期刊
CEREBRAL CORTEX
卷 25, 期 9, 页码 3064-3076出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhu102
关键词
amygdala; marmoset; orbitofrontal cortex; probabilistic reversal learning
资金
- Wellcome Trust [089589/Z/09/Z]
- Medical Research Council (MRC) [G0901884]
- J.S. McDonnell Foundation [220020155]
- MRC
- Medical Research Council [G0901884, G0001354B, G1000183, G0001354, MR/J012084/1, G1000183B] Funding Source: researchfish
- MRC [MR/J012084/1, G0901884, G1000183] Funding Source: UKRI
Understanding the role of serotonin (or 5-hydroxytryptamine, 5-HT) in aversive processing has been hampered by the contradictory findings, across studies, of increased sensitivity to punishment in terms of subsequent response choice but decreased sensitivity to punishment- induced response suppression following gross depletion of central 5-HT. To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression. Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity. A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.
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