Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery

Development of a Novel Noncompetitive Antagonist of IL-1 Receptor

(2014) C. Quiniou et al.   JOURNAL OF IMMUNOLOGY

Azapeptide Analogues of the Growth Hormone Releasing Peptide 6 as Cluster of Differentiation 36 Receptor Ligands with Reduced Affinity for the Growth Hormone Secretagogue Receptor 1a

(2012) Caroline Proulx et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclic Aza-peptide Integrin Ligand Synthesis and Biological Activity

(2012) Jochen Spiegel et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure Analysis of an Amyloid-Forming Model Peptide by a Systematic Glycine and Proline Scan

(2011) Ulla I. M. Gerling et al.   BIOMACROMOLECULES

Structure, function and regulation of the melanocortin receptors

(2011) Yingkui Yang   EUROPEAN JOURNAL OF PHARMACOLOGY

Azapeptides and their therapeutic potential

(2011) Caroline Proulx et al.   Future Medicinal Chemistry

Targeting the Prostaglandin F2α Receptor for Preventing Preterm Labor with Azapeptide Tocolytics

(2011) Carine B. Bourguet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted Solid-Phase Aza-peptide Synthesis: Aza Scan of a PKB/Akt Inhibitor Using Aza-arginine and Aza-proline Precursors

(2011) Noam S. Freeman et al.   JOURNAL OF ORGANIC CHEMISTRY

Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams

(2011) Nicolas Boutard et al.   JOURNAL OF PEPTIDE SCIENCE

Enhancement of the inhibitory effect of an IL-15 antagonist peptide by alanine scanning

(2011) Alicia Santos Savio et al.   JOURNAL OF PEPTIDE SCIENCE

Structure–Activity Relationships of GHRP-6 Azapeptide Ligands of the CD36 Scavenger Receptor by Solid-Phase Submonomer Azapeptide Synthesis

(2011) David Sabatino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insertion of multiple α-amino γ-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns

(2010) Luisa Ronga et al.   BIOPOLYMERS

Protein-protein interactions in transcription: A fertile ground for helix mimetics

(2010) Danielle A. Guarracino et al.   BIOPOLYMERS

NXO Building Blocks for Backbone Modification of Peptides and Preparation of Pseudopeptides

(2010) Constantin Rabong et al.   JOURNAL OF ORGANIC CHEMISTRY

Aza-1,2,3-triazole-3-alanine Synthesis via Copper-Catalyzed 1,3-Dipolar Cycloaddition on Aza-progargylglycine

(2010) Caroline Proulx et al.   JOURNAL OF ORGANIC CHEMISTRY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Copper-CatalyzedN-Arylation of Semicarbazones for the Synthesis of Aza-Arylglycine-Containing Aza-Peptides

(2010) Caroline Proulx et al.   ORGANIC LETTERS

Introduction of All-Hydrocarboni,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

(2010) Young-Woo Kim et al.   ORGANIC LETTERS

Synthetic mimetics of protein secondary structure domains

(2010) N. T. Ross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   CHEMBIOCHEM

Structure–Activity Analysis of the Growth Hormone Secretagogue GHRP-6 by α- and β-Amino γ-Lactam Positional Scanning

(2009) Nicolas Boutard et al.   Chemical Biology & Drug Design

Positional Scanning for Peptide Secondary Structure by Systematic Solid-Phase Synthesis of Amino Lactam Peptides

(2009) Andrew G. Jamieson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring Side-Chain Diversity by Submonomer Solid-Phase Aza-Peptide Synthesis

(2009) David Sabatino et al.   ORGANIC LETTERS

The Practice of Ring Constraint in Peptidomimetics Using Bicyclic and Polycyclic Amino Acids

(2008) Stephen Hanessian et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Methyl Scanning Mutagenesis Generates Protease-Resistant G Protein Ligands with Improved Affinity and Selectivity

(2008) Stephen V. Fiacco et al.   CHEMBIOCHEM

Mapping and Characterization of the Binding Site for Specific Oxidized Phospholipids and Oxidized Low Density Lipoprotein of Scavenger Receptor CD36

(2008) Niladri S. Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

(2008) Les P. Miranda et al.   JOURNAL OF MEDICINAL CHEMISTRY

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Synthesis of N′-substituted Ddz-protected hydrazines and their application in solid phase synthesis of aza-peptides

(2008) Noam S. Freeman et al.   TETRAHEDRON