Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines

An enantio-and diastereoselective direct vinylogous Mannich reaction of alpha, alpha-dicyanoolefins and N-sulfonyl alkylimines has been developed by the catalysis of a new family of bifunctional organocatalysts merging chiral BINOL and 9-amino-9-deoxyepicinchona alkaloid skeletons, from which chiral beta-, delta- or gamma-amino compounds could be efficiently derived.