☆ 4.4 Article

Synthesis, Antibacterial Activities, and 3D-QSAR of Sulfone Derivatives Containing 1, 3, 4-Oxadiazole Moiety

CHEMICAL BIOLOGY & DRUG DESIGN (2013)

期刊

CHEMICAL BIOLOGY & DRUG DESIGN

卷 82, 期 5, 页码 546-556

出版社

WILEY

DOI: 10.1111/cbdd.12181

关键词

3D-QSAR; antibacterial activities; CoMFA; CoMSIA; sulfone derivatives; synthesis

类别

Biochemistry & Molecular Biology Chemistry, Medicinal

资金

National Key Program for Basic Research [2010CB 126105]
Key Technologies RD Program [2011BAE06 B05-6]

向作者/读者索取更多资源

Protocol

Reagent

摘要

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R.solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R.solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29g/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R.solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80g/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70g/mL, respectively. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Biochemistry & Molecular Biology

3D-QSAR modeling and molecular docking studies on a series of 2, 4, 5-trisubstituted imidazole derivatives as CK2 inhibitors

Amina Goudzal, Abdellah El Aissouq, Hicham El Hamdani, El Ghalia Hadaji, Abdelkrim Ouammou, Mohammed Bouachrine

Summary: In this study, a 3D-QSAR analysis was performed on a series of 2, 4, 5-trisubstituted imidazole derivatives to design potent kinase II alpha subunit (CK2) inhibitors. The COMFA and COMSIA models showed excellent performance with high Q(2) and R-2 values. The validity of the models was confirmed through various validation tests. The study's findings provide useful theoretical references for future experimental studies.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

Agata Zieba, Tuomo Laitinen, Jayendra Z. Patel, Antti Poso, Agnieszka A. Kaczor

Summary: The study successfully constructed 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors with 1,3,4-oxadiazol-2-one moiety, which showed good statistical parameters and were validated using various techniques. The field contributions in the CoMFA and CoMSIA models varied, influencing the ligand-enzyme interactions in different ways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multi-combined 3D-QSAR, docking molecular and ADMET prediction of 5-azaindazole derivatives as LRRK2 tyrosine kinase inhibitors

Saida Khamouli, Salah Belaidi, Mebarka Ouassaf, Touhami Lanez, Said Belaaouad, Samir Chtita

Summary: The study performed a three-dimensional quantitative structure-activity relationships (3D-QSAR) analysis on 26 azaindazole derivatives as LRRK2 inhibitors, achieving high activity-descriptor relationship efficiency. The models were validated externally and through docking studies, confirming their reliability and providing valuable clues for designing new compounds against LRRK2. Furthermore, an analysis of the compounds' ADMET properties and drug likeness was conducted, aiding in the optimization of new anti-Parkinson drugs.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

添加到收藏夹

Article Chemistry, Physical

Combination of 2D and 3D-QSAR studies on DAPY and DANA derivatives as potent HIV-1 NNRTIs

Xiao Ding, Dongwei Kang, Lin Sun, Peng Zhan, Xinyong Liu

Summary: With the increasing number of AIDS patients, the search for new potent anti-HIV drugs becomes urgent. Through the analysis of CoMFA, CoMSIA, and 2D-QSAR models, insights into the design of novel anti-HIV agents can be obtained.

JOURNAL OF MOLECULAR STRUCTURE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure-Activity Relationship Studies Based on 3D-QSAR CoMFA/CoMSIA for Thieno-Pyrimidine Derivatives as Triple Negative Breast Cancer Inhibitors

Jin-Hee Kim, Jin-Hyun Jeong

Summary: In this study, a series of thieno-pyrimidine derivatives were analyzed using three-dimensional quantitative structure-activity relationship (3D-QSAR) to identify key structural features for inhibitory biological activities. Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) models were established, showing reliable and robust performance. The predictive capabilities of these models were confirmed through external validation and progressive scrambling stability test. This research provides valuable information for the further optimization and design of novel inhibitors against metastatic breast cancer.

MOLECULES (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

3D quantitative structure-activity relationships study on anti-gastric cancer of chrysin derivatives

Yunmei Liu, Zejie Tian, Hui Li, Zhenhua Liu, Lei Shi, Lingyan Yang

Summary: In this study, 3D-QSAR models were constructed to investigate the structure-activity relationship of chrysin. The structures of 54 chrysin derivatives were constructed using SYBYL-X 2.0 software, and the models were built using CoMFA and CoMSIA methods. The results showed that certain groups attached to the 7-O-alkane chain of chrysin, such as amino acids, enhance its activity, while excessively long chains or bulky hydrophobic groups reduce the activity. On the other hand, the introduction of bulky hydrophobic groups on the side chains of amino acids increases the activity of the molecule.

JOURNAL OF MATHEMATICAL CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

3D-QSAR-based design, synthesis and biological evaluation of 2,4-disubstituted quinoline derivatives as antimalarial agents

V. K. Vyas, S. Bhati, M. Sharma, P. Gehlot, N. Patel, S. Dalai

Summary: 2,4-Disubstituted quinoline derivatives were designed, synthesized, and evaluated for antimalarial activity based on a 3D-QSAR study. CoMFA and CoMSIA models were used on a dataset of 178 quinoline derivatives, and PLS analysis validated the results. 10 derivatives were synthesized and screened, with compounds #5 and #19 showing maximum reductions of 64% and 57% in parasitaemia level, respectively.

SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Insights into the structural requirements of triazole derivatives as promising DPP IV inhibitors: computational investigations

Bhumi M. Shah, Sneha R. Sagar, Priti Trivedi

Summary: Researchers have identified DPP IV as a target for diabetes treatment, and 3D QSAR studies have helped to determine important structural features of triazole derivatives, leading to the design of novel compounds that may serve as promising DPP IV inhibitors for the treatment of diabetes.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

3D-QSAR, Molecular Docking, and MD Simulations of Anthraquinone Derivatives as PGAM1 Inhibitors

Yuwei Wang, Yifan Guo, Shaojia Qiang, Ruyi Jin, Zhi Li, Yuping Tang, Elaine Lai Han Leung, Hui Guo, Xiaojun Yao

Summary: In this study, the structure-activity relationships and binding modes of a series of anthraquinone derivatives targeting PGAM1 were investigated using 3D-QSAR, molecular docking, and molecular dynamics simulations, which showed satisfactory predictive ability. Molecular dynamics simulations revealed key residues and dominant interactions, as well as stable hydrogen bond formations during the ligand binding process. Overall, the study provided theoretical guidance for the design of new anthraquinone derivatives as PGAM1 inhibitors.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approach

Swapnil P. Bhujbal, Jung-Mi Hah

Summary: Radiotherapy and chemotherapy are standard cancer treatments used in combination with surgery for around 60% of cancer patients. Only a few patients respond to immune checkpoint blockage due to low tumor immunogenicity, with tumor cells often evading immune surveillance through CD73 signaling and extracellular adenosine production. In this study, non-nucleotide small molecule inhibitors targeting CD73 were designed using molecular docking and 3D-QSAR studies, showing promising activity compared to existing compounds. Further experimental validation of these new inhibitors is required.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Medicinal

Anti-chronic myeloid leukemia activity and quantitative structure-activity relationship of novel thiazole aminobenzamide derivatives

Yuan Zhang, Juan Liu, Xin Wu, Suming Yang, Yao Li, Songbin Liu, Saifei Zhu, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Honglin Huang, Junmei Peng

Summary: The anti-chronic myeloid leukemia activity of thiazole aminobenzamide derivatives was tested in vitro using a viability assay method and was found to exhibit good inhibitory activities. Analysis using CoMFA and CoMSIA showed a relationship between the structure of these derivatives and their inhibition of leukemia cell activity, with specific substitutions improving the anti-CML activity.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Toxicology

3D-QSAR analysis of the interactions of flavonoids with human organic cation transporter 2

Yajuan Bi, Xue Wang, Huixiang Li, Yiqing Tian, Lifeng Han, Chunshan Gui, Youcai Zhang

Summary: Flavonoids, widely found in vegetables, fruits, grains, and herbs, exhibit inhibitory effects on the organic cation transporter 2 (OCT2) which plays a crucial role in drug-drug interactions. This study investigated the inhibitory effect of 28 flavonoids on OCT2 and revealed the structural features that affect their interaction. The findings provide valuable insights into the interactions and prediction of flavonoids with OCT2.

TOXICOLOGY LETTERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

In silico research on new sulfonamide derivatives as BRD4 inhibitors targeting acute myeloid leukemia using various computational techniques including 3D-QSAR, HQSAR, molecular docking, ADME/Tox, and molecular dynamics

Etibaria Belghalia, Mohamed Ouabane, Salma El Bahi, Hafiz Muzzammel Rehman, Abdelouahid Sbai, Tahar Lakhlifi, Mohammed Bouachrine

Summary: Acute myeloid leukemia, a serious condition affecting stem cells, can be treated using BRD4 inhibitors that suppress cell proliferation. Through molecular modeling techniques and simulation, this study revealed the structural elements and interaction mode of effective BRD4 inhibitors. The incorporation of bulky substituents on the pyridinone ring and hydrophobic/electrostatic substituents on the methoxy-substituted phenyl ring enhanced interactions with the BRD4 target, leading to improved oral bioavailability and non-toxic properties.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

添加到收藏夹

Article Chemistry, Medicinal

QSAR Studies, Synthesis, and Biological Evaluation of New Pyrimido-Isoquinolin-Quinone Derivatives against Methicillin-Resistant Staphylococcus aureus

Juan Andrades-Lagos, Javier Campanini-Salinas, Gianfranco Sabadini, Victor Andrade, Jaime Mella, David Vasquez-Velasquez

Summary: Antimicrobial resistance is a significant threat to global health according to the WHO. Our research group has developed a new family of antibacterial compounds that show activity against multidrug-resistant Staphylococcus aureus. The study explains the antibacterial activity of these compounds based on their molecular properties.

PHARMACEUTICALS (2023)

添加到收藏夹

Article Food Science & Technology

Structural Insights on Hyp-Gly-Containing Peptides as Antiplatelet Compounds through Topomer CoMFA and CoMSIA Analysis

Yijie Yang, Qi Tian, Shiming Li, Bo Li

Summary: In this study, 3D-QSAR analysis was performed to investigate the structure-activity relationship of collagen hydrolysate peptides. The results showed that Hyp, rather than Pro, had a greater impact on improving antiplatelet activity. The predicted peptide EOGE exhibited antiplatelet activity and inhibited thrombus formation.

FOODS (2023)

添加到收藏夹

Review Engineering, Environmental

Metal-organic framework-based materials: emerging high-efficiency catalysts for the heterogeneous photocatalytic degradation of pollutants in water

Caiyan Yue, Long Chen, Heng Zhang, Jinshu Huang, Hao Jiang, Hu Li, Song Yang

Summary: Water pollution is a pressing global environmental issue due to the presence of toxic organic pollutants. Photocatalysis, particularly using metal-organic frameworks (MOFs), has shown great promise for organic pollutant removal in wastewater treatment. This review summarizes recent advances in MOF-based photocatalysts, including preparation strategies, modification techniques, and applications for organic pollutant degradation. The working mechanisms, heterojunctions, and key parameters affecting the photocatalytic degradation process are also discussed. The future outlook and challenges of MOF materials for removing organic pollutants from water are emphasized.

ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Uncovering Original Z Scheme Heterojunctions of COF/MOx (M = Ti, Zn, Zr, Sn, Ce, and Nb) with Ascendant Photocatalytic Selectivity for Virtually 99.9% NO-to-NO3- Oxidation

Yujiao Zhang, Zhao Hu, Heng Zhang, Hu Li, Song Yang

Summary: A novel Covalent organic skeleton/metal oxide (COF/MOx) Z scheme heterojunction was constructed for selective oxidation of nitric oxide (NO). The optimized COF/TiO2 catalyst exhibited excellent NO removal rate (64.5%) under visible-light irradiation due to improved light absorption, efficient separation of photoexcited electron-hole pairs, and activation of O-2 by uniform COF coating. The selectivity towards nitrate (NO3-) was improved to 99.9% by enhancing the generation of superoxide radicals as the main reactive species and limiting the production of intermediate nitrogen dioxide (NO2). This study demonstrates the potential of the Z scheme heterojunction for universal applications.

ADVANCED FUNCTIONAL MATERIALS (2023)

添加到收藏夹

Article Chemistry, Physical

Synergistic electrocatalysis of crystal facet and O-vacancy for enhancive urea synthesis from nitrate and CO2

Zhengyi Li, Peng Zhou, Min Zhou, Hao Jiang, Hu Li, Shengqi Liu, Heng Zhang, Song Yang, Zehui Zhang

Summary: In this study, a new bifunctional indium hydroxide material was developed for the high-efficiency synthesis of urea from CO2 and nitrogenous pollutants. The material, with dual active sites and facet and defect engineering, showed selective catalytic activity for the conversion of CO2 and NO3-, leading to improved urea synthesis efficiency.

APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY (2023)

添加到收藏夹

Article Agronomy

Resistance-driven innovations in the discovery of bactericides: novel triclosan derivatives decorating isopropanolamine moiety as promising anti-biofilm agents against destructive plant bacterial diseases

Jiao-Jiao Zhang, Yu-Mei Feng, Jun-Rong Zhang, Wan-Lin Xiao, Shuai-Shuai Liu, Xiang Zhou, Heng Zhang, Pei-Yi Wang, Li-Wei Liu, Song Yang

Summary: A series of simple triclosan derivatives containing isopropanolamine moiety were designed and assessed for their antibacterial behavior. Some compounds showed excellent bioactivity against three destructive bacteria. Compound C-8 displayed high bioactivities towards Xoo and Xac.

PEST MANAGEMENT SCIENCE (2023)

添加到收藏夹

Article Agronomy

Discovery of phosphonate derivatives containing different substituted 1,2,3-triazole motif as promising tobacco mosaic virus (TMV) helicase inhibitors for controlling plant viral diseases

Zhenxing Li, Binxin Yang, Yue Ding, Xiang Zhou, Zimian Fang, ShuaiShuai Liu, Jie Yang, Song Yang

Summary: A series of phosphonate derivatives containing a 1,2,3-triazole motif were developed and evaluated for their antiviral activity against tobacco mosaic virus (TMV) helicase. The optimized B-17 showed stronger curative activity against TMV compared to the commercial drug Ribavirin. Additionally, B-17 exhibited potential antiviral activity against other viruses and pathogens.

PEST MANAGEMENT SCIENCE (2023)

添加到收藏夹

Article Agronomy

Novel cinnamic acid derivatives as a versatile tool for developing agrochemicals for controlling plant virus and bacterial diseases by enhancing plant defense responses

Bin-Xin Yang, Zhen-Xing Li, Shuai-Shuai Liu, Jie Yang, Pei-Yi Wang, Hong-Wu Liu, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang

Summary: Two series of novel cinnamic acid derivatives were designed and synthesized to explore alternative agrochemicals for controlling plant virus and bacterial diseases. The bioassay results showed that these derivatives exhibited excellent antiviral competence, with compound A(5) demonstrating remarkable protective effects against tobacco mosaic virus. This research provides a foundation for the practical application of cinnamic acid derivatives in pesticide exploration.

PEST MANAGEMENT SCIENCE (2023)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells

Hui Wu, Long-Shan Wang, Pei Li, Jia Yu, Sha Cheng, Gang Yu, Mashaal Ahmad, Xue-Ling Meng, Heng Luo, Bi-Xue Xu

Summary: A series of new N-aryl-2-trifluoromethylquinazoline-4-amine analogs were synthesized and their structures were confirmed. The anti-cancer activity of these compounds against different cancer cell lines was evaluated. Some of these compounds showed stronger growth inhibitory activity on certain cancer cells compared to positive controls. These compounds inhibited tubulin polymerization and disrupted cellular microtubule networks, leading to cell cycle arrest and cell apoptosis. These findings suggest that these compounds can be potential lead compounds for anti-leukemia agents.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Organic

Design, synthesis, antifungal activity, and molecular docking of novel trifluoromethyl pyrimidine derivatives containing 1,3,4-oxadiazole and thioether moieties as potential succinate dehydrogenase inhibitors

Nianjian Pan, Ruirui Wu, Chang Yan, Mei Zhou, Qiang Fei, Pei Li, Wenneng Wu

Summary: In this study, 20 novel trifluoromethyl pyrimidine derivatives containing 1,3,4-oxadiazole and thioether moieties were synthesized and characterized. Some of the target compounds showed moderate to good in vitro antifungal activities against various fungi. Compound 6g and 6i exhibited better antifungal activity against B. cinerea than Pyrimethanil, with EC50 values of 19.43 and 28.22 μg/mL, respectively. Compound 6r showed good antifungal activity against F. oxysporum, with an EC50 value of 3.61 μg/mL, lower than that of Boscalid. Molecular docking simulation indicated that compound 6r interacted with specific residues of SDH through hydrogen bonds.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis, Antifungal, and Antibacterial Activities of Novel Benzoylurea Derivatives Containing a Pyrimidine Moiety

Jiansong An, Wenjun Lan, Qiang Fei, Pei Li, Wenneng Wu

Summary: This study reports the antifungal and antibacterial activities of novel benzoylurea derivatives containing a pyrimidine moiety. Some of the compounds exhibited moderate to good in vitro antifungal activities against various fungi, and the interaction with succinate dehydrogenase was found to contribute to their mechanism of action.

MOLECULES (2023)

添加到收藏夹

Article Agronomy

Identification of natural Rutaecarpine as a potent tobacco mosaic virus (TMV) helicase candidate for managing intractable plant viral diseases

Zhen-Xing Li, Jin-Hong Hu, Rong-Shuang Luo, Tai-Hong Zhang, Yue Ding, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang

Summary: This study established an efficient screening platform based on natural alkaloids to discover novel compounds targeting TMV helicase. Rutaecarpine from Evodia rutaecarpa (Juss.) Benth showed excellent TMV helicase inhibitory properties (Kd = 1.1 μm, IC50 = 227.24 μm) and demonstrated strong anti-TMV activity. Molecular docking and dynamic simulations revealed that Rutaecarpine could stably bind to the active pockets of the helicase through hydrogen bonding and hydrophobic interactions with low binding energy (ΔG(bind) = -17.8 kcal/mol).

PEST MANAGEMENT SCIENCE (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of renewable isoindolines from bio-based furfurals

Feng Xu, Zao Li, Li-Long Zhang, Shengqi Liu, Hu Li, Yuhe Liao, Song Yang

Summary: Upgrading biomass-derived platforms to functionalized aromatics by a tandem Diels-Alder (DA) cycloaddition-aromatization strategy has attracted attention. Three challenges exist: improving the equilibrium of DA cycloaddition, controlling the regioselectivity of DA adducts, and increasing the stability of the cycloadduct. In this study, an intramolecular cycloaromatization strategy was developed using a defective Zn-BTC-SA catalyst and an acidic ionic liquid to achieve efficient and selective conversion of bio-furfurals to isoindolinones under liquid phase conditions. The protocol showed high yields and scalability.

GREEN CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Domino synthesis of bio-derived anethole over facile-prepared hafnium phosphonate frameworks with efficient bifunctional acid sites

Long Chen, Yixuan Liu, Heng Zhang, Yuncong Li, Songdang Zhang, Yulin Hu, Hu Li, Song Yang

Summary: Utilization of renewable biomass resources to produce value-added platform molecules, such as anethole, has attracted significant attention. In this study, a green and effective method for the stereoselective conversion of biomass-derived 4'-methoxyphenylacetone into trans-anethole was developed using a bifunctional acid catalyst. The catalyst exhibited a favorable structure with specific surface area, abundant mesopores, acidic sites, hydrophobicity, and stability. The optimized reaction conditions resulted in a high yield and excellent reusability. This catalytic strategy shows promise for the synthesis of anethole and other high-value molecules.

REACTION CHEMISTRY & ENGINEERING (2023)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Insights into elusive and cooperative multi-oxidant mechanisms in enabling catalytic methane-to-methanol conversion over atomically dispersed metals

Li-Long Zhang, Yaqiong Su, Dandan Chen, Hongguo Wu, Feng Xu, Hu Li, Song Yang

Summary: NOx is used as an oxidant for direct selective conversion of methane into methanol, but the interconversion of NOx compounds and the easy formation of O-2 have posed challenges in determining its effectiveness. This study proposes a new cooperative multi-functional mechanism strategy using dual oxidants (NO and N2O) to enhance catalytic performance. Compared with normal mechanisms, this strategy shows stronger CH4 adsorption and thermodynamic favorability. It is expected to inspire further research in DSCMM and other catalytic systems.

INORGANIC CHEMISTRY FRONTIERS (2023)

添加到收藏夹

Article Chemistry, Physical

High-efficiency purification of CH4 and H2 energy sources enabled by a phosphotungstic acid-supported Os single-atom catalyst

Li-Long Zhang, Ji Zheng, Jinxing Gu, Zhuochun Huang, Linguo Lu, Hu Li, Zhongfang Chen, Song Yang

Summary: This study investigated 11 phosphotungstic acid-supported single-atom catalysts (SACs) and found that Os-1/PTA SACs exhibited superior catalytic activity for the purification of methane and hydrogen, with the ease of oxidation following the CO > H-2 > CH4 order. It selectively removed CO in water and MeOH without consuming H-2, due to strong Os-PTA interactions and charge transfer mechanism.

JOURNAL OF MATERIALS CHEMISTRY A (2023)

添加到收藏夹

Review Polymer Science

Organic polymer facilitated CO2 photoreduction: a minireview

Wenfeng Zhao, Qinmei Ge, Hu Li, Nan Jiang, Shangwei Chen, Song Yang, Hang Cong

Summary: Using organic polymers as catalysts for CO2 photoreduction is a highly promising approach to addressing energy and environmental issues, due to their outstanding CO2 adsorption capacity, photochemical performance, and tunable structure.

POLYMER CHEMISTRY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dihydropyrimidine derivatives as MDM2 inhibitors

Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami

Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.

CHEMICAL BIOLOGY & DRUG DESIGN (2024)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.