☆ 4.6 Article Proceedings Paper

The Effects of Continuous Positive Airway Pressure on Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Surgery: A Systematic Review and Meta-Analysis

ANESTHESIA AND ANALGESIA (2015)

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ANESTHESIA AND ANALGESIA

卷 120, 期 5, 页码 1013-1023

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LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1213/ANE.0000000000000634

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Anesthesiology

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Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto

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BACKGROUND: Obstructive sleep apnea (OSA) is a commonly encountered comorbid condition in patients undergoing surgery and is associated with a greater risk of postoperative adverse events. Our objective in this review was to investigate the effectiveness of continuous positive airway pressure (CPAP) in reducing the risk of postoperative adverse events in patients with OSA undergoing surgery, the perioperative Apnea-Hypopnea Index (AHI), and the hospital length of stay (LOS). METHODS: We performed a systematic search of the literature databases. We reviewed the studies that included the following: (1) adult surgical patients (>18 years old) with information available on OSA; (2) patients using either preoperative and/or postoperative CPAP or no-CPAP; (3) available reports on postoperative adverse events, preoperative and postoperative AHI, and LOS; and (4) all published studies in English including case series. RESULTS: Six studies that included 904 patients were eligible for the meta-analysis. The meta-analysis for postoperative adverse events was performed in 904 patients (CPAP: n = 471 vs no-CPAP: n = 433; adverse events: 134 vs 133; P = 0.19). There was no significant difference in the postoperative adverse events between the 2 groups. The preoperative baseline AHI without CPAP was reduced significantly with postoperative use of CPAP (preoperative AHI versus postoperative AHI, 37 +/- 19 vs 12 +/- 16 events per hour, P < 0.001). LOS showed a trend toward significance in the CPAP group versus the no-CPAP group (4.0 +/- 4 vs 4.4 +/- 8 days, P = 0.05). CONCLUSIONS: Our review suggests that there was no significant difference in the postoperative adverse events between CPAP and no-CPAP treatment. Patients using CPAP had significantly lower postoperative AHI and a trend toward shorter LOS. There may be potential benefits in the use of CPAP during the perioperative period.

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Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea: A Meta-Analysis

Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li

Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.

JOURNAL OF CLINICAL MEDICINE (2022)