期刊
CHEMBIOCHEM
卷 12, 期 2, 页码 281-289出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201000434
关键词
amino acids; biocatalysis; cofactors; deacetylation; enzyme catalysis
资金
- NIGMS NIH HHS [R01 GM065386, R01 GM065386-08] Funding Source: Medline
SIRT1 is a member of the Sir2 family of NAD(+)-dependent protein deacetylases. The central role of SIRT1 in multiple metabolic and age-related pathways has pushed SIRT1 to the forefront to discover small-molecule activators. Promising compounds, including resveratrol and SRT1720 have been reported, however, whether these compounds are direct activators and the mechanism by which they activate remains poorly defined. This review examines the current debate surrounding purported activators, and will focus on the assays used in screening compounds, sirtuin catalysis, and the mechanistic basis for their actions. We discuss the potential pathways of SIRT1 activation that could be exploited for the development of novel therapeutics for treating type II diabetes, neurodegeneration, and diseases associated with aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据