Article
Neurosciences
Christina S. Dintica, Tina Hoang, Norrina Allen, Stephen Sidney, Kristine Yaffe
Summary: Metabolic syndrome (MetS) is associated with lower cognition and microstructural brain alterations in midlife.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Oncology
Shefali Chaudhary, Alicia Roy, Christine Summers, Tim Ahles, Chiang -Shan R. Li, Herta H. Chao
Summary: This study has found that androgen deprivation therapy (ADT) may lead to cognitive deficits and impaired white matter integrity in prostate cancer patients. It is the first investigation of the influence of ADT on white matter integrity, and the findings indicate that 6 months of ADT can affect white matter integrity and is associated with slower processing speed.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Psychiatry
Nahrie Suk Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Seowoo Kim, Sun-Young Moon, Silvia Kyungjin Lho, Sanghoon Oh, Jun Soo Kwon
Summary: The study found that in patients with first-episode psychosis, ToM strange story scores were positively correlated with the white matter integrity of the left cingulum and left SLF. This suggests that the left cingulum and SLF may constitute a neural basis for ToM deficits in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Kristina Valatkeviciene, Oron Levin, Milda Sarkinaite, Wouter A. J. Vints, Rimante Kunickaite, Greta Danyle, Simona Kusleikiene, Samrat Sheoran, Vida J. Cesnaitiene, Nerijus Masiulis, Uwe Himmelreich, Rymante Gleizniene
Summary: In this study, a multimodal approach was used to investigate the associations between structural and neurochemical changes in relation to mild cognitive impairment (MCI). The findings suggest that the biochemical integrity of the hippocampus and cingulate cortex is associated with the microstructural organization of ipsilateral white matter tracts originating in the hippocampus. Elevated myo-inositol may be an underlying mechanism for decreased connectivity between the hippocampus and the prefrontal/cingulate cortex in MCI.
Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michele Porcu, Luigi Cocco, Riccardo Cau, Jasjit S. Suri, Lorenzo Mannelli, Josep Puig, Yang Qi, Kosmas I. Paraskevas, Luca Saba
Summary: The study aimed to analyze the mid-term effects of CEA on cognition and whole brain white matter microstructure, and the results showed a significant increase in MMSE scores and improvement in whole brain white matter microstructure 12 months following CEA.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Xinyuan Shang, Xianyue Meng, Xinxing Xiao, Zhentao Xie, Xiaoling Yuan
Summary: The study found that grip training can improve cognitive function by increasing the local efficiency of brain white matter connectivity, suggesting that white matter remodeling is a potential physiological mechanism connecting grip training and cognition improvement.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Article
Cell Biology
Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Matthew F. S. Rushworth, Heidi Johansen-Berg
Summary: Evidence suggests that white matter plasticity in humans follows Hebb's rule. Stimulation of cortical areas leads to increased cortical excitability and a myelin marker in the stimulated fiber bundle, indicating the presence of Hebbian plasticity in human white matter fibers.
Article
Immunology
Aoife O'Donovan, Amber Bahorik, Stephen Sidney, Lenore J. Launer, Kristine Yaffe
Summary: The study found that increasing or high inflammation trajectories from early to mid adulthood are associated with worse brain health, as indexed by lower white matter volume and/or worse white matter integrity.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Susanne Koehler, Ulrike Winkler, Johannes Hirrlinger
Summary: Astrocytes are a diverse and heterogeneous type of glial cells, with differential properties in grey and white matter areas of the brain. These cells vary in morphology, gene expression, metabolism, and other properties based on their local environment requirements. The heterogeneity of astrocytes may contribute to the different susceptibility of grey and white matter to ischemic insults.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Neda Rashidi-Ranjbar, Tarek K. Rajji, Colin Hawco, Sanjeev Kumar, Nathan Herrmann, Linda Mah, Alastair J. Flint, Corinne E. Fischer, Meryl A. Butters, Bruce G. Pollock, Erin W. Dickie, Christopher R. Bowie, Matan Soffer, Benoit H. Mulsant, Aristotle N. Voineskos
Summary: This study compared resting state functional connectivity in older adults with major depressive disorder (MDD) or mild cognitive impairment (MCI), and found that the alterations in functional connectivity in certain brain networks were associated with an increased risk of cognitive impairment.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Review
Pharmacology & Pharmacy
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Rayyan Zuberi, Roseann S. Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Muller
Summary: In this study, the association between six ABCB1 single-nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes was investigated through a systematic review and meta-analysis. No significant association was found between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. However, a significant association between rs1128503 and treatment response was observed in the meta-analysis. These findings provide limited evidence for the implementation of ABCB1 genotyping to inform antidepressant treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Lindsay M. Melhuish Beaupre, Michael Wainberg, Clement C. Zai, Milos Milic, Daniel Felsky, Gregory Brown, Benjamin Goldstein, Shreejoy J. Tripathy, James L. Kennedy, Vanessa F. Goncalves
Summary: This study conducted genome-wide association studies on UK Biobank participants and found a bidirectional relationship between sleep disturbances and depression, as well as the involvement of mitochondria in sleep biology. The results suggest that common genetic variations and mitochondria may play a role in sleep characteristics among depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Alastair J. Flint, Kathleen S. Bingham, George S. Alexopoulos, Patricia Marino, Benoit H. Mulsant, Nicholas H. Neufeld, Anthony J. Rothschild, Aristotle N. Voineskos, Ellen M. Whyte, Barnett S. Meyers
Summary: This study aimed to identify a prediction model for the risk of relapse in psychotic depression and examine if predictors moderated the effect of treatment on relapse. The number of depressive episodes, severity of residual depressive symptoms, and psychomotor disturbance predicted the risk of relapse. Multivariable models had an accuracy of 69-70% in predicting relapse. Future research is needed to determine if a combination of clinical and biological variables can improve the accuracy of predicting relapse in psychotic depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Xinyue Jiang, Alysha A. Sultan, Mikaela K. Dimick, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh, Benjamin Goldstein
Summary: This study found that the CACNA1C rs1006737 A allele is associated with resting-state functional connectivity (rsFC) in youth with bipolar disorder (BD) in regions relevant to emotion, executive function, and reward. Future task-based approaches are necessary to further understand the brain connectivity related to CACNA1C in BD.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Review
Psychiatry
Brett D. M. Jones, Madeha Umer, Mary E. Kittur, Ofer Finkelstein, Siqi Xue, Mikaela K. Dimick, Abigail Ortiz, Benjamin I. Goldstein, Benoit H. Mulsant, Muhammad I. Husain
Summary: This systematic review examined the efficacy of dialectical behavior therapy (DBT) for mood symptoms in patients with bipolar disorder (BD), finding that DBT may be effective in improving core symptoms of BD. However, limited sample sizes, heterogeneity, and high risk of bias in the included trials limit the confidence in this conclusion. Larger, well-designed randomized controlled trials are needed to establish the effectiveness of DBT in BD.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Health Care Sciences & Services
Lenka Vojtila, Diana Sherifali, Rosa Dragonetti, Iqra Ashfaq, Scott Veldhuizen, Farooq Naeem, Sri Mahavir Agarwal, Osnat C. Melamed, Allison Crawford, Philip Gerretsen, Margaret Hahn, Sean Hill, Sean Kidd, Benoit Mulsant, Eva Serhal, Leah Tackaberry-Giddens, Carly Whitmore, Jennifer Marttila, Frank Tang, Seeta Ramdass, Gloria Lourido, Sanjeev Sockalingam, Peter Selby
Summary: This study aims to test the feasibility of a technology-enabled collaborative care (TECC) model for diabetes management and mental health support among adults with T2D. Thirty adults with T2D in Ontario, Canada will participate in an 8-week web-based health coaching program supported by a digital care team. The study results, expected to be available by the end of 2023, will provide valuable insights for supporting individuals with T2D and mental health challenges.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Parnian Puramat, Mikaela K. Dimick, Kody G. Kennedy, Clement C. Zai, James L. Kennedy, Bradley J. MacIntosh, Benjamin Goldstein
Summary: This study found that the APOE epsilon 4 gene is associated with neurostructural differences in individuals with bipolar disorder (BD) and controls, but the regional differences in neurostructures between the two groups were significant. This suggests that APOE epsilon 4 may have important implications for neurodevelopmental processes.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Navona Calarco, Lindsay D. Oliver, Michael Joseph, Colin Hawco, Erin W. Dickie, Pamela DeRosse, James M. Gold, George Foussias, Miklos Argyelan, Anil K. Malhotra, Robert W. Buchanan, Aristotle N. Voineskos, SPINS Grp
Summary: This study found a strong relationship between white matter circuitry and neurocognition and social cognition. The microstructure of the uncinate fasciculus and the rostral body of the corpus callosum played a significant role in this relationship. The participant-wise estimates of white matter microstructure, weighted by cognitive performance, were consistent with the participants' diagnosis and predictive of functional outcomes.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Muhammad Ishrat Husain, Nicole Ledwos, Elise Fellows, Jenna Baer, Joshua D. Rosenblat, Daniel M. Blumberger, Benoit H. Mulsant, David J. Castle
Summary: This article reviews the mechanisms underlying the antidepressant effect of serotonergic psychedelics, including their serotonin 2A agonist effects, impact on brain derived neurotrophic factor and immunomodulatory responses, and disruption of the default mode network. However, further research is needed to validate these mechanisms and determine which theories are supported by robust evidence.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
M. Ishrat Husain, Imran B. Chaudhry, Ameer B. Khoso, Tayyeba Kiran, Nawaz Khan, Farooq Ahmad, John Hodsoll, M. Omair Husain, Haider A. Naqvi, Asad T. Nizami, Nasim Chaudhry, Hazrat A. Khan, Fareed Minhas, Jeffrey H. Meyer, Moin A. Ansari, Benoit H. Mulsant, Nusrat Husain, Allan H. Young
Summary: This study aimed to assess the efficacy and tolerability of adjunctive simvastatin in reducing depressive symptoms in treatment-resistant depression (TRD). The results showed no significant differences between the simvastatin group and the placebo group in primary and secondary outcomes, and there were also no significant differences in adverse effects between the two groups. Therefore, simvastatin did not provide additional therapeutic benefit for depressive symptoms in TRD.
Review
Psychiatry
Tulip Marawi, Nicholas J. Ainsworth, Peter Zhukovsky, Neda Rashidi-Ranjbar, Tarek K. Rajji, Maria Carmela Tartaglia, Aristotle N. Voineskos, Benoit H. Mulsant
Summary: Most patients with late-life depression (LLD) have cognitive impairment, and at least one-third meet diagnostic criteria for mild cognitive impairment (MCI), a prodrome to Alzheimer's dementia (AD) and other neurodegenerative diseases. However, the mechanisms linking LLD and MCI, and brain alterations underlying impaired cognition in LLD and LLD + MCI remain poorly understood.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Xinyue Jiang, Clement C. Zai, Kody G. Kennedy, Yi Zou, Yuliya S. Nikolova, Daniel Felsky, L. Trevor Young, Bradley J. Macintosh, Benjamin I. Goldstein
Summary: This study found a negative association between a polygenic risk score for bipolar disorder (BD-PRS) based on adult genetic data and grey matter structure and white matter integrity in youth. These findings may provide clues for identifying neuroimaging markers of bipolar disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Correction
Psychiatry
M. Ishrat Husain, Madeha Umer, Muqaddas Asif, Ameer B. Khoso, Tayyeba Kiran, Moin Ansari, Huma Aslam, Moti Ram Bhatia, Farasat A. Dogar, M. Omair Husain, Hazrat A. Khan, Ali A. Mufti, Benoit H. Mulsant, Farooq Naeem, Haider A. Naqvi, Claire de Oliveira, M. Sajjad Siddiqui, Asad Tamizuddin, Wei Wang, Juveria Zaheer, Nusrat Husain, Nasim Chaudhry, Imran B. Chaudhry
