Article
Neurosciences
Chloe E. Meehan, Christine M. Embury, Alex Wiesman, Mikki Schantell, Sara L. Wolfson, Jennifer O'Neill, Susan Swindells, Craig M. Johnson, Pamela E. May, Daniel L. Murman, Tony W. Wilson
Summary: This study examines the neural dynamics underlying visuospatial processing in individuals with HIV-associated neurocognitive disorder (HAND) and Alzheimer's disease (AD). The results show both common and unique neurophysiological alterations among patients with HAND and ADS disorders in regions serving visuospatial processing.
Article
Neurosciences
Elizabeth Heinrichs-Graham, Alex I. Wiesman, Christine M. Embury, Mikki Schantell, Timothy R. Joe, Jacob A. Eastman, Tony W. Wilson
Summary: This study investigated the impact of motor responses on visual oscillatory activity using magnetoencephalography. The results showed a significant increase in occipital alpha power during movement, while gamma oscillations remained unaffected. These findings are important for understanding visuomotor integration and task design in complex visual processing.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Review
Neurosciences
Junseok A. Kim, Karen D. Davis
Summary: Magnetoencephalography (MEG) is a technology for measuring magnetic fields generated by neuronal activity in the brain, providing high temporal resolution. The review focuses on basic features, source localization techniques, functional coupling metrics in MEG, as well as current and future applications of MEG.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Cell Biology
Chloe E. Meehan, Mikki Schantell, Alex I. Wiesman, Sara L. Wolfson, Jennifer O'Neill, Sara H. Bares, Craig M. Johnson, Pamela E. May, Daniel L. Murman, Tony W. Wilson
Summary: People with HIV frequently experience mild cognitive decline, which can be attributed to either HIV-associated neurocognitive disorder (HAND) or early Alzheimer's disease (AD). This study used magnetoencephalography (MEG) to analyze brain activity during an attention task and found distinct neurophysiological patterns in AD and HAND patients, indicating unique oscillatory markers for each condition.
Article
Neuroimaging
Marie C. McCusker, Alex Wiesman, Rachel K. Spooner, Pamela M. Santamaria, Jennifer McKune, Elizabeth Heinrichs-Graham, Tony W. Wilson
Summary: The sequelae of Parkinson's disease include both motor and cognitive-related symptoms, with studies indicating neural differences in patients during multi-component movements. Patients with PD were slower in executing movement sequences and exhibited weaker neural activity in specific brain regions, suggesting impaired motor sequence execution. Understanding the cortical pathophysiology of PD could inform therapeutic interventions addressing both motor and cognitive symptoms.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Giorgia Picci, Lauren R. Ott, Samantha H. Penhale, Brittany K. Taylor, Hallie J. Johnson, Madelyn P. Willett, Hannah J. Okelberry, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson
Summary: The transition from childhood to adolescence is a critical period in which sex hormones play a significant role in shaping physical, behavioral, and neural development. This study investigated the impact of endogenous testosterone on spontaneous cortical activity in typically-developing youth. The findings revealed sex-specific effects of testosterone on different frequency bands of spontaneous cortical activity, particularly in the frontal cortices. These findings highlight the importance of testosterone in the development of cortical dynamics during adolescence, with distinct patterns observed between males and females.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Nathan M. Petro, Lauren R. Ott, Samantha H. Penhale, Maggie P. Rempe, Christine M. Embury, Giorgia Picci, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Tony W. Wilson
Summary: This study used MEG to record brain activity in typically developing youth during eyes-open and eyes-closed rest. The results showed that eyes-open condition had stronger neural activity, especially in the visual cortex. Additionally, the theta power in the frontal cortex became stronger with increasing age in the eyes-open condition. There were no differences observed between males and females.
Article
Neurosciences
Abril Rangel-Pacheco, Brandon J. Lew, Mikki D. Schantell, Michaela R. Frenzel, Jacob A. Eastman, Alex I. Wiesman, Tony W. Wilson
Summary: The study found that chronic cannabis users exhibited abnormal cognitive interference effects and altered neural dynamics in a visual selective attention task. Despite performing normally on the task, cannabis users showed differences in brain activity and connectivity compared to non-users.
PSYCHOPHARMACOLOGY
(2021)
Review
Clinical Neurology
Junseok A. Kim, Karen D. Davis
Summary: Neural oscillations are crucial for integrating and segregating brain regions important for brain functions, including pain. Specific functional bands, such as alpha, beta, and gamma bands, have been identified in nociceptive processing, illustrating the key role of regional and interregional neural oscillations in both acute and chronic pain.
Article
Neurosciences
Nicholas J. Christopher-Hayes, Brandon J. Lew, Alex I. Wiesman, Mikki Schantell, Jennifer O'Neill, Pamela E. May, Susan Swindells, Tony W. Wilson
Summary: The study examined the impact of cannabis use on brain and cognitive function in people with HIV (PWH). Results showed that PWH exhibited significant behavioral deficits in visuospatial processing, reduced theta oscillations, and elevated pre-stimulus gamma activity in visual cortices. However, chronic cannabis use was associated with a significant reduction in pre-stimulus gamma activity in visual cortices, potentially normalizing some neural aberrations in PWH.
HUMAN BRAIN MAPPING
(2021)
Article
Immunology
Rachel K. Spooner, Brittany K. Taylor, Iman M. Ahmad, Kelsey Dyball, Katy Emanuel, Jennifer O'Neill, Maureen Kubat, Susan Swindells, Howard S. Fox, Sara H. Bares, Kelly L. Stauch, Matthew C. Zimmerman, Tony W. Wilson
Summary: This study evaluates the predictive capacity of the mitochondrial redox environment on brain-behavior dynamics in people living with HIV. The findings suggest that oxidative stress plays a role in modulating the sensorimotor brain-behavior relationships in HIV patients. These findings provide insights for future research on therapeutic strategies for HIV-related cognitive-motor dysfunction.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Tim M. Tierney, Stephanie Mellor, George C. O'Neill, Ryan C. Timms, Gareth R. Barnes
Summary: This study investigates the interference rejection and spatial sampling properties of multi-axis Optically Pumped Magnetometer (OPM) data, finding that triaxial OPMs have excellent noise rejection properties and can adequately sample the neural space while minimizing cost, weight, and cross-talk.
Article
Psychology, Developmental
Brittany K. Taylor, Jacob A. Eastman, Michaela R. Frenzel, Christine M. Embury, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson
Summary: Selective attention processes in youth show sexually-divergent developmental trajectories, with interference tasks significantly modulating neural oscillations in specific brain regions. Males and females exhibit different patterns of neural oscillatory activity and age-related changes across various brain regions.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Molly Rea, Niall Holmes, Ryan M. Hill, Elena Boto, James Leggett, Lucy J. Edwards, David Woolger, Eliot Dawson, Vishal Shah, James Osborne, Richard Bowtell, Matthew J. Brookes
Summary: This study introduces the potential of optically-pumped magnetometers (OPMs) in magnetoencephalography (MEG) experiments and emphasizes the importance of controlling background magnetic fields. The authors propose a magnetic field mapping technique that accurately reconstructs field magnitude and compensates for it through an electromagnetic coil system, significantly reducing low-frequency interference. This technology can improve data quality in experiments, especially those measuring low-frequency oscillations or encouraging head movement.
Article
Neuroimaging
Kyung-min An, Takashi Ikeda, Chiaki Hasegawa, Yuko Yoshimura, Sanae Tanaka, Daisuke N. Saito, Ken Yaoi, Sumie Iwasaki, Tetsu Hirosawa, Ole Jensen, Mitsuru Kikuchi
Summary: By studying brain oscillations and their coupling in the primary motor cortex, alterations in neural mechanisms underlying motor dysfunction in children with ASD were revealed. These findings could potentially lead to the development of a biomarker for ASD diagnosis.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Clinical
Seth D. Springer, Rachel K. Spooner, Mikki Schantell, Yasra Arif, Michaela R. Frenzel, Jacob A. Eastman, Tony W. Wilson
Summary: This study used MEG technology to investigate differences in attentional function between regular cannabis users and non-users. Despite similar task performance, cannabis users showed differences in neural dynamics during attentional reorienting compared to non-users.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Chloe E. Meehan, Christine M. Embury, Alex Wiesman, Mikki Schantell, Sara L. Wolfson, Jennifer O'Neill, Susan Swindells, Craig M. Johnson, Pamela E. May, Daniel L. Murman, Tony W. Wilson
Summary: This study examines the neural dynamics underlying visuospatial processing in individuals with HIV-associated neurocognitive disorder (HAND) and Alzheimer's disease (AD). The results show both common and unique neurophysiological alterations among patients with HAND and ADS disorders in regions serving visuospatial processing.
Article
Computer Science, Interdisciplinary Applications
Irina Belyaeva, Ben Gabrielson, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Julia M. Stephen, Tulay Adali
Summary: Identification of informative signatures from electrophysiological signals is important for understanding brain developmental patterns. This study proposes a tensor-based approach for extracting developmental signatures of multi-subject MEG data. The results demonstrate that this approach can produce descriptive features of the multidimensional MEG data and be used to study group differences in brain patterns and cognitive function of healthy children.
Article
Neurosciences
Anees Abrol, Zening Fu, Yuhui Du, Tony W. W. Wilson, Yu-Ping Wang, Julia M. M. Stephen, Vince D. D. Calhoun
Summary: The brain's functional architecture and organization undergo continuous development and modification throughout adolescence. This study systematically evaluated over 47,000 youth and adult brains to examine time-resolved functional connectivity patterns and found distinct differences between the two life stages, indicating an overall inverted U-shaped trajectory in the strengthening and modularization of functional coupling. These findings suggest greater synchrony and integration of the brain's functional connections beyond adolescence, with a gradual decline during healthy aging.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Christine M. Embury, Grace H. Lord, Andjela T. Drincic, Cyrus Desouza, Tony W. Wilson
Summary: Poor glycemic control in type 2 diabetes is associated with age-related cognitive decline, and this study aims to investigate its impact on the neural dynamics serving working memory. The results show that individuals with poorer glycemic control exhibit diminished neural responses in specific brain regions during encoding and maintenance phases of working memory, as well as enhanced activity in other regions. The activity in these regions significantly predicts task performance, with longer reaction times associated with poorer glycemic control. These findings highlight the importance of glycemic control for working memory and its underlying neural mechanisms.
Article
Neurosciences
Nathan M. Petro, Giorgia Picci, Christine M. Embury, Lauren R. Ott, Samantha H. Penhale, Maggie P. Rempe, Hallie J. Johnson, Madelyn P. Willett, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Gaelle E. Doucet, Tony W. Wilson
Summary: Assessing brain connectivity during rest has become a widely used approach to identify changes in functional brain organization during development. In our study, we examined spontaneous cortical activity during eyes-closed rest using MEG in typically developing youth. Connectivity was estimated in different frequency bands and specific changes were observed with increasing age. These findings contribute to our understanding of the developmental changes in brain organization and highlight the importance of multispectral functional connectivity.
Article
Neurosciences
Seth D. Springer, Tara D. Erker, Mikki Schantell, Hallie J. Johnson, Madelyn P. Willett, Hannah J. Okelberry, Maggie P. Rempe, Tony W. Wilson
Summary: This study investigated the effects of aging on visual entrainment responses in healthy adults. The results showed that with increasing age, the amplitude of entrainment responses decreased and the latency of these responses increased. However, there was no age effect on the trial-to-trial consistency in phase or amplitude of visual responses.
Article
Neurosciences
Michael P. Trevarrow, Hannah E. Bergwell, Boman R. Groff, Alex I. Wiesman, Tony W. Wilson, Max J. Kurz
Summary: There are clinical reports indicating that youth with cerebral palsy (CP) have deficits in proprioception, stereognosis, and tactile discrimination. It is believed that these altered perceptions are due to abnormal somatosensory cortical activity during stimulus processing. However, this conjecture has not been tested.
Article
Neurosciences
Lucas Weyrich, Yasra Arif, Mikki Schantell, Hallie J. Johnson, Madelyn P. Willett, Hannah J. Okelberry, Tony W. Wilson
Summary: This study aimed to investigate the cognitive effects of cannabis polysubstance use. The results showed that cannabis-only users had weaker occipital theta during visuospatial processing, while polysubstance users had reduced beta connectivity in the occipital to prefrontal and occipital to left temporal cortices.
PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Developmental
Jake J. Son, Mikki Schantell, Giorgia Picci, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Gaelle E. Doucet, Brittany K. Taylor, Tony W. Wilson
Summary: The default mode network (DMN) is important for internal self-processing, rumination, and social functions. Disruptions in DMN connectivity during adolescence have been linked to early adversity and psychopathology. This study examined the impact of subclinical psychiatric symptoms on DMN connectivity during puberty. It found that depressive symptoms were associated with decreased connectivity over time, while posttraumatic stress symptoms were associated with increased connectivity. These findings suggest that DMN may play a role in mental health disorders.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Review
Cell Biology
Chloe C. Casagrande, Maggie P. Rempe, Seth D. Springer, Tony W. Wilson
Summary: With the aging population and the rise of cognitive decline and neurodegenerative disorders, understanding Alzheimer's disease (AD) has become crucial. Neuroimaging, including PET, fMRI, MEG, and EEG, has provided novel insights into AD pathology. This review focuses on task-based M/EEG studies since 2010, investigating cognitive domains most affected by AD and recommending adjustments for optimal use in this population.
AGEING RESEARCH REVIEWS
(2023)
Editorial Material
Clinical Neurology
Anto I. Bagic, Susan M. Bowyer, Richard C. Burgess, Michael E. Funke, Andrea Lowden, Ismail S. Mohamed, Tony Wilson, Wenbo Zhang, Andrew J. Zillgitt, Jeffrey R. Tenney
Summary: One of the major challenges in modern epileptology is the underutilization of epilepsy surgery for patients with medication-resistant epilepsy. Magnetoencephalography (MEG) is a clinically validated method that can improve surgical candidate identification and pre-surgical planning, but its usage in USA epilepsy centers is limited. The current MEG sensor technology, which employs SQUIDs, has limitations and advancements, such as optically pumped magnetometers (OPMs), are eagerly awaited. However, there are currently no OPM devices ready for practical clinical use.
Article
Neurosciences
Chloe E. Meehan, Mikki Schantell, Seth D. Springer, Alex I. Wiesman, Sara L. Wolfson, Jennifer O'Neill, Daniel L. Murman, Sara H. Bares, Pamela E. May, Craig M. Johnson, Tony W. Wilson
Summary: People with HIV often develop cognitive impairments known as HIV-associated neurocognitive disorder (HAND) and the cognitive dysfunction in older individuals with HIV may also be due to age-related disorders such as Alzheimer's disease (AD). This study investigated the neural dynamics during cognitive interference in patients on the AD spectrum (ADS), patients with HAND, and healthy aging controls. The results revealed both overlapping and distinct neurophysiological abnormalities in key motor and cognitive regions during cognitive interference, providing new evidence for distinct neuropathology.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Yasra Arif, Alex I. Wiesman, Nicholas Christopher-Hayes, Hannah J. Okelberry, Hallie J. Johnson, Madelyn P. Willett, Tony W. Wilson
Summary: The presence of conflicting stimuli negatively affects behavioral outcomes, either at the stimulus or response level, or both. Cognitive control is necessary for interference resolution, as it filters irrelevant information and allocates neural resources to task-related goals. However, the changes in neural dynamics related to cognitive control in healthy aging are poorly understood.
Article
Psychology, Developmental
Giorgia Picci, Nathan M. Petro, Jake J. Son, Oktay Agcaoglu, Jacob A. Eastman, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Brittany K. Taylor, Tony W. Wilson
Summary: Transdiagnostic indicators related to neurobiological processes have provided insights into the risk for psychopathology in youth over the past decade. Exposure to childhood trauma and dysregulation can lead to psychopathology and altered neural functioning. This longitudinal study found that trauma exposure predicted increased connectivity between cognitive control and default mode networks, while dysregulation predicted decreased within-network connectivity in the cognitive control network.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)