Enantioselective Synthesis of (R)-2-Arylpropanenitriles Catalysed by Ene-Reductases in Aqueous Media and in Biphasic Ionic Liquid-Water Systems

Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

(2013) Marian C. Bryan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases

(2013) Christoph K. Winkler et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Protonation of Silyl Ketene Imines

(2013) Joyram Guin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme engineering toolbox – a ‘catalyst’ for change

(2013) Helen S. Toogood et al.   Catalysis Science & Technology

Old Yellow Enzyme-mediated reduction of β-cyano-α,β-unsaturated esters for the synthesis of chiral building blocks: stereochemical analysis of the reaction

(2013) Elisabetta Brenna et al.   Catalysis Science & Technology

Steric Effects on the Stereochemistry of Old Yellow Enzyme-Mediated Reductions of Unsaturated Diesters: Flipping of the Substrate within the Enzyme Active Site Induced by Structural Modifications

(2012) Elisabetta Brenna et al.   ADVANCED SYNTHESIS & CATALYSIS

Cascade Coupling of Ene Reductases with Alcohol Dehydrogenases: Enantioselective Reduction of Prochiral Unsaturated Aldehydes

(2012) Elisabetta Brenna et al.   ChemCatChem

Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities

(2012) Shizuo Kasai et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the stereochemistry of the Baker's Yeast-mediated reduction of regioisomeric unsaturated aldehydes: Examples of enantioselectivity switch promoted by substrate-engineering

(2012) Elisabetta Brenna et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enhancements of enantio and diastereoselectivities in reduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by microorganisms in ionic liquid/water biphasic system

(2012) Dávila S. Zampieri et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles

(2012) Junwon Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of α-Aryl Nitriles through Palladium-Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates

(2011) Rui Shang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Productivity enhancement of CC bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

(2011) Elisabetta Brenna et al.   CHEMICAL COMMUNICATIONS

Biocatalyzed Enantioselective Reduction of Activated C=C Bonds: Synthesis of Enantiomerically Enriched α-Halo-β-arylpropionic Acids

(2011) Elisabetta Brenna et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enoate Reductase-Mediated Preparation of Methyl (S)-2-Bromobutanoate, a Useful Key Intermediate for the Synthesis of Chiral Active Pharmaceutical Ingredients

(2011) Elisabetta Brenna et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors

(2011) Alessio Moriconi et al.   ACS Medicinal Chemistry Letters

Toward advanced ionic liquids. Polar, enzyme-friendly solvents for biocatalysis

(2010) Johnathan Gorke et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Ionic liquids in biotransformations: from proof-of-concept to emerging deep-eutectic-solvents

(2010) Pablo Domínguez de María et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation

(2009) Anna Fryszkowska et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent advances of enzymatic reactions in ionic liquids

(2009) Muhammad Moniruzzaman et al.   BIOCHEMICAL ENGINEERING JOURNAL

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ionic liquids in biotechnology: applications and perspectives for biotransformations

(2008) Christoph Roosen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Asymmetric Bioreduction of Activated C=C Bonds UsingZymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts

(2008) Mélanie Hall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Practical Synthesis of a Vanilloid Receptor-1 Antagonist

(2008) Oliver R. Thiel et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

(2008) Birgit Kosjek et al.   TETRAHEDRON-ASYMMETRY

Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats

(2007) M M Barsante et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-Isopropylsulfinylimines as Useful Intermediates in the Synthesis of Chiral Amines:  Expeditive Asymmetric Synthesis of the Calcimimetic (+)-NPS R-568

(2007) Inmaculada Fernández et al.   JOURNAL OF ORGANIC CHEMISTRY