Development of a Reduction-Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Drug Discovery for Targeting the Tumor Microenvironment

(2011) Hideko Nagasawa   JOURNAL OF PHARMACOLOGICAL SCIENCES

Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O–N acyl transfer

(2011) Akira Shigenaga et al.   TETRAHEDRON

Enantioselective synthesis of stimulus-responsive amino acid via asymmetric α-amination of aldehyde

(2010) Akira Shigenaga et al.   TETRAHEDRON

Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide

(2010) Akira Shigenaga et al.   TETRAHEDRON LETTERS

Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system

(2010) Akira Shigenaga et al.   TETRAHEDRON LETTERS

The HIF-1-active microenvironment: An environmental target for cancer therapy

(2009) Shinae Kizaka-Kondoh et al.   ADVANCED DRUG DELIVERY REVIEWS

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

(2009) Eiji Nakata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides: influence of amino acid sequence on reaction kinetics

(2009) Akira Shigenaga et al.   TETRAHEDRON

Design of anticancer prodrugs for reductive activation

(2008) Yu Chen et al.   MEDICINAL RESEARCH REVIEWS

Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

(2007) Ikuhiko Nakase et al.   ADVANCED DRUG DELIVERY REVIEWS