期刊
CHEMCATCHEM
卷 4, 期 7, 页码 1007-1012出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201200124
关键词
asymmetric synthesis; Michael addition; nitroenamines; organocatalysis; oseltamivir
资金
- European Commission [FP7-201431(CATAFLU.OR)]
- Guangdong Recruitment Program of Creative Research Groups
Nitroenamine derivatives were used as a new class of Michael acceptors in the organocatalytic Michael reaction of aldehydes. The addition products were obtained in good yields and very good to excellent enantioselectivities. Moreover, a highly efficient, enantioselective, and simple synthesis of (-)-oseltamivir was accomplished in only five steps: two separate one-pot operations and one purification step. This procedural simplicity demonstrated the power of the organocatalytic asymmetric Michael reaction of nitroenamine acceptors with aldehydes.
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