4.7 Article

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

期刊

CHEMICAL COMMUNICATIONS
卷 -, 期 40, 页码 4962-4964

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ROYAL SOC CHEMISTRY
DOI: 10.1039/b812901k

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资金

  1. EPSRC
  2. AstraZeneca
  3. Pfizer
  4. EPSRC [EP/C01135X/1, EP/D074487/1] Funding Source: UKRI
  5. Biotechnology and Biological Sciences Research Council [BB/C500252/1] Funding Source: researchfish
  6. Engineering and Physical Sciences Research Council [EP/C01135X/1, EP/D074487/1] Funding Source: researchfish

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The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.

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