Article
Biochemistry & Molecular Biology
Xiao-Jing Liu, Hou-Jin Li, Wen-Zhe Ma, Fu-Ming Zhang, Meng-Yang Xu, Taifo Mahmud, Wen-Jian Lan
Summary: The article presents the isolation and characterization of four new oxidized phomaligol derivatives, along with seven known compounds, from the culture of the fungus Aspergillus flavus BB1 isolated from marine shellfish in China. The new compounds were identified through various analytical techniques and tested for cytotoxic activity, with compound 8 showing potent inhibitory activity against multiple cancer cell lines. Additionally, compound 8 was found to induce apoptosis of HCT116 cells in a dose-dependent manner.
BIOORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yaru Gao, Xinyang Du, Huanhuan Li, Ying Wang
Summary: Marine microorganisms have unique physicochemical characteristics compared to terrestrial microorganisms, producing diverse secondary metabolites (SMs). Three strains of coepiphytic Aspergillus with potential antibacterial activities were isolated from the South China Sea, with A7 showing the highest diversity of biosynthetic gene clusters (BGCs) and superior environmental adaptability. The study provides genetic information for investigating marine Aspergillus spp., potentially elucidating their chemical diversity and adaptive strategies.
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Yao Xiang, Qi Zeng, Zhi-Mao Mai, Yu-Chan Chen, Xue-Feng Shi, Xia-Yu Chen, Wei-Mao Zhong, Xiao-Yi Wei, Wei-Min Zhang, Si Zhang, Fa-Zuo Wang
Summary: Three new tricyclic cyclopiazonic acid (CPA) related alkaloids, asperorydines N-P (1-3), were isolated from the fungus Aspergillus flavus SCSIO F025, along with six known compounds. Compound 9 exhibited significant radical scavenging activities against DPPH and broad-spectrum cytotoxicities against four tumor cell lines, while compounds 4-9 showed weak antimicrobial activities against E. coli.
Article
Plant Sciences
Xiang Guo, Qinyu Meng, Jie Liu, Jingshuai Wu, Hongli Jia, Dong Liu, Yucheng Gu, Jianrong Liu, Jian Huang, Aili Fan, Wenhan Lin
Summary: Bioassay-guided fractionation, combined with LC-MS and NMR detection, led to the discovery of six new alkaloids from a marine gorgonian-derived fungus. Among them, sclerotiamides C and F showed significant inhibition against tumor cell lines, and sclerotiamide C induced apoptosis in cervical cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Chun-Ju Lu, Zhen-Zhou Tang, Zhi-Wei Su, Hai-Yan Li, Geng-Si Zhang, Cheng-Hai Gao, Yong-Hong Liu, Xin-Ya Xu
Summary: Two new compounds, carneusins A-B (1-2), and fifteen known compounds (3-17) were isolated from the marine-derived fungus Aspergillus carneus GXIMD00519. Their structures were determined through spectroscopic analysis and quantum chemistry calculations. The compounds were tested for antibacterial, antibiofilm, and cytotoxic effects, and showed potential in these activities.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Yang Liu, Lijian Ding, Yutong Shi, Xiaojun Yan, Bin Wu, Shan He
Summary: In this study, two rare tetracyclic skeleton alkaloids named perinadines B and C were isolated from the marine-derived Aspergillus sp. LS116 using molecular networking. The compounds showed moderate antibacterial activity against Bacillus subtilis and were evaluated for anti-inflammatory activities in an in vivo zebra fish model.
Article
Chemistry, Medicinal
Muh. Ade Artasasta, Yanwirasti Yanwirasti, Muhammad Taher, Akmal Djamaan, Ni Putu Ariantari, Ru Angelie Edrada-Ebel, Dian Handayani
Summary: Fungi derived from sponges, particularly Aspergillus nomius NC06, have been found to produce bioactive compounds with cytotoxic activity against colon cancer cells. Compounds 1, 2, and 4 from this fungus were able to induce apoptosis and cell death in HT 29 cells.
Article
Biotechnology & Applied Microbiology
Xuan Hong, Xiaoqing Guan, Qiliang Lai, Dehua Yu, Zhongwei Chen, Xiaoteng Fu, Beibei Zhang, Changkun Chen, Zongze Shao, Jinmei Xia, Jiang-Jiang Qin, Weiyi Wang
Summary: A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus, and its structure and activity were studied. Compound 1 showed inhibitory activity against gastric cancer cells and certain bacteria.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Xiao Yang, Hongjia Yu, Jinwei Ren, Lei Cai, Lijian Xu, Ling Liu
Summary: Phytopathogens pose a significant threat to crops and human health, but marine-derived fungi offer potential anti-phytopathogenic drugs. A new compound, aspersydosulfoxide A, and several known compounds were isolated from a marine-derived fungus. These compounds showed antimicrobial and antinematodal activities, indicating their potential use in crop protection.
Article
Chemistry, Medicinal
Jin Cai, Xiao-Chen Zhu, Wei-Nv Zeng, Bin Wang, You-Ping Luo, Jing Liu, Min-Jing Chen, Gao-Yu Li, Guo-Lei Huang, Guang-Ying Chen, Jing Xu, Cai-Juan Zheng
Summary: Six new isocoumarin derivative compounds along with 17 known analogues were isolated from a mangrove-derived fungus. Their structures were identified and their biological activities, including antioxidant and alpha-glucosidase inhibitory activities, were tested. Some compounds showed promising antioxidant and alpha-glucosidase inhibitory activities, highlighting their potential as antioxidants and diabetes control agents.
Article
Chemistry, Medicinal
Rong Chao, Gulab Said, Qun Zhang, Yue-Xuan Qi, Jie Hu, Cai-Juan Zheng, Ji-Yong Zheng, Chang-Lun Shao, Guang-Ying Chen, Mei-Yan Wei
Summary: To enhance the biological activity of geodin, a natural product from marine-derived fungus, a series of new ether derivatives were designed and synthesized. These derivatives showed improved insecticidal activity against Helicoverpa armigera and strong antibacterial activity against Staphylococcus aureus and Aeromonas salmonicida. The introduction of halogenated benzyl and substitution of 4-OH were found to be key factors in increasing the activity of geodin.
Article
Chemistry, Medicinal
Kai Zhang, Xinwan Zhang, Rui Lin, Haijin Yang, Fuhang Song, Xiuli Xu, Long Wang
Summary: Seven new compounds and seven known compounds were isolated from a marine-derived fungus, Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. The new compounds possess a novel carbon skeleton and were tested for their bioactivities against bacteria and fungi.
Article
Biochemistry & Molecular Biology
Zhong-Hui Huang, Xiao Liang, Qiong Gu, Xuan Ma, Shu-Hua Qi
Summary: Seven undescribed polyhydroxylated mycoecdysteroids, punicesterones A-G, and two known analogues were isolated from a deep-sea-derived fungal strain. The structures and absolute configurations of these compounds were determined through NMR spectroscopic analysis, HRESIMS data, and single-crystal X-ray diffraction experiments. Punicesterone A was found to have a nicotinoyl unit at C-22 of the typical ecdysteroid skeleton. The isolated compounds were evaluated for their anti-inflammatory, lipid-lowering, and antibacterial activities, with punicesterones B and C showing promising results.
Article
Chemistry, Applied
Huiling Wen, Yi Zang, Qianheng Zhu, Sheng Ouyang, Juanjuan Luo, Nianhua Luo, Hucheng Zhu, Yonghui Zhang
Summary: This article reports the isolation and structural elucidation of two new compounds from a marine-derived fungus, as well as the evaluation of their biological activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemical Research Methods
Ingrid V. Farias, Clarissa Krieger Amorin, Milena Guimaraes dos Santos, Carmem Lucia dos Santos Machado, Favero Reisdorfer Paula, Louis P. Sandjo, Angela Malheiros, Christiane Meyre-Silva, Tania Mari Belle Bresolin
PHYTOCHEMICAL ANALYSIS
(2020)
Article
Chemistry, Multidisciplinary
Frederic Nana, Victor Kuete, Valentin Zaharia, Bathelemy Ngameni, Louis P. Sandjo
Article
Pharmacology & Pharmacy
Fernanda Cristina Stenger Moura, Carmem Lucia dos Santos Machado, Favero Reisdorfer Paula, Angelica Garcia Couto, Maurizio Ricci, Valdir Cechinel-Filho, Tiago J. Bonomini, Louis P. Sandjo, Tania Mari Belle Bresolin
Summary: Taxifolin, isolated from the seeds of Mimusops balata, was found to be extremely unstable under alkaline hydrolysis and its thermal degradation was increased by humidity. However, it displayed stability in terms of photosensitivity. Alkaline degradation products were identified as dimers of taxifolin. These findings contribute to the development of stability-indicating methods and appropriate drug release systems to preserve its stability and enhance bioavailability.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Chemistry, Applied
Luis Eduardo Silva Nascimento, Nathalia Darminia Aceval Arriola, Layzon Antonio Lemos da Silva, Larissa Gabriela Faqueti, Louis Pergaud Sandjo, Carlos Eduardo Salles de Araujo, Maique Weber Biavatti, Jorge Luiz Barcelos-Oliveira, Renata Dias de Mello Castanho Amboni
Article
Plant Sciences
Amanda Ellen de Athayde, Carlos Eduardo Salles de Araujo, Louis Pergaud Sandjo, Maique Weber Biavatti
Summary: This study aimed to compare the main plants recognized as arnica in Brazil using metabolomic analysis. The research utilized UPLC-ESI-QTof-MS2 data and multivariate statistical analysis to identify chemical similarities and differences among these plants. The results showed that some species have similar chemical features to Arnica montana, while others are chemically diverse. The study concluded that mass spectrometry combined with multivariate statistical analysis is a valuable tool for identifying correlated compounds and verifying chemical similarity among different plant species.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Microbiology
Luiz A. E. Pollo, Erlon F. Martin, Vanessa R. Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J. Waddell, Maique W. Biavatti, Louis P. Sandjo
Summary: The study tested a library of 52 natural and synthetic compounds and identified seven compounds with antimycobacterial activity, suggesting new avenues for drug discovery.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Mariana Bottamedi, Marcus Vinicius Pereira dos Santos Nascimento, Eduarda Fratoni, Yeo Jim Kinoshita Moon, Larissa Faqueti, Tiago Tizziani, Louis P. Sandjo, Alexandre Siminski, Eduardo Monguilhott Dalmarco, Beatriz Garcia Mendes
Summary: The trunk bark extract of Myrocarpus frondosus exhibits good antioxidant activity and anti-inflammatory effects, showing potential value in inhibiting inflammation and alleviating damage caused by inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Microbiology
Rafael Dorighello Cadamuro, Isabela Maria Agustini da Silveira Bastos, Izabella Thais Silva, Ariadne Cristiane Cabral da Cruz, Diogo Robl, Louis Pergaud Sandjo, Sergio Alves, Jose M. Lorenzo, David Rodriguez-Lazaro, Helen Treichel, Mario Steindel, Gislaine Fongaro
Summary: Mangroves are unique ecosystems known for their high salinity and organic matter, hosting a rich biodiversity. Fungi, particularly endophytic fungi isolated from mangrove plant species, are an important natural source for discovering new bioactive compounds with potential biotechnological and pharmacological applications. These bioactive compounds show promising bioactivity against protozoa, bacteria, and pathogenic viruses, highlighting the importance of mangrove ecosystems for preservation and as a source of new molecules for controlling pathogens that impact human, animal, and environmental health.
Article
Agriculture, Multidisciplinary
Layzon A. Lemos da Silva, Amanda E. de Athayde, Monalisa A. Moreira, Tiago Tizziani, Stephanie Gkionis, Lucas da Silva, Maique W. Biavatti, Ana Carolina R. de Moraes, Marcus V. P. da Santos Nascimento, Eduardo M. Dalmarco, Louis P. Sandjo
Summary: This study investigated the chemical profiles, anti-inflammatory, and antiplatelet activity of young rangpur fruits using UPLC-ESI-MS. The results showed that the extracts obtained from these young fruits exhibited considerable anti-inflammatory and antiplatelet activity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Physical
Erlon Ferreira Martin, Luiz Antonio Escorteganha Pollo, Layzon Antonio Lemos da Silva, Maique Weber Biavatti, Louis Pergaud Sandjo
Summary: Alzheimer's disease is a prevalent neurodegenerative disease, and a compound family called pyranochromenes has shown potential as inhibitors of acetylcholinesterase, making them promising candidates for the development of new drugs against Alzheimer's disease.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Lucas Pradi, Tassiane E. S. Andrade, Jhuly W. F. Lacerda, Jhenifer Karvat, Larissa M. Beppler, Tiago Tizziani, Adair R. S. Santos, Louis P. Sandjo
Summary: The hydroalcoholic extract of Polygala altomontana showed a dose-dependent antinociceptive action in the inflammatory phase of the formalin test and anti-hyperalgesic action in a mechanical nociception model. UPLC-ESI-QTOF-MS analysis revealed the presence of phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins in the active extract. Some identified compounds, such as styrylpyrones and coumarins, have demonstrated antinociceptive action. The results suggest the potential of P. altomontana for developing pain-relieving herbal remedies and drugs.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Layzon A. Lemos da Silva, Louis P. Sandjo, Laura S. Assuncao, Anne N. Prigol, Carolina D. de Siqueira, Tania B. Creczynski-Pasa, Marcus T. Scotti, Luciana Scotti, Fabiola B. Filippin-Monteiro, Maique W. Biavatti
Summary: This study investigates the sensitivity of semisynthetic sesquiterpene lactone (SL) derivatives by preparing them under different pH conditions and evaluating their anti-inflammatory and antiproliferative activities. Results indicate that some of these derivatives exhibit significant cytotoxic activity and selectivity against human melanoma cells. They also demonstrate the ability to reduce the release of interleukin-6 (IL-6) and nitrite (NOx) in pre-treated macrophages. Overall, the study suggests that acidic and alkaline extraction processes can promote the formation of SLs.
Article
Microbiology
Rafael Dorighello Cadamuro, Isabela Maria Agustini da Silveira Bastos, Ana Claudia Oliveira de Freitas, Marilene da Silva Rosa, Geovanna de Oliveira Costa, Izabella Thais da Silva, Diogo Robl, Patricia Hermes Stoco, Louis Pergaud Sandjo, Helen Treichel, Mario Steindel, Gislaine Fongaro
Summary: The aim of this study was to identify the chemical profile of endophytic fungi Neofusicoccum parvum and Buergenerula spartinae isolated from Avecinnia schaueriana and Laguncularia racemosa. Solid-state fermentation and extraction were performed to obtain crude extracts, which were then evaluated through cytotoxicity and bacteriostatic assays. The results suggest that these endophytic fungi species with distinct chemical profiles represent a promising area for further exploration of new biomolecules.
Review
Chemistry, Medicinal
Leseho Swana, Bienvenu Tsakem, Jacqueline V. Tembu, Remy B. Teponno, Joy T. Folahan, Jarmo-Charles Kalinski, Alexandros Polyzois, Guy Kamatou, Louis P. Sandjo, Jean Christopher Chamcheu, Xavier Siwe-Noundou
Summary: This review provides an overview of the distribution, ethnobotanical uses, phytochemistry, and bioactivities of Dacryodes species. It highlights the pharmacological potential of Dacryodes edulis in the treatment of various diseases, including cancer, diabetes, inflammation, and liver diseases. However, further research is needed to fully explore the therapeutic potentials of the genus Dacryodes.
Article
Chemistry, Applied
Geovanna de Oliveira Costa, Amanda Tavares Germano, Lizandra Czermainski Bretanha, Gustavo Amadeu Micke, Xavier Siwe-Noundou, Louis Pergaud Sandjo
Summary: This study analyzed the chemical characteristics and fatty acid profiles of the waste from grey mullet and tambaqui fish. The analysis showed that both types of waste contained saturated, monounsaturated, and polyunsaturated fatty acids, but their compositions were slightly different. Grey mullet had higher levels of saturated fatty acids, while tambaqui had higher levels of monounsaturated and polyunsaturated fatty acids.
NATURAL PRODUCT RESEARCH
(2023)
