Article
Pharmacology & Pharmacy
Niloufar Hosseini-Giv, Ahmad Reza Bahrami, Maryam M. Matin
Summary: BDEPT is a novel targeted therapy method that uses bacteria as enzyme carriers to convert a pro-drug to a drug specifically within the tumor site, aiming to reduce the side effects of chemotherapy. Studies have shown potential effectiveness of BDEPT in 4T1 breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Yujie Liu, Panpan Zhou, Zeying Cao, Wanhui Liang, Jiazhi Yan, Huipeng Xu, Li Wu, Lixin Sun, Likun Gong, Can Peng, Tao Guo, Caifen Wang, Jiwen Zhang
Summary: The inclusion and nanocluster formed in CD-MOF can improve the solubility and bioavailability of insoluble drugs. This study shows that GA@nano-CD-MOF has enhanced bioavailability and unique biphasic release kinetics, allowing for more flexible pharmaceutical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Gastroenterology & Hepatology
Xia Li, Xiao-Ling Ma, Yi Nan, Yu-Hua Du, Yi Yang, Dou-Dou Lu, Jun-Fei Zhang, Yan Chen, Lei Zhang, Yang Niu, Ling Yuan
Summary: The study aimed to explore the molecular mechanism of 18 beta-glycyrrhetinic acid (18 beta-GRA) in inhibiting the proliferation of gastric cancer (GC) cells through regulating the miR-345-5p/TGM2 signaling pathway. Various experimental methods were used, and the results showed that 18 beta-GRA could inhibit GC cells viability, promote apoptosis, block cell cycle, reduce cell migration ability, and promote autophagy. Further analysis revealed that 18 beta-GRA could down-regulate TGM2 expression and up-regulate miR-345-5p expression, and miR-345-5p inhibited GC cell proliferation by suppressing TGM2 expression. Therefore, 18 beta-GRA inhibits GC cell proliferation and promotes autophagy through regulating the miR-3455p/TGM2 signaling pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Neurosciences
Hanyue Luo, Caishi Zhang, Lujuan He, Zefang Lin, Ji-chun Zhang, Qi Qi, Jia-xu Chen, Wei Yao
Summary: In this study, the therapeutic effects of 18 beta-GA in Parkinson's disease were investigated. It was found that 18 beta-GA has anti-inflammatory effects and can mitigate neurotoxicity induced by MPTP. Additionally, 18 beta-GA protects BDNF levels, suggesting its potential as a new therapeutic agent for PD.
PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Fan, Yanxiang Gao
Summary: The study found that the Maillard reaction increased antioxidant activity in subcritical water extraction, and the behaviors and kinetic parameters of different reactions were analyzed. Furthermore, the degree of the Maillard reaction increased with the rise of extraction temperature.
Article
Chemistry, Multidisciplinary
Kaize Su, Jiahao Li, Xiaoyu Guo, Shengzhu Guo, Wende Zheng, Xiaowen Tang, Duanyu Deng, Huiji Yang, Wing-Leung Wong, Song Ang, Kun Zhang, Panpan Wu
Summary: In this study, a series of novel metallo-hydrogels composed of GA-O-09 derivative (GA-O-09) with rare earth metal ions (Ce3+, Tb3+, Eu3+ and La3+) were successfully constructed. These metallo-hydrogels exhibited excellent thermodynamic stability and pH stability, and showed remarkable fluorescence enhancement in detecting histidine (His), providing a potential application for highly selective and sensitive detection of His.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Plant Sciences
Pottathil Shinu, Girdhari Lal Gupta, Manu Sharma, Shahzad Khan, Manoj Goyal, Anroop B. B. Nair, Manish Kumar, Wafaa E. E. Soliman, Aminur Rahman, Mahesh Attimarad, Katharigatta N. N. Venugopala, Abdullah Abdulhamid Ahmed Altaweel
Summary: Licorice, known as Glycyrrhiza glabra L., is a medicinal plant with the active component 18 beta GA, which has various pharmacological activities. This review examines the research on 18 beta GA in recent decades, demonstrating its therapeutic potential and possibilities for future drug development.
Article
Biochemistry & Molecular Biology
Khaled AbouAitah, Urszula Piotrowska, Jacek Wojnarowicz, Anna Swiderska-Sroda, Ahmed H. H. El-Desoky, Witold Lojkowski
Summary: Hybrid nanostructures combining zinc oxide nanoparticles and the natural antibacterial agent protocatechuic acid demonstrated sustained release and effective antibacterial effects against Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
I-Shan Chen, Jumpei Yasuda, Takuya Notomi, Tomoe Y. Nakamura
Summary: Licorice ingredients can inhibit or activate GIRK channel activity, which may affect atrial function.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Engineering, Chemical
Saeed Mahdavy, Hamid Reza Norouzi, Christian Jordan, Bahram Haddadi, Michael Harasek
Summary: This study characterizes the motion of non-spherical particles with sharp edges using residence time distribution (RTD) measurement in a continuous drum. The effects of rotation speed, incline angle, feed rate, and mixture composition on the RTD were investigated. The study also found that the average residence time of particles with sharp edges depends on rotation speed and incline angle, while the effects of feed rate and particle size are minimal.
Article
Biochemistry & Molecular Biology
Yihong Yang, Kunlun Chen, Guangdi Wang, Hongwu Liu, Lihui Shao, Xiang Zhou, Liwei Liu, Song Yang
Summary: Developing new agricultural bactericides is a feasible strategy for preventing the increase in resistance of plant pathogenic bacteria. In this study, pentacyclic triterpene acid derivatives were synthesized and compound A(22) showed the best antimicrobial activity against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac). The antimicrobial mechanism of A(22) was also investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shuobin Liang, Xinyuan Ma, Man Li, Yanliang Yi, Qianqian Gao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao
Summary: In this study, a series of heptavalent glycyrrhetinic acid derivatives based on beta-cyclodextrin scaffold were designed and synthesized using click chemistry. The synthesized compounds showed promising inhibitory activity against influenza virus infection, making them potential candidates for influenza entry inhibitors.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Guangwei Yang, Longxiang Tao, Guijie Kang, Jinhao Yan, Kewu He, Xuefu Wang, Jun Yin
Summary: A series of polyprodrug amphiphiles with high drug content and targeting peptides were constructed. These polyprodrug amphiphiles could self-assemble into spherical nanoparticles and expose targeting peptides under tumor microenvironment, promoting the endocytosis of nanoparticles. The drug molecules could be efficiently released by a cascade amplification reaction in the presence of intracellular glutathione, leading to the killing of cancer cells. This study demonstrates that these nanoreagents have a highly inhibitory effect on tumors and can activate the immune system for continuous immune protection.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shou-yan Wu, Wen-jie Wang, Jin-hui Dou, Li-kun Gong
Summary: Licorice, commonly prescribed in Chinese herbal medicine, has been utilized for centuries and is known as a national treasure in China. Its active component, 18 beta-glycyrrhetinic acid, has been extensively studied for its antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection properties, offering potential benefits for liver diseases and other health conditions.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Environmental Sciences
Ching-Huei Kuo, Pi-Yi Li, Jun-Yi Lin, Yi-Lin Chen
Summary: This paper presents a water circulation model in a high-temperature metamorphic geothermal field in Taiwan. The study combines oxygen and hydrogen stable isotopes and mean residence time estimation to analyze the variation patterns and estimate the mean residence time of groundwater. The results show that there are two circulation systems with different recharge altitudes and isotopic values. The study demonstrates the usefulness of the combined usage of stable isotopes and MRT in understanding water circulation in different temperature geothermal fields.
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)
