Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms

Enantiomeric Natural Products: Occurrence and Biogenesis

(2012) Jennifer M. Finefield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of Two Bacterial Hydroxynitrile Lyases with High Similarity to Cupin Superfamily Proteins

(2012) Zahid Hussain et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tailoring a Stabilized Variant of Hydroxynitrile Lyase from Arabidopsis thaliana

(2012) Daniel Okrob et al.   CHEMBIOCHEM

Hydroxynitrile Lyase from Arabidopsis thaliana: Identification of Reaction Parameters for Enantiopure Cyanohydrin Synthesis by Pure and Immobilized Catalyst

(2011) Daniel Okrob et al.   ADVANCED SYNTHESIS & CATALYSIS

Directed Evolution Strategies for Enantiocomplementary Haloalkane Dehalogenases: From Chemical Waste to Enantiopure Building Blocks

(2011) Jan G. E. van Leeuwen et al.   CHEMBIOCHEM

Synthesis of (R)-β-nitro alcohols catalyzed by R-selective hydroxynitrile lyase from Arabidopsis thaliana in the aqueous–organic biphasic system

(2011) Ken-ichi Fuhshuku et al.   JOURNAL OF BIOTECHNOLOGY

S-selective hydroxynitrile lyase from a plant Baliospermum montanum: Molecular characterization of recombinant enzyme

(2011) Mohammad Dadashipour et al.   JOURNAL OF BIOTECHNOLOGY

Stereocomplementary asymmetric bioreduction of boron-containing ketones mediated by alcohol dehydrogenases

(2011) Thiago Barcellos et al.   TETRAHEDRON-ASYMMETRY

Hydroxynitrile Lyases: Insights into Biochemistry, Discovery, and Engineering

(2011) Mohammad Dadashipour et al.   ACS Catalysis

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Basis for Enantioselectivity in the (R)- and (S)-Hydroxypropylthioethanesulfonate Dehydrogenases, a Unique Pair of Stereoselective Short-Chain Dehydrogenases/Reductases Involved in Aliphatic Epoxide Carboxylation

(2010) Dariusz A. Sliwa et al.   BIOCHEMISTRY

Switching from an Esterase to a Hydroxynitrile Lyase Mechanism Requires Only Two Amino Acid Substitutions

(2010) Santosh Kumar Padhi et al.   CHEMISTRY & BIOLOGY

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity†,‡

(2009) Ingrid Dreveny et al.   BIOCHEMISTRY

Uneven twins: Comparison of two enantiocomplementary hydroxynitrile lyases with α/β-hydrolase fold

(2009) Jan-Karl Guterl et al.   JOURNAL OF BIOTECHNOLOGY

How to overcome limitations in biotechnological processes - examples from hydroxynitrile lyase applications

(2009) J.N. Andexer et al.   TRENDS IN BIOTECHNOLOGY

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

(2008) Paul F. Mugford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Complete Inversion of Enantioselectivity towards Acetylated Tertiary Alcohols by a Double Mutant of aBacillus Subtilis Esterase

(2008) Sebastian Bartsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The active site of hydroxynitrile lyase from Prunus amygdalus: Modeling studies provide new insights into the mechanism of cyanogenesis

(2002) Ingrid Dreveny et al.   PROTEIN SCIENCE