiang Wang, Shaoyong Lu, Xiuyan Yang, Bin He, Jinrong Min, Hao Hu, Minjia Tan, Jianrong Xu, Qiufen Zhang, Jie Zhong, Xiaoxiang Sun, Zhiyong Mao, Houwen Lin, Mingzhe Xiao, Y. Eugene Chin, Hualiang Jiang, Ying Xu, Guoqiang Chen, Jian Zhang
NATURE CHEMICAL BIOLOGY
(2018)
Article
Biology
Shi Chen, Rafal P. Wiewiora, Fanwang Meng, Nicolas Babault, Anqi Ma, Wenyu Yu, Kun Qian, Hao Hu, Hua Zou, Junyi Wang, Shijie Fan, Gil Blum, Fabio Pittella-Silva, Kyle A. Beauchamp, Wolfram Tempel, Hualiang Jiang, Kaixian Chen, Robert J. Skene, Yujun George Zheng, Peter J. Brown, Jian Jin, Cheng Luo, John D. Chodera, Minkui Luo
Article
Chemistry, Multidisciplinary
Wei Hu, Yi Yuan, Cai-Hu Wang, Hong-Tao Tian, An-Di Guo, Hui-Jun Nie, Hao Hu, Minjia Tan, Zhuo Tang, Xiao-Hua Chen
Article
Chemistry, Analytical
Hao Hu, Wensi Zhao, Mengdi Zhu, Lei Zhao, Linhui Zhai, Jun-yu Xu, Ping Liu, Minjia Tan
ANALYTICAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Shu Ye, Linhui Zhai, Hao Hu, Minjia Tan, Shichun Du
Summary: The BoxCar method was found to enhance protein identification depth and reproducibility in diabetic urinary proteome analysis, resulting in increased number of identified proteins and better quantitative reproducibility compared to the standard DDA method, especially in single or multiple diabetic urine samples.
PROTEOMICS CLINICAL APPLICATIONS
(2021)
Article
Biochemical Research Methods
Quan Liu, Bingbing Hao, Mingya Zhang, Zhiwei Liu, Yuqi Huang, Xiaoxiao Zhao, Hao Hu, Minjia Tan, Jun-Yu Xu
Summary: This study utilized mass spectrometry-based quantitative proteomic strategy to investigate the molecular differences in HDACi vorinostat (SAHA) sensitive and resistant cell lines. The results revealed potential new drug combinations and shed light on the molecular mechanisms of drug resistance and therapeutic efficacy in solid malignancies. Proteomic analysis indicated alterations in the transcription process and protein homeostasis may contribute to the synergistic utilization of drug combinations.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Cell Biology
Linhui Zhai, Le Wang, Hao Hu, Quan Liu, Sangkyu Lee, Minjia Tan, Yinan Zhang
Summary: High-throughput profiling of protein C-termini is challenging, but this study developed a strategy using 2-PCA and biotin labeling for efficient and high-throughput analysis of protein C-terminome.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
An-Di Guo, Ke-Nian Yan, Hao Hu, Linhui Zhai, Teng-Fei Hu, Haixia Su, Yijia Chi, Jinyin Zha, Yechun Xu, Dongxin Zhao, Xiaojie Lu, Yong-Jiang Xu, Jian Zhang, Minjia Tan, Xiao-Hua Chen
Summary: The study developed a light-induced lysine (K) enabled crosslinking (LIKE-XL) strategy for spatiotemporal and global profiling of DNA-protein interactions. By capturing weak and transient DNA-protein interactions, LIKE-XL can discover low-affinity transcription-factor/DNA interactions using specific DNA baits and identify previously unknown binding sites. Additionally, it can decipher the dynamics of the transcription factor subproteome in response to drug treatment and identify downstream target transcription factors, providing insight into their dynamic transcriptional networks. LIKE-XL offers a complementary method to expand the DNA-protein profiling toolbox and map accurate DNA-protein interactomes for better understanding of protein function in health and disease.
Article
Biochemistry & Molecular Biology
Ying Dong, Hao Hu, Xuan Zhang, Yunkai Zhang, Xin Sun, Hanlin Wang, Weijuan Kan, Min-jia Tan, Hong Shi, Yi Zang, Jia Li
Summary: AMPK inhibits lung cancer metastasis by relieving H3K9me2-mediated silencing of epithelial genes (e.g., CDH1) through activation by metformin. This process involves interaction between PHF2, a H3K9me2 demethylase, and AMPK alpha 2. AMPK phosphorylates PHF2 at S655 site, enhancing PHF2 demethylation activity and promoting the transcription of CDH1.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
An-Di Guo, Dan Wei, Hui-Jun Nie, Hao Hu, Chengyuan Peng, Shao-Tong Li, Ke-Nian Yan, Bin-Shan Zhou, Lei Feng, Chao Fang, Minjia Tan, Ruimin Huang, Xiao-Hua Chen
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kun Qian, Hao Hu, Hui Xu, Y. George Zheng
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2018)
Article
Hematology
Hairui Su, Chiao-Wang Sun, Szu-Mam Liu, Xin He, Hao Hu, Kevin M. Pawlik, Tim M. Townes, Xiaosi Han, Christopher A. Klug, Maged Henary, Yabing Chen, Ling Li, Y. George Zheng, Xinyang Zhao
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
