Article
Chemistry, Inorganic & Nuclear
Weibin Yu, Feng-Yi Qiu, Shi-Ting Luo, Hua-Tian Shi, Guozan Yuan, Xianwen Wei
Summary: Researchers have successfully constructed a triply interlocked [2]catenane with confirmed solid-state structure and solution properties, showing potential applications in drug delivery systems.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Ying-Ying Zhang, Feng-Yi Qiu, Hua-Tian Shi, Weibin Yu
Summary: By tuning the widths of organometallic dinuclear building blocks, two fascinating triply interlocked catenanes and one simple triangular prism metallacage were constructed. Interestingly, the interlocked architectures were disassembled in the presence of large aromatic molecules to form their corresponding monomeric host-guest complexes.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Organic
Milo D. Cornelissen, Simone Pilon, Jan H. van Maarseveen
Summary: Mechanically interlocked molecules, such as catenanes and rotaxanes, exhibit unique properties and have potential applications as artificial molecular machines and drug discovery targets. Covalent and non-covalent strategies each have their own advantages and limitations, but combining them may lead to new research opportunities.
SYNTHESIS-STUTTGART
(2021)
Review
Materials Science, Multidisciplinary
Yusuke Horita, Mai Ishimi, Yuichi Negishi
Summary: Metal nanoclusters (NCs), especially anion-templated Ag NCs, are of great interest in nanoscale materials research due to their size-specific physicochemical properties. The synthesis methods and influences of central anions on the geometric structure of anion-templated Ag NCs, including halide ions, chalcogenide ions, oxoanions, polyoxometalate, or hydride/deuteride, are summarized in this review. This summary serves as a reference for the current status of anion-templated Ag NCs, and may contribute to the development of novel geometric structures and physicochemical properties.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Magdalena M. Lozinska, Elliott L. Bruce, James Mattock, Ruxandra G. Chitac, Paul A. Cox, Alessandro Turrina, Paul A. Wright
Summary: High silica zeolite ZK-5 can be prepared by interzeolite conversion from ultrastable zeolite Y using alkali metal cations and nitrate anions as co-templating agents, without the need for organic structure directing agents. The mechanism, involving the ordering of zeolite framework, alkali metal cations, and nitrate anions, has been established through various analyses. Ammonium exchange followed by heating can further transform ZK-5 into microporous zeolite ZK-5.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Rui Ge, Xin-Xiong Li, Shou-Tian Zheng
Summary: The search for feasible strategies to construct high-nuclear silver clusters using anions as templates, such as polyoxometalates (POMs), has attracted continuous interest. POMs have been widely employed to direct the formation of silver clusters and stabilize the final products, showcasing promising applications in various fields.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jin-Ping Gao, Zhikai Qi, Fu-Qiang Zhang, Xian-Ming Zhang
Summary: A thiolate-protected silver nanocluster was synthesized using a polyoxometalate template method, providing a new approach for developing high-nuclearity metal nanoclusters with various structures.
Article
Chemistry, Multidisciplinary
Li Li, Yanjie Zhu, Baoliang Han, Qiongyi Wang, Luming Zheng, Lei Feng, Di Sun, Zhi Wang
Summary: In this study, a core-shell silver cluster composed of polyoxovanadates and a silver shell was synthesized, providing insights for the further construction of high-nuclearity silver clusters templated by polyoxovanadates. The solution behavior, solid-state stability, and photoelectric properties of the {V10O28@Ag-50} structure were discussed in detail.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Mandira Nandi, Somnath Bej, Tarun Jana, Pradyut Ghosh
Summary: Research on mechanically interlocked molecules has made significant progress in recent decades. The focus has been on the synthesis of functional MIMs for applications in various scientific fields. These interlocked molecules have unique structures, multi-functionalities, and potential applications in diverse areas.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Alejandro Lopez-Moreno, Julia Villalva, Emilio M. Perez
Summary: SWNTs are a highly interesting nanomaterial, where chemical modifications can enhance their intrinsic properties. The mechanical bond is appealing for materials science and SWNTs. Making MINTs has potential advantages compared to covalent or classic supramolecular derivatives.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Shu Niu, Hongyan Xiao, Xiao-Di Yang, Huan Cong
Summary: This study presents the preparation and properties of a novel polyfluorinated macrocycle, meta-WreathArene. The macrocycle can adopt a cone conformation in acetone solution and form dimer capsules through hydrogen bonds induced by chloride anions. Each dimer capsule consists of two meta-WreathArene and two chloride anions and has been characterized both in solution and in the solid state.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Przemyslaw Gawel, Steffen L. Woltering, Yaoyao Xiong, Kirsten E. Christensen, Harry L. Anderson
Summary: The study reported a new bulky masked alkyne equivalent (MAE) based on t-butylbicyclo[4.3.1]decatriene, which was used to synthesize a polyyne [2]rotaxane and a masked-polyyne [3]rotaxane. Photolysis experiments revealed that photochemical unmasking did not cleanly proceed to prepare extended encapsulated polyyne polyrotaxanes, highlighting the challenges involved in this approach to interlocked carbon-rich architectures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Alex Mapp, Jamie T. Wilmore, Paul D. Beer, Jose M. Goicoechea
Summary: Described the synthesis of a new class of inorganic rotaxanes containing gold(I) triazaphosphole stoppers using the cyaphide-azide 1,3-dipolar cycloaddition reaction. Bis-azides reacted with Au(IDipp)(CP) in aromatic solvents to produce interlocked molecules via an inorganic click reaction. The resulting organometallic rotaxanes were air- and moisture-stable and could be purified under aerobic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Andreas Erichsen, Gunther H. J. Peters, Sophie R. Beeren
Summary: Delta-CD, a minor component of a complex mixture of linear and cyclic glucans, can be synthesized in unprecedented yields by employing a unique template in an enzyme-mediated dynamic combinatorial library of cyclodextrins. NMR spectroscopy studies revealed that delta-CD can form pseudorotaxanes with up to three bolaamphiphiles. This research provides a new method for the preparative-scale synthesis of delta-CD.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Biao Wu, Xin-Xiong Li, Shou-Tian Zheng, Jianping Xie
Summary: The compound Ag-34, which contains a polyoxoniobate (PONb) template, was synthesized using the solvothermal method combined with volatilization. This is the first successful isolation of a silver cluster with PONb template. The luminescence, solution behavior, and solid-state stability of Ag-34 were extensively studied. Electrospray ionization mass spectrometry confirmed the integrity of Ag-34's skeleton in solution. Its unique luminescent behavior shows potential for temperature detection. This work is expected to inspire further research on PONb-templated high-nuclearity silver clusters.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Jonathan R. J. Yong, Eriks Kupce, Tim D. W. Claridge
Summary: NMR supersequences allow for faster experiments by tailoring the detection of NMR responses. The online tool GENESIS generates pulse programs for NOAH supersequences compatible with Bruker spectrometers. It provides customized supersequences, related scripts, and detailed instructions, while also facilitating the dissemination of new developments in NOAH sequences.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Connor W. Patrick, Joseph F. Woods, Przemyslaw Gawel, Claire E. Otteson, Amber L. Thompson, Tim D. W. Claridge, Ramesh Jasti, Harry L. Anderson
Summary: This study reports a new method for synthesizing stable carbyne insulated molecular wires through the synthesis of polyyne polyrotaxanes. Using an active metal template route with dicobalt carbonyl masked alkyne equivalents, two [3]rotaxanes were successfully synthesized and compared with naked polyyne dumbbell. The results showed that the nanohoop rotaxane exhibited 4.5 times greater thermal stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
James R. Larkin, Susan Anthony, Vanessa A. Johanssen, Tianrong Yeo, Megan Sealey, Abi G. Yates, Claire Friedemann Smith, Timothy D. W. Claridge, Brian D. Nicholson, Julie-Ann Moreland, Fergus Gleeson, Nicola R. Sibson, Daniel C. Anthony, Fay Probert
Summary: This study demonstrates that biomarkers within the blood metabolome analyzed by NMR metabolomics can aid in the early diagnosis of cancer and distinguish between patients with and without metastatic disease in a mixed population of patients referred from primary care.
CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jimmy Wang, Matthew A. Horwitz, Alexander B. Durr, Francesco Ibba, Gabriele Pupo, Yuan Gao, Paolo Ricci, Kirsten E. Christensen, Tejas P. Pathak, Timothy D. W. Claridge, Guy C. Lloyd-Jones, Robert S. Paton, Veronique Gouverneur
Summary: Asymmetric catalytic azidation using inexpensive sodium azide has been studied using hydrogen bonding phase-transfer catalysis (HB-PTC). The structure of novel hydrogen bonded azide complexes were analyzed computationally, in the solid state by X-ray diffraction, and in solution phase by NMR spectroscopy. This study demonstrates that HB-PTC can be used as an activation mode for inorganic salts other than metal alkali fluorides, showing potential for applications in asymmetric synthesis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinovic
Summary: The substitution of nitrogen with phosphorus substantially affects the interactions between N-epsilon-methyllysine binding proteins and demethylases.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ji-Yuan Du, Tudor Balan, Tim D. W. Claridge, Martin D. Smith
Summary: This study presents a highly enantioselective and ring-closing synthesis of medium ring lactams, utilizing an intramolecular counterion-directed C-alkylation reaction. The resulting product contains complex chiral elements and is formed through an enolate-driven configurational relaxation process to achieve alkylative ring closure.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Andrew Docker, Igor Marques, Heike Kuhn, Zongyao Zhang, Vitor Felix, Paul D. Beer
Summary: Chalcogen bonding (ChB) is a powerful noncovalent interaction based on sigma-hole that is rapidly gaining attention in supramolecular chemistry. Recent studies have shown that ChB donor strength and potency are highly sensitive to local electronic environments, including redox-switchable on/off anion binding and sensing capability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Michael C. Pfrunder, David L. Marshall, Berwyck L. J. Poad, Ethan G. Stovell, Benjamin Loomans, James P. Blinco, Stephen J. Blanksby, John C. McMurtrie, Kathleen M. Mullen
Summary: Coordination cages with well-defined cavities have great potential in catalysis due to the combination of molecular confinement effects and transition-metal redox chemistry. It has been found that these coordination cages can be reduced from their native 16(+) oxidation state to the 2(+) state in the gas phase without structural degradation. The reaction rate constants for each reduction step were determined, and the incorporation of a C-60-fullerene guest or alteration of the cage chemical structure had no noticeable effect on the reduction process. The reactivity of highly reduced cage species towards molecular oxygen can be switched-on after a threshold number of reduction steps, which is influenced by the guest molecules and the structure of cage components.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Henrik Gotfredsen, Jie-Ren Deng, Jeff M. Van Raden, Marcello Righetto, Janko Hergenhahn, Michael Clarke, Abigail Bellamy-Carter, Jack Hart, James O'Shea, Timothy D. W. Claridge, Fernanda Duarte, Alex Saywell, Laura M. Herz, Harry L. Anderson
Summary: Researchers have successfully bent linear photonic wires into ring structures using oligo-pyridyl templates, creating nanorings with 24 porphyrin units and a single butadiyne link. This system exhibits two distinct excited state energy transfer processes.
Article
Biochemistry & Molecular Biology
Vera Sousa, AderitoJ. R. Amaral, Edgar J. Castanheira, Igor Marques, Joao M. M. Rodrigues, Vitor Felix, Joao Borges, Joao F. Mano
Summary: This study reported the development of strong, homogeneous, transparent HA-functionalized G-quadruplex hydrogels with injectable, thermo-reversible, conductive, and self-healing properties. The supramolecular polymeric hydrogels were formed through hydrogen bonding and π-π stacking interactions between G, HA-PBA, and K+ ions. Microchannel-embedded 3D constructs exhibited enhanced cell viability compared to bulk hydrogels, indicating their potential in tissue regeneration, drug screening, or organ-on-a-chip applications.
Article
Chemistry, Physical
Paulo J. Costa, Frederico F. Martins, Chao Pi, Xiuling Cui, Maria Jose Calhorda
Summary: PdCl2 was found to catalyze the C-H activation of QOs through the formation of a metallacycle or an η(3)-QO complex. Activation at the C8 position resulted in a lower energy barrier compared to activation at the C2 position. The presence of water led to C8-H activation and the formation of 2-quinolinones.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Ona Sivickyte, Paulo J. Costa
Summary: Halogen bonds have various applications in catalysis, material design, anion recognition, and medicinal chemistry. Developing a simple, widely applicable, and computationally cheap descriptor is a challenge but can facilitate the discovery of new applications and improve existing ones.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sara Realista, Paulo J. Costa, Luisa B. Maia, Maria Jose Calhorda, Paulo N. Martinho
Summary: Cyclic voltammetry and bulk electrolysis experiments showed that [Ni(ii)(salphen)] [1], [Ni(ii)(Bu-t-salphen)] [2], and a binuclear Ni(ii) compound combining salphen and Bu-t-salphen [3] can react with CO2 to generate a stable metal-carbonyl species under anaerobic conditions. When exposed to air, a stoichiometric amount of CO is released and protonation regenerates the initial complex. Through various spectroscopy studies and DFT calculations, it is proposed that the reduction of [Ni(i)(salphen)](-), (2)[1](-), leads to the formation of a CO2 complex, (2)[1(CO2)](-), which is further reduced to (3)[1(CO2)](2-). After protonation, the coordinated CO2 is reduced to CO and released, regenerating (1)[1]. The release of CO competes with CO2 in the second cycle, deactivating the system.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Jonathan R. J. Yong, Eriks Kupce, Tim D. W. Claridge
Summary: NOAH supersequences is a method that combines multiple 2D NMR experiments into one measurement. However, it has been limited to experiments with comparable sensitivity. This study proposes a scheme that overcomes this limitation by combining experiments with very different sensitivities, such as 1,1-ADEQUATE, N-15 HMBC, and C-13 HSQC.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Andreia Fortuna, Paulo J. Costa
Summary: This study assessed the impact of three off-center point-charge (EP) models on the prediction of hydration free energies. The results showed that using certain EP models led to a slight improvement in the prediction of hydration free energies, especially for chlorinated compounds. However, this improvement was not related to the formation of halogen bonds but rather to the improvement in hydrogen bond sampling. The choice of EP model was particularly important for iodinated molecules, with compounds possessing a larger sigma-hole showing some improvement in prediction, while weaker XB donors showed significantly worse results.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
