Review
Pharmacology & Pharmacy
Meifang Zheng, Runping Gao
Summary: This article reviews the mechanisms and potential therapeutic effects of vitamin D and its analogues in the treatment of pancreatic fibrosis, as well as the relationship between vitamin D deficiency and the risk of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Na Wang, Tianchun Zhou, Xiaoxia Ma, Yuping Lin, Yan Ding
Summary: This study evaluated the association between maternal B vitamins in early pregnancy and gestational diabetes mellitus (GDM) risk. The results showed that higher maternal serum vitamin B-1 and B-6 levels in early pregnancy were associated with increased GDM risk, while sufficient vitamin B-12 status was associated with lower GDM risk.
Article
Biochemistry & Molecular Biology
Ananyaa Agrawal, Pratibha Chanana, Vikas Yadav, Vilakshan Bhutani, Naidu Subbarao, Aradhana Srivastava
Summary: The objective of this study was to identify potential inhibitors of Influenza surface HA. FMNNa and FMNCa were found to exhibit potential as HA inhibitors through in silico studies and MD simulations.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Nutrition & Dietetics
Erendira Patricia Perez-Munoz, Marilena Antunes-Ricardo, Mariana Martinez-Avila, Daniel Guajardo-Flores
Summary: Medicinal plants, such as Eryngium spp., contain natural compounds that can be used to treat metabolic syndrome and diabetes by regulating blood lipids, glucose, and oxidative stress.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Daniel Favre, Jackson F. Harmon, Ali Zhang, Matthew S. Miller, Igor A. Kaltashov
Summary: Polyoxidometalates (POMs) have diverse biological properties and can be utilized for therapeutic applications. This study focuses on decavanadate (V10) as a potential antiviral agent and highlights its interaction with the SARS-CoV-2 spike protein and its impact on virus entry into host cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Verdiana Marchiano, Maria Matos, Esther Serrano, Jose R. Alvarez, Ismael Marcet, M. Carmen Blanco-Lopez, Gemma Gutierrez
Summary: Nanomaterials have shown significant advantages in the production of pharmaceuticals, cosmetics, food, and food packaging. This study focuses on encapsulating vitamin B-12 in nanovesicles and explores the effects of different formulations and processing steps on vesicle characteristics.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Stefan Bidula
Summary: G4s are non-canonical secondary structures in DNA and RNA that play roles in transcription and translation regulation. They are being studied as potential drug targets in cancer due to their ability to regulate gene expression and inhibit cancer cell growth. A computational analysis revealed high frequencies of G4-forming sequences in the promoters of various cytokines and chemokines, similar to those observed in proto-oncogenes. Additionally, many gene promoters contain sequences with high propensity to form G4s, mainly located in binding sites for transcription factors involved in inflammation and immunity.
Article
Chemistry, Multidisciplinary
Wang Hee Lee, Jun Gi Rho, Yeyoung Yang, Seulbi Lee, Sohui Kweon, Hyung-Mo Kim, Juhwan Yoon, Hongseo Choi, Eunyoung Lee, Su Ha Kim, Sohee You, Yujin Song, Young Soo Oh, Hwan Kim, Hwa Seung Han, Ji Hye Han, Myeongwoo Jung, Young Hwan Park, Yang Seon Choi, Sukyoung Han, Junho Lee, Sangdun Choi, Jung-Woong Kim, Jae Hyung Park, Eun Kyung Lee, Woo Keun Song, Eunha Kim, Wook Kim
Summary: Hyaluronic acid nanoparticles (HA-NPs) have been identified as a potential topical nanomedicine for effectively and safely treating psoriasis by suppressing immune responses and restoring skin barrier function without causing overt toxicity.
Review
Medicine, Research & Experimental
Urshila Naithani, Priyanjal Jain, Aastha Sachan, Prachi Khare, Reema Gabrani
Summary: This paper discusses the challenges in the clinical classification of systemic lupus erythematosus (SLE) due to its multifactorial nature and complex pathogenesis. It also highlights the importance of microRNAs (miRNAs) in the development and treatment of SLE, suggesting their potential as therapeutic targets.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Cristina Adriana Dehelean, Dorina Coricovac, Iulia Pinzaru, Iasmina Marcovici, Ioana Gabriela Macasoi, Alexandra Semenescu, Geza Lazar, Simona Cinta Pinzaru, Isidora Radulov, Ersilia Alexa, Octavian Cretu
Summary: This study synthesized and characterized two bioconjugates of rutin, rutin oleate (RUT-O) and rutin linoleate (RUT-L), through enzymatic esterification. The toxicological assessment showed that RUT-L exhibited favorable toxicological properties, while high concentrations of RUT-O resulted in cytotoxic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Kieran Allowitz, John J. Yoo, Justin R. Taylor, Omar A. Baloch, Kyra Harames, Kota Ramana
Summary: Benfotiamine, a lipid-soluble derivative of thiamine, has potent antioxidative and anti-inflammatory properties, and can be used to prevent various pathological complications including diabetic complications, inflammatory complications, and symptoms associated with infectious diseases.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Matthew Giese, Paul D. Davis, Robert H. Woodman, Greg Hermanson, Alex Pokora, Melissa Vermillion
Summary: Protease-activated prodrugs selectively activate cytotoxins in tumors while minimizing toxicity to normal tissues by leveraging increased protease activity in the tumor microenvironment and tight regulation in healthy tissues. Modulating cathepsin-mediated release of cytotoxic payload through steric shielding provided by appropriately designed hydrophilic linkers and conjugated carriers offers a potential strategy for balancing off-target and tumor-targeted payload release. Structural variables of linker architectures can be manipulated to effectively shield enzymatically labile trigger-payloads from enzymes with readily accessible binding sites.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Nutrition & Dietetics
He Helen Huang, Alan A. Cohen, Pierrette Gaudreau, Christiane Auray-Blais, David Allard, Michel Boutin, Isabelle Reid, Valerie Turcot, Nancy Presse
Summary: The study found a higher risk of vitamin B-12 deficiency among older adults. Dietary intake of vitamin B-12, especially from dairy sources, was associated with a decreased risk of low vitamin B-12 status and deficiency in older adults. Different food groups may have different contributions to reducing the risk of deficiency in older populations.
JOURNAL OF NUTRITION
(2022)
Article
Medicine, General & Internal
Lingling Liu, Kehang Xie, Mengmeng Yin, Xiaoqiu Chen, Binhuan Chen, Jianting Ke, Cheng Wang
Summary: This study found that serum potassium, albumin, and vitamin B-12 levels were lower in patients with fungal peritonitis compared to bacterial peritonitis patients. Additionally, lower levels of potassium and B-12 were independently associated with higher rates of technique failure in peritonitis cases. These findings suggest that serum potassium, albumin, and B-12 may serve as potential oxidative stress markers for fungal peritonitis.
ANNALS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani
Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Rakesh K. Harishchandra, Brittany M. Neumann, Arne Gericke, Alonzo H. Ross
Article
Biochemistry & Molecular Biology
Frank Heinrich, Srinivas Chakravarthy, Hirsh Nanda, Antonella Papa, Pier Paolo Pandolfi, Alonzo H. Ross, Rakesh K. Harishchandra, Arne Gericke, Mathias Loesche
Article
Nanoscience & Nanotechnology
Joana S. L. Oliveira, Gerald Brezesinski, Alexandra Hill, Arne Gericke
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2016)
News Item
Biophysics
Arne Gericke
BIOPHYSICAL JOURNAL
(2018)
Article
Biophysics
Zachary T. Graber, Joseph Thomas, Emily Johnson, Arne Gericke, Edgar E. Kooijman
BIOPHYSICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Brittany M. Neumann, Devin Kenney, Qi Wen, Arne Gericke
CHEMISTRY AND PHYSICS OF LIPIDS
(2018)
Article
Chemistry, Physical
Kyungreem Han, Richard M. Venable, Anne-Marie Bryant, Christopher J. Legacy, Rong Shen, Hui Li, Benoit Roux, Arne Gericke, Richard W. Pastor
JOURNAL OF PHYSICAL CHEMISTRY B
(2018)
Article
Biochemistry & Molecular Biology
Zachary T. Graber, Arne Gericke, Edgar E. Kooijman
CHEMISTRY AND PHYSICS OF LIPIDS
(2014)
Editorial Material
Biochemistry & Molecular Biology
Edgar E. Kooijman, Arne Gericke
CHEMISTRY AND PHYSICS OF LIPIDS
(2014)
Article
Cell Biology
Eduardo Villarreal-Ramirez, Ramon Garduno-Juarez, Arne Gericke, Adele Boskey
CONNECTIVE TISSUE RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Rafael Pulido, Suzanne J. Baker, Joao T. Barata, Arkaitz Carracedo, Victor J. Cid, Ian D. Chin-Sang, Vrushank Dave, Jeroen den Hertog, Peter Devreotes, Britta J. Eickholt, Charis Eng, Frank B. Furnari, Maria-Magdalena Georgescu, Arne Gericke, Benjamin Hopkins, Xeujun Jiang, Seung-Rock Lee, Mathias Loesche, Prerna Malaney, Xavier Matias-Guiu, Maria Molina, Pier Paolo Pandolfi, Ramon Parsons, Paolo Pinton, Carmen Rivas, Rafael M. Rocha, Manuel S. Rodriguez, Alonzo H. Ross, Manuel Serrano, Vuk Stambolic, Bangyan Stiles, Akira Suzuki, Seong-Seng Tan, Nicholas K. Tonks, Lloyd C. Trotman, Nicolas Wolff, Rudiger Woscholski, Hong Wu, Nicholas R. Leslie
Article
Chemistry, Physical
Kyungreem Han, Arne Gericke, Richard W. Pastor
JOURNAL OF PHYSICAL CHEMISTRY B
(2020)
Article
Biophysics
V. Siddartha Yerramilli, Alonzo H. Ross, Suzanne Scarlata, Arne Gericke
Summary: IQGAP1 is a scaffold protein that coordinates multiple signaling pathways, and its spatial and temporal resolution remains unclear. Through fluorescence imaging and correlation methods, the study reveals the interaction of IQGAP1 and PIPKI gamma on both the plasma membrane and in cytosol. Epidermal growth factor (EGF) stimulation drives the movement of cytosolic IQGAP1 towards the plasma membrane, promoting cytoskeletal changes. The study also uncovers the association of cytosolic IQGAP1-PIPKI gamma complexes with early endosomes and their aggregation upon EGF stimulation. The findings highlight the role of IQGAP1 in regulating cell migration through linking phosphoinositide lipid signaling with cytoskeletal reorganization.
BIOPHYSICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Erin E. Hickey, Austin Shigemoto, Arne Gericke, Shawn C. Burdette
Summary: This study presents two Zn2+ photocages and one photocage based on Sanger's reagent, and their binding affinities were measured using isothermal titration calorimetry (ITC). The results demonstrate that ITC is an effective measurement tool and consistent with UV-vis titration data.
ANALYSIS & SENSING
(2023)
Article
Endocrinology & Metabolism
Eduardo Villarreal-Ramirez, David Eliezer, Ramon Garduno-Juarez, Arne Gericke, Jose Manuel Perez-Aguilar, Adele Boskey
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
