Review
Cell Biology
Bethan A. Cole, Esther B. E. Becker
Summary: The TRPC3 channel is a crucial player in calcium signaling and is regulated by various endogenous and exogenous factors. Recent studies have advanced our understanding of the regulatory mechanisms of TRPC3, which has implications for the development of therapeutic interventions for diseases associated with this channel.
Article
Pharmacology & Pharmacy
Martin Kruse, Rayne J. Whitten
Summary: Phosphoinositides, despite being a minor component of cell lipids, play essential roles in regulating neuronal activities. Activation of neurotransmitter receptors can rapidly deplete phosphoinositide levels, significantly impacting neuronal behavior. A comprehensive model has been developed to study the connection between muscarinic acetylcholine signaling, phosphoinositide metabolism, and action potential firing in sympathetic neurons.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Summary: The E7K mutation in the TRPM4 channel enhances channel function by altering its interaction with endogenous PIP2, potentially contributing to its arrhythmogenic potential.
Article
Neurosciences
Wenjun Guo, Qinglin Tang, Miao Wei, Yunlu Kang, Jing-Xiang Wu, Lei Chen
Summary: In this study, the cryo-EM structures of TRPC3 and TRPC6 channels were determined, revealing the calcium-dependent regulation and the pathogenic mechanism of GOF mutations associated with diseases like FSGS. These findings provide important insights for further research and structure-based drug design.
Article
Biochemistry & Molecular Biology
Tarek Mohamed Abd El-Aziz, Amanpreet Kaur, Mark S. Shapiro, James D. Stockand, Crystal R. Archer
Summary: The activity of ENaC is strongly dependent on PIP2, and the beta N1 and gamma N2 binding sites on ENaC are crucial for its sensitivity to changes in PIP2 levels. Mutations in these binding sites inhibit ENaC's response to PIP2 depletion and recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Elena O. Gracheva, Sviatoslav N. Bagriantsev
Summary: David Julius and Ardem Patapoutian were awarded this year's Nobel Prize in Physiology or Medicine for explaining the molecular basis for sensing heat, cold and mechanical force, marking the end of a scientific journey to identify the mechanisms in the somatosensory system mediating the detection of internal and external environments.
Review
Cell Biology
Giorgia Chinigo, Helene Castel, Oana Chever, Dimitra Gkika
Summary: Malignant glioma, especially glioblastoma (GBM), is a common primary brain tumor with high resistance to standard treatment. Recent studies have identified TRP channels as potential new molecular targets for glioma treatment, offering directions for innovative strategies to overcome high resistance and recurrence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Maglie, Daniel Souza Monteiro de Araujo, Emiliano Antiga, Pierangelo Geppetti, Romina Nassini, Francesco De Logu
Summary: TRPA1, a member of the TRP superfamily, plays a crucial role in sensory neurons and has been found to be expressed in various skin cells, contributing to skin physiology and pathophysiology. Recent studies have highlighted the potential use of TRPA1 antagonists in the treatment of inflammatory and immunological skin disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Michihiro Tateyama, Yoshihiro Kubo
Summary: THIK-1 and THIK-2 channels can be activated by Gi/o-Rs and Gq-Rs, respectively, in a G beta gamma-dependent and PLC-dependent manner. Additionally, heterodimeric channels of THIK-1 and THIK-2 also respond to Gi/o-R and Gq-R stimulation.
Article
Biochemistry & Molecular Biology
Peng-fei Tian, Meng-meng Sun, Xian-yu Hu, Juan Du, Wei He
Summary: TRPP2 is a nonselective cation channel that functions in endoplasmic reticulum, plasma membrane, and primary cilia. It is involved in regulating calcium release, intracellular ion concentration, mechanosensitivity, and diseases such as polycystic kidney disease.
Review
Biochemistry & Molecular Biology
Gang-Fan Zong, Rui Deng, Su-Yun Yu, Ai-Yun Wang, Zhong-Hong Wei, Yang Zhao, Yin Lu
Summary: This paper summarizes the existing literature on the changes in thermo-TRP protein expression that are associated with the incidence and progression of gastric cancer (GC). The elucidation of the mechanisms underlying the response of thermo-TRPs to physiological stimuli or drugs is crucial for advancements in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loic Lemonnier, Natalia Prevarskaya
Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Zixuan Yuan, Scott B. B. Hansen
Summary: Cholesterol and PIP2 are hydrophobic molecules that regulate protein function in the plasma membrane. This review discusses how changes in cholesterol concentration and the independent function of PIP2 affect nanoscopic protein movement. Super-resolution imaging and two-color techniques have contributed to our understanding of protein movement between lipid domains. Labeling techniques for imaging, their applications, and novel mechanisms for enzyme function are also discussed. The role of PIP2 in opposing cholesterol regulation is explored through super-resolution imaging.
Review
Biochemistry & Molecular Biology
Yaxian Zhao, Bridget M. McVeigh, Vera Y. Moiseenkova-Bell
Summary: TRP ion channels are a super-family that mediate transmembrane cation flux in response to various stimuli. Recognized as potential pharmacological targets due to their role in human diseases, advances in cryo-EM TRP channel structural biology have shown diverse architectural elements and regulatory sites. This review focuses on the ligand-binding sites and regulatory mechanisms of TRP channels.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bingxue Li, Songling Li, Honglan Zheng, Zhiqiang Yan
Summary: Research shows that in Drosophila larvae, the MET currents in Cho neurons are mediated by two TRPV channels, NAN and IAV, with the C-terminal residues 857 through 990 of IAV regulating the kinetics of MET currents. Additionally, the NompC channel contributes to the adaptation of auditory transduction currents.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)