期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 58, 期 6, 页码 788-793出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.788
关键词
polybromothymol blue-modified electrode; electrocatalysis; ascorbic acid; dopamine; uric acid
资金
- National High Technology Investigation Project Foundation of China [2008AA02Z433]
- National Natural Science Foundation of China [20805006, 20975021]
- Fujian Provincial Important Science and Technology Foundation [208Y0045]
- Startup Foundation for Advanced Talents of Fujian Medical University [BS06002]
- Fujian Medical University [09ZD013]
- Nursery Foundation of Fujian Medical University [2010MP043]
- Natural Science Foundation of Fujian Province of China [C0710024]
A sensitive and selective electrochemical method for simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA) using an electropolymerized bromothymol blue (BTB)-modified glassy carbon electrode (GCE) was developed. The electrochemically synthesized film was investigated using electrochemical impedance spectroscopy and voltammetric methods. The electrochemical behavior of the polymer-modified electrode depends on film thickness, i.e., the electropolymyerization time. The poly-BTB-modified GCE shows excellent electrocatalytic activity toward the oxidation of AA, DA, and UA in phosphate buffer solution (pH 5.0). The voltametric peak separations of AA/DA, DA/UA, and AA/UA on this modified electrode are 118 mV, 298 mV, and 455 mV, respectively. Therefore the voltammetric responses of these three compounds can be resolved well on the polymer-modified electrode, and simultaneous determination of these three compounds can be achieved. In addition, this modified electrode can be successfully applied to determine AA and DA in injection and UA in urine samples without interference.
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