In silicoTarget Fishing for the Potential Targets and Molecular Mechanisms of Baicalein as an Antiparkinsonian Agent: Discovery of the Protective Effects on NMDA Receptor-Mediated Neurotoxicity

Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism

(2012) Xin Yu et al.   LIFE SCIENCES

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

(2011) Li Zhang et al.   AAPS Journal

3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase

(2011) Li Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based systems biology for analyzing off-target binding

(2011) Lei Xie et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria

(2011) Xiao-xiu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

BindingDB and ChEMBL: online compound databases for drug discovery

(2011) Anne Mai Wassermann et al.   Expert Opinion on Drug Discovery

ReverseScreen3D: A Structure-Based Ligand Matching Method To Identify Protein Targets

(2011) Sarah L. Kinnings et al.   Journal of Chemical Information and Modeling

From in silico target prediction to multi-target drug design: Current databases, methods and applications

(2011) Alexios Koutsoukas et al.   Journal of Proteomics

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

(2011) Xin Mu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

(2010) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B

(2010) Daniele Bonivento et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Approaches to Target Fishing and Ligand Profiling

(2010) Didier Rognan   Molecular Informatics

GPCRDB: information system for G protein-coupled receptors

(2010) B. Vroling et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Novel Method for Generating Structure-Based Pharmacophores Using Energetic Analysis

(2009) Noeris K. Salam et al.   Journal of Chemical Information and Modeling

Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation

(2009) Kathryn Loving et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-d-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors

(2009) Kate E. Gilling et al.   NEUROPHARMACOLOGY

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease

(2009) M. Flint Beal   PARKINSONISM & RELATED DISORDERS

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

(2009) Xin Mu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

β-Synuclein Assembly as a Therapeutic Target of Parkinsons Disease and Related Disorders

(2008) Kenjiro Ono et al.   CURRENT PHARMACEUTICAL DESIGN

The increasing role of monoamine oxidase type B inhibitors in Parkinson's disease therapy

(2008) Lawrence W Elmer et al.   EXPERT OPINION ON PHARMACOTHERAPY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of Human 108V and 108M Catechol O-Methyltransferase

(2008) K. Rutherford et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile

(2008) Yinxia Cheng et al.   NEUROSCIENCE LETTERS

Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells

(2008) V. Badireenath Konkimalla et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro

(2007) M T Corasaniti et al.   BRITISH JOURNAL OF PHARMACOLOGY