Article
Chemistry, Physical
Swapna M. Gade, Vitthal B. Saptal, Bhalchandra M. Bhanage
Summary: This review discusses the synthesis, properties, and applications of glycerol carbonate (GC). The conversion of glycerol (GLY) to GC via transesterification is considered the most promising route. The effects of catalysts and operating conditions on GC yield are summarized, and future directions for GC production are discussed.
CATALYSIS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xiang-Lei Han, Bin Hu, Chao Fei, Zhe Li, Yang Yu, Cheng Cheng, Bruce Foxman, Jisheng Luo, Li Deng
Summary: This study reports an unprecedented catalytic asymmetric cross-coupling reaction that allows a variety of ketimines and aldimines to react, resulting in the direct synthesis of chiral vicinal diamines. This reaction is enabled by the development of a new chiral ammonium catalyst, which leads to highly diastereo- and enantioselective formation of diverse chiral vicinal diamines. It establishes a new approach for the asymmetric synthesis of chiral vicinal diamines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Michael J. Tilby, Damien F. Dewez, Adrian Hall, Carolina Martinez Lamenca, Michael C. Willis
Summary: In this study, the absolute configuration of sulfur-stereogenic aza-sulfur derivatives was determined using a unique feature of sulfonimidamides. Enantioselective alkylation was achieved by generating prochiral ions from sulfonimidamides with the help of a bis-quaternized phase-transfer catalyst. This demonstrates the potential of using configurationally labile aza-sulfur species in asymmetric catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Chemical
Siddhi Jaiswal, Gitanjali Pradhan, Yogesh Chandra Sharma
Summary: The study synthesized a highly efficient heterogeneous catalyst Li/TiO2 for the transesterification of glycerol with DMC, achieving a maximum conversion rate of 95.5% and a selectivity of 95.9% towards glycerol carbonate. The research demonstrates Li/TiO2 as an effective catalyst for converting glycerol to glycerol carbonate.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Organic
Masahiro Hosoya, Atsushi Manaka, Shogo Nishijima, Naoki Tsuno
Summary: This paper discusses a liquid-liquid biphasic flow reaction system, highlighting the influence of tube diameter, mixer size, and pump mechanism on reaction rate and formation of slug-flow. Technical difficulties with slug-flow may hinder scale-up, and using a Taylor vortex flow reactor is recommended for higher reaction rates.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zi-Tong Pan, Xu-Kuan Qi, Qian Xiao, Xi-Wen Liang, Jian-Ji Zhong, Jing-Xin Jian, Qing-Xiao Tong
Summary: In this study, we have demonstrated a regulable cross-coupling reaction using alcohols as alkylating reagents to functionalize benzothiazoles. We obtained two types of cross-coupling products with high isolated yields, opening up a broad research prospect for expanding alcohols as alkylating reagents.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Boossayamas Topool, Manop Charoenchaitrakool, Kandis Sudsakorn
Summary: This study proposes a facile method to prepare an effective, low-cost, and easily prepared catalyst from wasted pineapple peels. The catalysts were prepared by calcination of dried pineapple peel powders in air at temperatures between 300-800 degrees C. The catalysts were characterized using various techniques, and it was found that the catalyst prepared at 600 degrees C showed the highest basicity and activity. Using this catalyst, the highest glycerol conversion of 92.85% and glycerol carbonate yield of 90.29% were achieved under optimal conditions.
TOPICS IN CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Anna S. Tovmasyan, Anna F. Mkrtchyan, Hamlet N. Khachatryan, Mary V. Hayrapetyan, Robert M. Hakobyan, Artavazd S. Poghosyan, Avetis H. Tsaturyan, Ela V. Minasyan, Victor I. Maleev, Vladimir A. Larionov, Armen G. Ayvazyan, Norio Shibata, Giovanni N. Roviello, Ashot S. Saghyan
Summary: A new family of Cu(II) and Ni(II) salen complexes was synthesized and characterized. These complexes were evaluated for their catalytic activity in the C-alpha-alkylation reaction of Schiff bases. It was found that introducing a chlorine atom into the phenyl ring of the substrate increased both the chemical yield and asymmetric induction. The highest enantiomeric excess was achieved using a Cu(II) salen complex based on (S,S)-cyclohexanediamine and salicylaldehyde at -20 degrees C. Bulky substituents in the ligand led to a decrease in both the enantioselectivity and chemical yield, with complete loss of stereoselectivity achieved with certain substituents at positions 3 and 5 of the phenyl ring.
Article
Chemistry, Multidisciplinary
Zhibin Guo, Daehyun Oh, Min Sagong, Jewon Yang, Geumwoo Lee, Hyeung-geun Park
Summary: An efficient method for synthesizing chiral malonates was established using enantioselective phase transfer catalysis. The a-alkylation reaction of 2,2-diphenylethyl tert-butyl a-methylmalonates with (S,S)-3,4,5-trifluorophenyl-NAS bromide as a phase-transfer catalyst successfully yielded corresponding a-methyl-a-alkylmalonates. These compounds are versatile chiral building blocks with a quaternary carbon center, obtained in high chemical yields (up to 99%) and excellent enantioselectivities (up to 98% ee). Selective hydrolysis of a,a-dialkylmalonates to the corresponding chiral malonic monoacids was achieved using basic (KOH/MeOH) and acidic conditions (TFA/CH2Cl2), demonstrating the practicality of the method.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Physical
Xin-Shen Liang, Rui-Dong Li, Wei Sun, Zhong Liu, Xiao-Chen Wang
Summary: Borane-mediated hydride abstraction has been shown to be a powerful tool for the C(sp(3))-H functionalization of amines, but its activity with ethers is still unknown. In this study, we discovered this activity in 2H-chromenes and established a catalytic C(sp(3))-H functionalization reaction using silyl ketene acetals as nucleophiles.
Article
Biochemistry & Molecular Biology
Patryk Niedbala, Maciej Majdecki, Piotr Grodek, Janusz Jurczak
Summary: This work describes the development of a highly optimized method for generating quaternary stereogenic centers in beta-keto esters. The method utilizes a phase-transfer alkylation reaction catalyzed by hybrid Cinchona catalysts, resulting in efficient generation of optically active products with excellent enantioselectivity using only 1 mol% catalyst.
Article
Chemistry, Multidisciplinary
Tommaso Fantoni, Sara Bernardoni, Alexia Mattellone, Giulia Martelli, Lucia Ferrazzano, Paolo Cantelmi, Dario Corbisiero, Alessandra Tolomelli, Walter Cabri, Federica Vacondio, Francesca Ferlenghi, Marco Mor, Antonio Ricci
Summary: The use of N-hydroxyethylpyrrolidone (HEP)/water/N,N,N',N'-tetramethyl guanidine (TMG) as solvent/base mixture and sulfonated phosphine ligands in the Heck-Cassar and Sonogashira protocols allows for high yields and fast conversion under mild conditions, with the catalyst being recyclable without leakage or metal contamination.
Review
Thermodynamics
Joshua Iseoluwa Orege, Olayinka Oderinde, Ghebretensae Aron Kifle, Adeola Ahmed Ibikunle, Saheed Abiola Raheem, Onome Ejeromedoghene, Emmanuel Sunday Okeke, Olubunmi Michael Olukowi, Odunola Blessing Orege, Emmanuel Oluwaseyi Fagbohun, Taiwo Oladapo Ogundipe, Esther Praise Avor, Omoyemi Oluwatosin Ajayi, Michael Olawale Daramola
Summary: Heterogeneous catalysis provides a viable alternative for low-cost biodiesel production, and catalytic transesterification is considered the most feasible synthesis method. Nine commonly used heterogeneous catalysts have been studied, with a focus on versatile catalysts with high activity and low production cost.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Chemistry, Analytical
Ahmed Habib, Mokhtar M. Mabrouk, Marwa Fekry, Fotouh R. Mansour
Summary: Introducing glycerol as a green solvent in liquid chromatography can improve analyte transfer, optimize retention process, and enhance column efficiency. By optimizing conditions, the glycerol-containing mobile phase was successfully applied for separation of a mixture of four antiviral drugs, achieving acceptable resolution and peak shapes.
MICROCHEMICAL JOURNAL
(2021)
Article
Polymer Science
Roy Wink, Soumabrata Majumdar, Rolf A. T. M. van Benthem, Johan P. A. Heuts, Rint P. Sijbesma
Summary: Neighboring group assisted rearrangement increases relaxation rates in dynamic covalent networks for easier (re)processing. The introduction of anionic phosphate diesters as the sole dynamic group and β-hydroxy groups as a neighboring group mimics the self-cleaving backbone structure of RNA. The diester-based networks show slower dynamics but better hydrolytic and thermal stability compared to phosphate triester-based networks.
