Article
Endocrinology & Metabolism
Joel S. Burma, Rowan K. Van Roessel, Ibukunoluwa K. Oni, Jeff F. Dunn, Jonathan D. Smirl
Summary: When quantifying neurovascular coupling (NVC) with transcranial Doppler ultrasound (TCD), completing a minimum of five trials is necessary to ensure the validity and reliability of NVC metrics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biology
Kyle W. W. Gheres, Hayreddin S. S. Unsal, Xu Han, Qingguang Zhang, Kevin L. L. Turner, Nanyin Zhang, Patrick J. J. Drew
Summary: This study found that sensory stimulation in neonatal mice induces a small increase in blood volume, followed by a large decrease. The arousal state of the mice, especially sleep, plays a dominant role in regulating neurovascular coupling, obscuring the sensory-evoked changes. The findings highlight the importance of considering sleep-related vascular changes in hemodynamic measures.
COMMUNICATIONS BIOLOGY
(2023)
Article
Behavioral Sciences
Ana Ovsenik, Matej Podbregar, Nikola Lakic, Martin Bresar, Pavle Boskoski, Ivan Verdenik, Andrej Fabjan
Summary: This study aims to evaluate neurovascular coupling in patients with aortic stenosis (AS) using Transcranial Doppler ultrasonography. The results show that patients with AS have higher relative blood flow velocity changes, indicating dysregulation of neurovascular coupling, which could be a contributing factor to cognitive decline.
BRAIN AND BEHAVIOR
(2023)
Article
Endocrinology & Metabolism
Jodie L. Koep, Bert Bond, Alan R. Barker, Stefanie L. Ruediger, Faith K. Pizzey, Jeff S. Coombes, Tom G. Bailey
Summary: This study aimed to investigate the effects of age and sex on neurovascular coupling (NVC). The results showed a negative relationship between NVC and age in females, while no relationship was found in males. These findings highlight the importance of considering sex-dependent effects of aging when studying cerebrovascular regulation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biology
Mitsuhiro Fukuda, Alexander J. Poplawsky, Seong-Gi Kim
Summary: High-resolution functional magnetic resonance imaging (fMRI) is gaining popularity due to the availability of ultra-high magnetic fields, but the accuracy of detecting the true location of neuronal activity using increased spatial resolutions remains debatable.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biology
Pratish Thakore, Michael G. Alvarado, Sher Ali, Amreen Mughal, Paulo W. Pires, Evan Yamasaki, Harry A. T. Pritchard, Brant E. Isakson, Cam Ha T. Tran, Scott Earley
Summary: Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the brain's metabolic demands. TRPA1 channels in capillary endothelial cells act as neural activity sensors, initiating microvascular vasodilatory responses to redirect blood flow to regions of metabolic demand.
Article
Endocrinology & Metabolism
Amy R. Nippert, Pei-Pei Chiang, Eric A. Newman
Summary: Hypoglycemia is a serious complication of insulin treatment in diabetes. Previous studies suggested that neurovascular coupling, which increases glucose availability to active neurons, might be reduced during hypoglycemia. However, this study found that neurovascular coupling did not change significantly during hypoglycemia and that there was an increase in vessel diameter, suggesting active mechanisms to maintain glucose supply to the brain during hypoglycemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Physiology
Jack K. Leacy, Emily M. Johnson, Lauren R. Lavoie, Diane N. Macilwraith, Megan Bambury, Jason A. Martin, Eric F. Lucking, Andrea M. Linares, Gurkarn Saran, Dwayne P. Sheehan, Nishan Sharma, Trevor A. Day, Ken D. O'Halloran
Summary: The aim of this study was to determine the relative and combined contribution of age and sex to the variation observed across several distinct NVC metrics. The results suggest that variability in NVC response magnitude is independent of age and sex in healthy human participants.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Neurosciences
Patrick J. Drew
Summary: In the brain, increases in neural activity lead to changes in local blood flow through neurovascular coupling. However, the traditional explanation that increased blood flow supplies the metabolic needs of active neurons is inconsistent with a large body of evidence. Neurovascular coupling is irregular or absent in many brain regions and states, and increased respiration can improve brain oxygenation without changes in blood flow. Simulation studies suggest that low blood flow areas are inevitable due to the brain's vascular architecture and cannot be eliminated by functional hyperemia. This article discusses potential alternative functions of neurovascular coupling such as supplying oxygen for neuromodulator synthesis, regulating brain temperature, signaling to neurons, optimizing cerebral vascular structure, accommodating non-Newtonian blood flow, and driving cerebrospinal fluid circulation.
TRENDS IN NEUROSCIENCES
(2022)
Article
Physiology
Jack K. Leacy, Emily M. Johnson, Lauren R. Lavoie, Diane N. Macilwraith, Megan Bambury, Jason A. Martin, Eric F. Lucking, Andrea M. Linares, Gurkarn Saran, Dwayne P. Sheehan, Nishan Sharma, Trevor A. Day, Ken D. O 'Halloran
Summary: The study found that the variability in neurovascular coupling response magnitude is independent of age and sex in healthy human participants aged 21-66 years old. The differences observed in NVC response are likely due to other physiological factors rather than age or sex.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Neurosciences
Xiaoshuai Li, Ning Xu, Chihang Dai, Xuxu Meng, Xiaoyu Qiu, Heyu Ding, Rong Zeng, Han Lv, Pengfei Zhao, Zhenghan Yang, Shusheng Gong, Zhenchang Wang
Summary: This study found altered cerebral blood flow and regional homogeneity in pulsatile tinnitus patients, indicating abnormal neurovascular coupling in these patients. These findings provide new information for understanding the neuropathological mechanisms underlying pulsatile tinnitus.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Congping Chen, Zhentao She, Peng Tang, Zhongya Qin, Jufang He, Jianan Y. Qu
Summary: The study presented an approach for imaging neurovascular dynamics in live mouse cortices using multi-contrast mesoscopic and two-photon microscopic imaging, revealing the spatiotemporal correlation between neuronal and vascular responses. The research uncovered significant differences in NVC at regional and microvascular levels, as well as the impact of different brain states on NVC, particularly showing that anesthesia and sedation disrupt NVC.
Article
Neurosciences
Yi Yuan, Qianqian Wu, Xingran Wang, Mengyang Liu, Jiaqing Yan, Hui Ji
Summary: Previous studies have shown that transcranial ultrasound stimulation (TUS) can modulate cerebral hemodynamics, neural activity, and neurovascular coupling in resting samples, as well as inhibit neural activity in task samples. However, the effects of TUS on cerebral blood oxygenation and neurovascular coupling in task samples are still unclear.
Article
Cell Biology
Hanzhi T. Zhao, Mary Claire Tuohy, Daniel Chow, Mariel G. Kozberg, Sharon H. Kim, Mohammed A. Shaik, Elizabeth M. C. Hillman
Summary: Research has found that in acute brain injuries, CSD can cause vasoconstriction and ischemia, with its effects worsening with repeated CSD occurrences. This feedback loop may explain the variable but potentially devastating effects of CSD in the context of acute brain injury.
Article
Neurosciences
Ting Li, Tiantian Liu, Jian Zhang, Yunxiao Ma, Gongshu Wang, Dingjie Suo, Bowen Yang, Xiu Wang, Shintaro Funahashi, Kai Zhang, Boyan Fang, Tianyi Yan
Summary: This study found alterations in neurovascular coupling in patients with Parkinson's disease, affecting motor and nonmotor functions. Distinctive changes in neurovascular coupling were observed in the dorsal and ventral visual streams of the visual system.
NEUROBIOLOGY OF DISEASE
(2023)
