4.3 Article

Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells

期刊

CHEMICAL & PHARMACEUTICAL BULLETIN
卷 56, 期 12, 页码 1722-1724

出版社

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1722

关键词

Dalbergia odorifera; Leguminosae; flavonoid; arylbenzofuran

资金

  1. Plant Diversity Research Center of the 2 1 st Century Frontier Research Program [0320401-00]
  2. Ministry of Science and Technology of the Korean Government

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Two flavonoids, 4,2',5'-trihydroxy-4'-methoxychalcone (1) and (2S)-6,7,4'-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.

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