Article
Chemistry, Organic
Alessandra Casnati, Dawid Lichosyt, Bruno Lainer, Lukas Veth, Pawel Dydio
Summary: The research presents a multicatalytic method for converting alkenes, unsaturated aliphatic alcohols, and aryl boronic acids into secondary benzylic alcohols with high stereoselectivity. Prochiral allylic alcohols can also be selectively transformed into different stereoisomers of the product.
Article
Chemistry, Organic
Zhi-Cheng Yu, You Zhou, Xiang-Long Chen, Jin-Tian Ma, Li-Sheng Wang, Yan-Dong Wu, An-Xin Wu
Summary: A reductive coupling reaction was established for the synthesis of diaryl 1,2-dicarbonyl compounds from aryl methyl ketones. The reaction involves C(CO)-C(sp3) bond cleavage and proceeds through an electron transfer process. Notably, this reaction is simple to operate, has mild reaction conditions, and is applicable to a wide range of substrates.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Guohui Zhang, Qianqian Liang, Wei Yang, Shaohua Jiang, Zhiping Wang, Chunyan Zhang, Guoying Zhang
Summary: Reductive homocoupling transformations mediated by bases and TMSCN have been utilized for the synthesis of 1,2-disubstituted ethanones. This protocol offers a method for the synthesis of functionalized ethanones from aldehydes without the need for transition metals, all in a single reaction vessel.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Applied
Fan Yang, Yuta Saiki, Koichi Nakaoka, Tadashi Ema
Summary: This study reported the solvent-free N-formylation reaction catalyzed by Cu(OAc)(2), which used CO2 and phenylsilane to react with 2-(methylamino)pyridine and produced N-methyl-N-(2-pyridyl)formamide. The improved solubility of copper ion and enhanced nucleophilicity of acetate ion played positive roles in the activation of phenylsilane.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Hao Liu, Meng-Ling Lin, Yin-Jun Chen, Yin-Hui Huang, Lin Dong
Summary: A Rh(iii)-catalyzed three-component C-H bond functionalization protocol has been successfully used to synthesize complex polycyclic BINOL derivatives, with the in situ formation of intermediate amides from aldehydes and amines. This high efficiency strategy allows for rapid and selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Md Shafaat Al Mehedi, Dare E. George, Jetze J. Tepe
Summary: This article reports the synthesis of 3,4-disubstituted 1H-pyrazoles and 3,5-disubstituted pyridines by reacting epoxides with hydrazine and ammonia, respectively. Both reactions employ Sc(OTf)3 as a Lewis acid and utilize different reaction conditions for subsequent transformations.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Davide Ceradini, Kirill Shubin
Summary: For the first time, yttrium triflate was utilized as a green catalyst in the synthesis of alpha-aminophosphonates through a one-pot three-component Birum-Oleksyszyn reaction, enhancing the yield and reaction chemoselectivity by achieving a proper balance in the complex network of reactions.
Article
Chemistry, Organic
Shiv Chand, Anup Kumar Sharma, Anand Kumar Pandey, Krishna Nand Singh
Summary: An efficient visible-light-induced synthesis of trans-oxiranes has been achieved via decarboxylative stereospecific epoxidation of trans-cinnamic acids using aryldiazonium salts. The reaction is facile, straightforward, and exhibits good functional group tolerance and substrate scope.
Article
Chemistry, Organic
Bumpei Maeda, Yusuke Aihara, Ayato Sato, Toshinori Kinoshita, Kei Murakami
Summary: This article describes a photoinduced benzylic C-H thiocyanation method. A series of alkyl thiocyanates were efficiently synthesized using Selectfluor as the oxidant, and one-pot isothiocyanation was achieved following the C-H thiocyanation. The resulting thiocyanates and isothiocyanates can be applied to the divergent transformation of pharmaceuticals.
Article
Chemistry, Organic
Kai N. Sands, Benjamin S. Gelfand, Thomas G. Back
Summary: Aryl selenonic acids were synthesized from aryl bromides via a one-pot method, with yields ranging from 77-90%. The synthesis involved metalation, selenation, oxidation with hydrogen peroxide, and ion exchange. One derivative readily dehydrated to form a cyclic selenonic ester, while two minor byproducts were identified as mixed salts of aryl selenonic acids with either aryl seleninic or selenious acid through X-ray crystallography.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tien Tan Bui, Hee-Kwon Kim
Summary: A practical one-pot synthesis of ketones from primary alcohols was successfully performed using dibromoisocyanuric acid and various aromatic compounds in the presence of Fe2O3. This method provides an efficient and useful approach to synthesize aromatic ketones from primary alcohols under mild reaction conditions, yielding high amounts of products.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Mingxin Liu, Zewen Wu, Xianghua Kong, Xu Zhang, Lida Tan, Hong Guo, Chao-Jun Li
Summary: The generation of BTX compounds from non-petroleum feedstocks is important for chemists in terms of sustainability. A novel synthesis of toluene catalyzed by GaN semiconductor nanowire arrays is reported, which can facilitate the generation of toluene from methane and methanol under both photo-irradiation and thermal conditions. Detailed computational studies revealed different mechanisms for photo- and thermal toluene synthesis.
Article
Chemistry, Physical
Mingxin Liu, Zewen Wu, Xianghua Kong, Xu Zhang, Lida Tan, Hong Guo, Chao-Jun Li
Summary: A novel synthesis of toluene using GaN semiconductor nanowire arrays as catalyst is reported. The GaN nanowire arrays can synergistically facilitate the facile generation of toluene from methane and methanol under photo-irradiation or thermal conditions. Detailed computational studies revealed different mechanisms involved in the photo- and thermal-toluene synthesis.
Article
Chemistry, Applied
Feng Ma, Xian-Tao Wu, Le-Wei Miao, Fuxing Sun, Yi-Jun Jiang, Peng Chen
Summary: A general, efficient, and regioselective protocol for the synthesis of trifluoromethylated bis(carbazolyl)methanes has been developed. This metal-free transformation proceeds smoothly under air atmosphere and has a broad scope for both reaction partners. This method can also be extended to the synthesis of difluoromethylated and chlorodifluoromethylated bis(carbazolyl)methanes.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Shoko Nagahata, Seiya Takei, Satoshi Ueno
Summary: In this study, gamma-phenyl-beta,gamma-unsaturated ketones were synthesized in situ and reacted with alpha,beta-unsaturated carbonyls to form tri- or diarylated benzophenones in a one-pot manner.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)