期刊
CHANNELS
卷 3, 期 2, 页码 77-81出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.3.2.8037
关键词
alcoholism; N-type calcium channel; place preference; NP078585; addiction; therapeutics
资金
- NIAAA NIH HHS [R01 AA013588] Funding Source: Medline
We recently validated the N-type calcium channel as a target for the treatment of alcoholism and anxiety. N-type calcium channels are neuronal presynaptic ion channels that regulate neurotransmitter release at many sites in the brain. Mice lacking N-type calcium channels exhibit reduced ethanol consumption and show resistance to the acute intoxicating effects of ethanol. In wild type rodents, pretreatment with a novel N- and T-type calcium channel blocker, NP078585, reduces the intoxicating and reinforcing effects of ethanol and abolishes stress-induced reinstatement of alcohol seeking. Here we discuss these findings and expand upon their implications for the N-type calcium channel as a target for drug development. An important consideration in the development of drugs to treat any addiction is that the medication itself not be addictive. We attempted, and failed, to generate a conditioned place preference for NP078585, suggesting that NP078585 is not rewarding.
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