Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

On-target Inhibition of Tumor Fermentative Glycolysis as Visualized by Hyperpolarized Pyruvate

(2015) Pankaj Seth et al.   NEOPLASIA

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

(2013) Benjamin P. Fauber et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

(2013) Peter S. Dragovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors

(2013) P. Dutta et al.   CANCER RESEARCH

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors

(2013) Anna Kohlmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

(2013) Carlotta Granchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glucose conjugation for the specific targeting and treatment of cancer

(2013) Emilia C. Calvaresi et al.   Chemical Science

Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs

(2012) Valentina Oliveri et al.   DALTON TRANSACTIONS

Design, Synthesis, and Preliminary Biological Evaluation of 6-O-Glucose–Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors

(2012) Piyush Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

(2012) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhancement of Cyclopamine via Conjugation with Nonmetabolic Sugars

(2012) Randal D. Goff et al.   ORGANIC LETTERS

New aspects of the Warburg effect in cancer cell biology

(2012) Steven J. Bensinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications

(2012) Woong Hee Kim et al.   SENSORS

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

(2011) Natalie E. Simpson et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma

(2011) Long Huang et al.   CANCER

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Development of Fluorescent Glucose Bioprobes and Their Application on Real-Time and Quantitative Monitoring of Glucose Uptake in Living Cells

(2011) Hyang Yeon Lee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity

(2011) Pauline Peltier-Pain et al.   ChemMedChem

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

Targeting cancer metabolism – aiming at a tumour's sweet-spot

(2011) Neil P. Jones et al.   DRUG DISCOVERY TODAY

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo

(2011) Christian D. Young et al.   PLoS One

Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

(2010) C. Granchi et al.   CURRENT MEDICINAL CHEMISTRY

Assessment of Chemoselective Neoglycosylation Methods Using Chlorambucil as a Model

(2010) Randal D. Goff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

(2010) Luigi Fiume et al.   PHARMACOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomised Phase III trial of glufosfamide compared with best supportive care in metastatic pancreatic adenocarcinoma previously treated with gemcitabine

(2009) Tudor E. Ciuleanu et al.   EUROPEAN JOURNAL OF CANCER

Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis

(2008) Yanislav Kolev et al.   ANNALS OF SURGICAL ONCOLOGY

Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters

(2008) Yih-Shyan Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY