期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 80, 期 6, 页码 929-936出版社
WILEY
DOI: 10.1111/cbdd.12044
关键词
coumarin derivatives; multicomponent reaction; Mycobacterium bovis
资金
- Pasteur institute of Iran
- Ministry of Health and Medical Education in Iran [456]
The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one-pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide-based multicomponent condensation reactions. These compounds were evaluated for anti-mycobacterium activity against Mycobacterium bovis (Bacillus CalmetteGuerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti-tuberculosis activity.
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