期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 57, 期 11, 页码 1227-1230出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.1227
关键词
Euphorbiaceae; herpes simplex virus type 1; antioxidant; antityrosinase
资金
- National Science Council, Taiwan, Republic of China [NSC 96-2628-M006-002]
Chemical investigation oil the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of I and 2 were elucidated oil the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type I (HSV-1) assay norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of sonic isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyrinoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 mu M, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 mu M.
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