期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 85, 期 5, 页码 638-644出版社
WILEY-BLACKWELL
DOI: 10.1111/cbdd.12448
关键词
aloe emodin; aloe emodin derivatives; antitumor activity; NCI-H460 cells; Hep G2 cells; structure activity relationship
资金
- World Class Institute (WCI) Program [WCI 2009-002]
- Global R&D Center (GRDC) Program - Ministry of ICT, Science and Future Planning (MISP)
- KRIBB Research Initiative Program
In this study, we have synthesized novel water soluble derivatives of natural compound aloe emodin 4(a-j) by coupling with various amino acid esters and substituted aromatic amines, in an attempt to improve the anticancer activity and to explore the structure-activity relationships. The structures of the compounds were determined by H-1 NMR and mass spectroscopy. Cell growth inhibition assays revealed that the aloe emodin derivatives 4d, 4f, and 4i effectively decreased the growth of HepG2 (human liver cancer cells) and NCI-H460 (human lung cancer cells) and some of the derivatives exhibited comparable antitumor activity against HeLa (Human epithelial carcinoma cells) and PC3 (prostate cancer cells) cell lines compared to that of the parent aloe emodin at low micromolar concentrations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据