Enhancement of Stability and Activity of siRNA by Terminal Substitution with Serinol Nucleic Acid (SNA)

Exploring Directional Invasion of Serum Nuclease into siRNA Duplexes by Asymmetrical Terminal Modifications

(2014) Ye Huang et al.   ChemMedChem

Highly Potent and Stable Capped siRNAs with Picomolar Activity for RNA Interference

(2013) Lv Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of Conformational Alteration Induced by d-/l-Isonucleoside Incorporation in siRNA on Their Stability in Serum and Silencing Activity

(2013) Ye Huang et al.   BIOCONJUGATE CHEMISTRY

Highly Stable Duplex Formation by Artificial Nucleic Acids Acyclic Threoninol Nucleic Acid (aTNA) and Serinol Nucleic Acid (SNA) with Acyclic Scaffolds

(2013) Keiji Murayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective labeling of mature RISC using a siRNA carrying fluorophore–quencher pair

(2013) Yukiko Kamiya et al.   Chemical Science

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity

(2012) Takanori Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Modification of the siRNA Passenger Strand by 5-Nitroindole Dramatically Reduces its Off-Target Effects

(2012) Junbin Zhang et al.   CHEMBIOCHEM

Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

(2012) Mayumi Takahashi et al.   NUCLEIC ACIDS RESEARCH

Efficacy of a Novel Class of RNA Interference Therapeutic Agents

(2012) Tomohiro Hamasaki et al.   PLoS One

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Control of the Chirality and Helicity of Oligomers of Serinol Nucleic Acid (SNA) by Sequence Design

(2011) Hiromu Kashida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Structure, and Biological Activity of Dumbbell-Shaped Nanocircular RNAs for RNA Interference

(2011) Naoko Abe et al.   BIOCONJUGATE CHEMISTRY

Improvement of RNAi Activity and Strand Selectivity of RISC Formation by Modified siRNA Involving Intercalators near 5′ Termini

(2011) Hiroshi Ito et al.   CHEMBIOCHEM

Silencing activity of 2′-O-methyl modified anti-MDR1 siRNAs with mismatches in the central part of the duplexes

(2011) Natalya S. Petrova et al.   FEBS LETTERS

Improved siRNA/shRNA Functionality by Mismatched Duplex

(2011) Haoquan Wu et al.   PLoS One

Incorporation of Biaryl Units into the 5′ and 3′ Ends of Sense and Antisense Strands of siRNA Duplexes Improves Strand Selectivity and Nuclease Resistance

(2010) Kayo Yoshikawa et al.   BIOCONJUGATE CHEMISTRY

RNA interference with 2′,4′-bridged nucleic acid analogues

(2010) S.M. Abdur Rahman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

(2010) Maria B. Laursen et al.   Molecular BioSystems

Modulation of thermal stability can enhance the potency of siRNA

(2010) H. Addepalli et al.   NUCLEIC ACIDS RESEARCH

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

(2010) Narendra Vaish et al.   NUCLEIC ACIDS RESEARCH

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

(2008) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY