Article
Clinical Neurology
Tan Li, Mengfan Ye, Guopeng Yang, Shanshan Diao, Yun Zhou, Yiren Qin, Dongxue Ding, Mo Zhu, Qi Fang
Summary: WMH, especially frontal WMH volume and the presence of WMH at the GCC at baseline, independently contributed to long-term cognitive decline in ALS patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Anna K. Bonkhoff, Sungmin Hong, Martin Bretzner, Markus D. Schirmer, Robert W. Regenhardt, E. Murat Arsava, Kathleen Donahue, Marco Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa McIntosh, John Attia, Oscar Benavente, John W. Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven Kittner, Robin Lemmens, Christopher Levi, Caitrin W. McDonough, James Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Martin Soederholm, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Polina Golland, Danilo Bzdok, Ona Wu, Natalia S. Rost
Summary: This study examines the association between high white matter hyperintensity (WMH) burden and stroke severity and functional outcomes. The findings suggest that higher WMH burden may be associated with increased stroke severity and worse functional outcomes.
Article
Biology
Wenjun Xu, Xing Guo, Yifeng Du
Summary: Cerebral white matter lesions (WML) and lacunar infarctions (LI) are major causes of cognitive deficits. A study on elderly individuals with WML aimed to investigate the correlation between LI and cognitive deficits. The study found that the presence of LI in WML patients is associated with further aggravation of cognitive deficits.
OPEN LIFE SCIENCES
(2022)
Article
Clinical Neurology
Maria del C. Valdes Hernandez, Tara Grimsley-Moore, Eleni Sakka, Michael J. Thrippleton, Francesca M. Chappell, Paul A. Armitage, Stephen Makin, Joanna M. Wardlaw
Summary: Research has shown a correlation between the volume of white matter hyperintensities and the number of lacunes in patients with lacunar strokes, while the location of recent small subcortical infarcts may affect the spatial distribution and evolution of the white matter hyperintensities. Vascular risk factors such as hypertension and smoking could further influence the relationship between these different brain lesions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Kira Kornienko, Miriam Reuter, Andreas Maxeiner, Karsten Gunzel, Beatrice Kittner, Maximilian Reimann, Sebastian L. Hofbauer, Laura E. Wiemer, Robin Heckmann, Patrick Asbach, Johann Jakob Wendler, Martin Schostak, Thorsten Schlomm, Frank Friedersdorff, Hannes Cash
Summary: This study evaluates the management and rate of clinically significant Prostate Cancer (csPCa) in patients with a Prostate Imaging-Reporting and Data System (PI-RADS) >= 4 lesion and a negative biopsy. The results suggest that men with a positive mpMRI and lesions with high suspicion should be considered for repeat biopsy or strict surveillance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mohammed Y. Ezzeldin, Doaa M. Mahmoud, Shady M. Safwat, Radwa Kamel Soliman, Tarek Desoky, Eman M. Khedr
Summary: Fatigue is a common symptom in RRMS, and gray matter atrophy has been linked to fatigue in previous studies. However, the relationship between fatigue and white matter lesion load (WM-LL) has received less attention. This study aims to assess this relationship.
SCIENTIFIC REPORTS
(2023)
Article
Neuroimaging
Sara Leddy, Laura Serra, Davide Esposito, Camilla Vizzotto, Giovanni Giulietti, Gabriella Silvestri, Antonio Petrucci, Giovanni Meola, Leonardo Lopiano, Mara Cercignani, Marco Bozzali
Summary: Patients with Myotonic Dystrophy type 1 exhibit widespread white matter lesions associated with CTG triplet expansion, with a higher prevalence of anterior temporal lobe lesions compared to patients with multiple sclerosis (MS). While the lesion volume is smaller in DM1 compared to MS, DM1 lesions show a significant loss of myelin density, which is not observed in the normal appearing white matter.
NEUROIMAGE-CLINICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Troy Storey, Roberto Ezequiel Borgia, Parker Merritt, Leandra Woolnough
Summary: The distribution of increased T2 signal intensity within the sacral marrow adjacent to the sacroiliac joints in healthy children and adolescents is characterized, and this normal pattern is beneficial in interpreting MRI examinations for the presence of sacroiliitis.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2022)
Article
Multidisciplinary Sciences
Garazi Labayru, Borja Camino, Antonio Jimenez-Marin, Joana Garmendia, Jorge Villanua, Miren Zulaica, Jesus M. Cortes, Adolfo Lopez de Munain, Andone Sistiaga
Summary: DM1 patients exhibit significant loss of WM integrity over time, with progressive anterior-posterior disconnection.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Danielle Kerkhofs, Sau May Wong, Eleana Zhang, Renske Uiterwijk, Erik I. Hoff, Jacobus F. A. Jansen, Julie Staals, Walter H. Backes, Robert J. van Oostenbrugge
Summary: Blood-brain barrier dysfunction is a key factor in cerebral small vessel disease. Higher BBB leakage at baseline is associated with stronger cognitive decline, specifically in executive function, over 2 years in patients with cSVD. This highlights the important role of BBB disruption in the pathophysiology and clinical progression of cSVD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jannis Muller, Francesco La Rosa, Jeremy Beaumont, Charidimos Tsagkas, Reza Rahmanzadeh, Matthias Weigel, Meritxell Bach Cuadra, Giulio Gambarota, Cristina Granziera
Summary: The manual detection rate of cortical lesions on MP2RAGE(uni), FLAWS(min), and FLAWS(hco) in MS patients is comparable. The combination of FLAWS(min) and FLAWS(hco) allows for the identification of more cortical lesions. There is no difference in quantitative T1 maps (qT1) provided by MP2RAGE and FLAWS.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Obstetrics & Gynecology
Masae Kobayashi, Shimpei Watanabe, Tadashi Matsuda, Hideyuki Ikeda, Tatsuro Nawa, Shinichi Sato, Haruo Usuda, Takushi Hanita, Yoshiyasu Kobayashi
Summary: This study demonstrates that MRI can visualize necrotic foci of periventricular leukomalacia (PVL) as punctate white matter lesions (PWML) in a sheep fetus model. The diagnostic sensitivity and positive predictive values of histologic focal necrosis visualized as PWML were high, suggesting the potential of using MRI for accurate diagnosis of mild PVL in the acute phase.
REPRODUCTIVE SCIENCES
(2021)
Article
Infectious Diseases
Monira Ali Dakheel, Abdelrahman Mohamed Najaim, Ahmed Mesbah Moslah, Halima Daw Buni
Summary: This case demonstrates the possibility of early disseminated tuberculosis in infants and highlights the challenges of early diagnosis. Early diagnosis and treatment are crucial in preventing severe consequences in infants.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Gastroenterology & Hepatology
Janusiya Anajan Muthulingam, Soren Schou Olesen, Tine Maria Hansen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: This study aimed to explore cerebral white matter changes in individuals with chronic pancreatitis (CP) at baseline and after 7 years compared to controls, as well as their associations with risk factors and clinical parameters. The results showed widespread reductions in fractional anisotropy (FA) in CP patients at baseline, which can be attributed to the CP disease and exposure to toxic substances. However, the progression of white matter changes in CP patients resembles that in healthy controls.
Article
Computer Science, Information Systems
Adriano Pinto, Joana Amorim, Arsany Hakim, Victor Alves, Mauricio Reyes, Carlos A. Silva
Summary: Stroke is the second most common cause of death in developed countries, and rapid clinical assessment and intervention play a crucial role in improving patients' quality of life. Clinical interventions aim to restore perfusion deficits, and a deep learning method can automatically predict ischemic stroke tissue outcome.