期刊
JOURNAL OF FORENSIC SCIENCES
卷 60, 期 3, 页码 721-726出版社
WILEY-BLACKWELL
DOI: 10.1111/1556-4029.12712
关键词
forensic science; 4-methylpentedrone; legal high; cathinone; analog; 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone; 1-(4-methylphenyl)-2-(propylamino)-1-butanone; gas chromatography-mass spectroscopy; nuclear magnetic resonance
资金
- National Science Foundation's Research Experiences for Undergraduates Program [1261322]
- Direct For Social, Behav & Economic Scie
- SBE Off Of Multidisciplinary Activities [1261322] Funding Source: National Science Foundation
Online vendors are offering a new legal high, 4-methylpentedrone (4-MPD). Information for potential users provided by internet vendors of 4-MPD includes incorrect structures and nonexistent CAS numbers. A sample of 4-MPD was obtained and analyzed using GC-MS, NMR, and LC-EIS. The fragmentation data from the GC-MS and LC-EIS produced an M-1 ion that suggested the molecular mass was 219amu, rather than 205amu as calculated for 4-methylpentedrone. The difference in molecular mass corresponded to the addition of a methyl group. Based on the mass and fragmentation pattern, two standards were synthesized, 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone and 1-(4-methylphenyl)-2-(propylamino)-1-butanone. The synthesis involved bromination of the appropriate ketone followed by the reaction with ethylamine or propylamine. Based on the NMR data and unique fragmentation patterns produced by these molecules, the sample was identified as 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone, not 4-methylpentedrone.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据