Generation of Novel Nucleases with Extended Specificity by Rational and Combinatorial Strategies

Photocaged Variants of the MunI and PvuII Restriction Enzymes

(2011) Arunas Silanskas et al.   BIOCHEMISTRY

Zinc-Finger Nucleases: A Panoramic View

(2011) Dana Carroll   CURRENT GENE THERAPY

Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

(2011) George Silva et al.   CURRENT GENE THERAPY

Zinc-Finger Nuclease Based Genome Surgery: Its All About Specificity

(2011) Eva-Maria Handel et al.   CURRENT GENE THERAPY

TAL effectors are remote controls for gene activation

(2011) Heidi Scholze et al.   CURRENT OPINION IN MICROBIOLOGY

Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells

(2011) Stéphanie Grosse et al.   MOLECULAR THERAPY

TALEs of genome targeting

(2011) Jens Boch   NATURE BIOTECHNOLOGY

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

TALEs for the masses

(2011) Nicole Rusk   NATURE METHODS

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

(2011) M. M. Mahfouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

(2011) Barry L. Stoddard   STRUCTURE

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Targeting of an Interrupted Polypurine:Polypyrimidine Sequence in Mammalian Cells by a Triplex-Forming Oligonucleotide Containing a Novel Base Analogue

(2010) A. Semenyuk et al.   BIOCHEMISTRY

The down regulation of target genes by photo activated DNA nanoscissors

(2010) Tsung-Lin Tsai et al.   BIOMATERIALS

Targeted Gene Repair Facilitated by Peptide Nucleic Acids (PNA)

(2010) Peter E. Nielsen    CHEMBIOCHEM

TAL effectors: finding plant genes for disease and defense

(2010) Adam J Bogdanove et al.   CURRENT OPINION IN PLANT BIOLOGY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity

(2010) Rakesh Joshi et al.   JOURNAL OF MOLECULAR BIOLOGY

Creating Designed Zinc-Finger Nucleases with Minimal Cytotoxicity

(2010) Sivaprakash Ramalingam et al.   JOURNAL OF MOLECULAR BIOLOGY

Zinc-finger Nuclease-induced Gene Repair With Oligodeoxynucleotides: Wanted and Unwanted Target Locus Modifications

(2010) Sarah Radecke et al.   MOLECULAR THERAPY

Targeted integration in rat and mouse embryos with zinc-finger nucleases

(2010) Xiaoxia Cui et al.   NATURE BIOTECHNOLOGY

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

(2010) Jeffry D Sander et al.   NATURE METHODS

Genome editing with modularly assembled zinc-finger nucleases

(2010) Jin-Soo Kim et al.   NATURE METHODS

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

(2010) Yannick Doyon et al.   NATURE METHODS

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

(2010) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

(2010) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

(2010) R. Morbitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

(2010) S. Arnould et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The repeat domain of the type III effector protein PthA shows a TPR-like structure and undergoes conformational changes upon DNA interaction

(2010) Mário Tyago Murakami et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genome editing in plant cells by zinc finger nucleases

(2010) Dan Weinthal et al.   TRENDS IN PLANT SCIENCE

TAL effector-DNA specificity

(2010) Heidi Scholze et al.   Virulence

Homing endonucleases: from basics to therapeutic applications

(2009) Maria J. Marcaida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Rational engineering of type II restriction endonuclease DNA binding and cleavage specificity

(2009) Richard D. Morgan et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

REBASE—a database for DNA restriction and modification: enzymes, genes and genomes

(2009) Richard J. Roberts et al.   NUCLEIC ACIDS RESEARCH

Controlling the enzymatic activity of a restriction enzyme by light

(2009) B. Schierling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Zinc finger nuclease technology heralds a new era in mammalian transgenesis

(2009) Fabienne Le Provost et al.   TRENDS IN BIOTECHNOLOGY

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

(2008) Morgan L. Maeder et al.   MOLECULAR CELL

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

(2008) Pilar Redondo et al.   NATURE

Unexpected failure rates for modular assembly of engineered zinc fingers

(2008) Cherie L Ramirez et al.   NATURE METHODS

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

(2008) Emmanuel Fajardo-Sanchez et al.   NUCLEIC ACIDS RESEARCH

The triple helix: 50 years later, the outcome

(2008) M. Duca et al.   NUCLEIC ACIDS RESEARCH

DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases

(2007) Tatjana I Cornu et al.   MOLECULAR THERAPY