Review
Biochemistry & Molecular Biology
Samantha A. Moore, Angelo Iulianella
Summary: This review discusses the development of the cortical hem in the vertebrate brain, as well as the key signaling pathways and molecules involved in patterning this specialized region. It also highlights the connections between the formation of the lateral ventricle choroid plexus and neurogenesis in the hippocampus during embryonic and postnatal stages.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoya Chen, Dan Luo, Qiao Zheng, Yuling Peng, Yongliang Han, Qi Luo, Qiyuan Zhu, Tianyou Luo, Yongmei Li
Summary: This study investigated the correlation between choroid plexus volume and whole brain morphology in patients with MS and NMOSD. The findings showed that choroid plexus volumes were increased in the MS group but not in the NMOSD group. MS patients also exhibited reduced cortical thickness and increased ventricle system volume, while NMOSD patients showed increased third ventricle volume. Furthermore, the enlarged choroid plexus was associated with reduced cortical thickness in the MS group.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Neurosciences
Elisa Floriddia, Michal Schwartz
Summary: This article celebrates the 25th anniversary of Nature Neuroscience and discusses the evolution and future direction of the field through conversations with established leaders and emerging researchers. Michal Schwartz, a neuroimmunologist and pioneer in studying the role of the immune system in physiology and diseases of the central nervous system, is highlighted as the winner of the 2023 Israel Prize in Life Sciences.
NATURE NEUROSCIENCE
(2023)
Article
Veterinary Sciences
Guillaume Marc Albertini, Alexandra Malbon, Anne Staudacher, Fabio Stabile
Summary: A 2-year-old male Cane Corso was euthanized due to a week-long history of ambulatory paraparesis and pelvic limb ataxia. MRI revealed intraventricular and spinal drop metastases. Histological examination confirmed a primary ventricular choroid plexus papilloma causing disseminated metastases. This is the first reported case of such occurrence.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell & Tissue Engineering
Courtney L. McMahon, Hilary Staples, Michal Gazi, Ricardo Carrion, Jenny Hsieh
Summary: Researchers used human stem cell-derived brain organoids to study how SARS-CoV-2 infects brain tissue and found that glial cells and cells of the choroid plexus were preferentially targeted, while neurons were not infected. The expression of angiotensin-converting enzyme 2 was detected in infected cells, but viral replication and cell death did not occur, indicating that this model serves as a feasible platform to study the cellular effects of SARS-CoV-2 infection in brain tissue.
Article
Biochemistry & Molecular Biology
Lu Wang, David Sievert, Alex E. Clark, Sangmoon Lee, Hannah Federman, Benjamin D. Gastfriend, Eric V. Shusta, Sean P. Palecek, Aaron F. Carlin, Joseph G. Gleeson
Summary: Research findings suggest that pericytes may serve as important portals for SARS-CoV-2 infection in the nervous system. Introducing pericyte-like cells (PLCs) into cortical organoids can provide an experimental model that supports virus entry and replication.
Article
Multidisciplinary Sciences
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin, Maria K. Lehtinen
Summary: NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice, implicating NKCC1 in regulating CSF clearance in the critical period during postnatal neurodevelopment.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Samudyata, Ana O. Oliveira, Susmita Malwade, Nuno Rufino de Sousa, Sravan K. Goparaju, Jessica Gracias, Funda Orhan, Laura Steponaviciute, Martin Schalling, Steven D. Sheridan, Roy H. Perlis, Antonio G. Rothfuchs, Carl M. Sellgren
Summary: Neuropsychiatric manifestations are common in SARS-CoV-2 infection, but their mechanisms are unknown. Using a brain organoid model, researchers found that SARS-CoV-2 infection triggers neuronal cell death and disrupts circuit integrity through microglia-mediated synapse elimination, potentially contributing to cognitive impairments in COVID-19 patients.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Manuela Santo, Laura Rigoldi, Carmen Falcone, Mariacarmine Tuccillo, Michela Calabrese, Veronica Martinez-Cerdeno, Antonello Mallamaci
Summary: This study investigates the differentiation of pallial stem cells (SCs) and the progression of committed progenitors in the neonatal cerebral cortex. The researchers found that caudal-medial SCs are more prone to astrogenesis, while rostro-lateral committed progenitors are more likely to proliferate. The key transcription factor genes Emx2 and Foxg1 were found to play a role in regulating these processes, with Emx2 promoting astrogenesis and Foxg1 inhibiting it to some extent.
Article
Biochemistry & Molecular Biology
Laureana Muok, Chang Liu, Xingchi Chen, Colin Esmonde, Peggy Arthur, Xueju Wang, Mandip Singh, Tristan Driscoll, Yan Li
Summary: This study investigates the role of Wnt signaling in choroid plexus (ChP) organoids derived from human-induced pluripotent stem cells (hiPSCs). The presence of Wnt agonist upregulates the expression of ChP genes and increases the sensitivity to amyloid beta 42 oligomers. This study is significant for drug screening and designing drug delivery systems for neurological disorders such as Alzheimer's disease and ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Shashi Kant Tiwari, Shaobo Wang, Davey Smith, Aaron F. Carlin, Tariq M. Rana
Summary: Researchers generated iPSC-derived lung and brain organoids, finding that lung organoids are highly permissive to SARS-CoV-2 infection, while brain organoids are less susceptible. These findings will aid in understanding the pathogenesis of COVID-19 and drug discovery.
Article
Biology
Alessia Caramello, Christophe Galichet, Karine Rizzoti, Robin Lovell-Badge
Summary: During embryonic development, timely regulation of the switch between radial glial cells, neurons, and astrocytes is crucial for coordinated interactions in the brain. The deletion of the SOX9 gene in early mouse brain development resulted in compromised dentate gyrus development, highlighting the importance of SOX9 in regulating astroglial potential acquisition in the cortical hem. This study demonstrates the formation of a local network between astrocytic and neuronal progenitors from adjacent domains, essential for brain morphogenesis.
Article
Medicine, Research & Experimental
Pashayar P. Lookian, Vikram Chandrashekhar, Anthony Cappadona, Jean-Paul Bryant, Vibhu Chandrashekhar, Jessa M. Tunacao, Danielle R. Donahue, Jeeva P. Munasinghe, James G. Smirniotopoulos, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum
Summary: Through studying mice, a previously unknown transtentorial venous system (TTVS) connecting venous drainage throughout the brain in humans was discovered and confirmed to be conserved in mice. The research also revealed the drainage pathway of the tentorial plexus during embryonic stages and the importance of TTVS in the early postnatal period.
Article
Oncology
Manuel Pedro Jimenez-Garcia, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Summary: Sarcomas are a heterogeneous group of tumors with a functional hierarchy controlled by sarcoma stem cells. EMX genes play a role in sarcomagenesis by regulating tumor stem cells, with a negative impact on tumorigenic properties. The relationship between EMX1/EMX2 and stem cell genes in sarcoma involves the canonical Wnt pathway, where EMX genes negatively regulate Wnt signaling to repress stemness and induce sarcomagenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Chantelle Browne-Farmer, Lili-Naz Hazrati, Yasin Mamatjan, Gelareh Zadeh, Peter Dirks, James Rutka, David Malkin, Eric Bouffet, Annie Huang, Uri Tabori, Vijay Ramaswamy, Ute Bartels
Summary: Choroid plexus tumours, particularly atypical choroid plexus papillomas (aCPPs), are rare in children and there is no consensus on the optimal management approach. This study found that aCPP can be successfully managed with surgical resection alone, without the need for adjuvant therapies. Methylation profiling showed similarities between aCPPs, choroid plexus papillomas, and choroid plexus carcinomas.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Serena Diazzi, Alberto Baeri, Julien Fassy, Margaux Lecacheur, Oskar Marin-Bejar, Christophe A. Girard, Lauren Lefevre, Caroline Lacoux, Marie Irondelle, Carine Mounier, Marin Truchi, Marie Couralet, Mickael Ohanna, Alexandrine Carminati, Ilona Berestjuk, Frederic Larbret, David Gilot, Georges Vassaux, Jean-Christophe Marine, Marcel Deckert, Bernard Mari, Sophie Tartare-Deckert
Summary: This study demonstrates that the anti-fibrotic drug nintedanib can normalize the fibrous ECM network, enhance the effectiveness of MAPK-targeted therapy, and delay tumor relapse in a preclinical model of melanoma. The miR-143/-145 pro-fibrotic cluster plays a crucial role in the acquisition of drug resistance, and the mature miRNAs, miR-143-3p and miR-145-5p, mediate the transition towards a drug-resistant undifferentiated mesenchymal-like state. Preventing the pro-fibrotic stromal response induced by MAPKi treatment presents a viable therapeutic opportunity for melanoma patients.
EMBO MOLECULAR MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Shanna Dewaele, Louis Delhaye, Boel De Paepe, Eric James de Bony, Jilke De Wilde, Katrien Vanderheyden, Jasper Anckaert, Nurten Yigit, Justine Nuytens, Eveline Vanden Eynde, Joel Smet, Maxime Verschoore, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Peihua Zhao, Aart Jochemsen, Eleonora Leucci, Jo Vandesompele, Jo Van Dorpe, Jean-Christophe Marine, Rudy Van Coster, Sven Eyckerman, Pieter Mestdagh
Article
Oncology
Ward Celus, Ana Oliveira, Silvia Rivis, Heleen H. Van Acker, Ewout Landeloos, Jens Serneels, Sarah Trusso Cafarello, Yannick Van Herck, Roberta Mastrantonio, Arnaud Koehler, Abhishek D. Garg, Veronique Flamand, Luca Tamagnone, Jean-Christophe Marine, Mario Di Matteo, Bruno M. Costa, Oliver Bechter, Massimiliano Mazzone
Summary: The infiltration of cytotoxic T cells (CTL) into tumors has the potential to limit cancer progression. However, the immunosuppressive tumor microenvironment hampers the effectiveness of immunotherapy. This study shows that the axon guidance molecule Plexin-A4 (Plxna4) negatively regulates CTL migration and proliferation through cell-autonomous mechanisms. Deletion of Plxna4 improves the homing capacity of CTLs to lymph nodes and tumors, as well as enhances their proliferation. Furthermore, adoptive transfer of Plxna4-deficient CTLs prolongs survival in a melanoma model and shows improved therapeutic outcome when combined with anti-programmed cell death protein 1 (PD-1) treatment. These findings suggest that Plxna4 can serve as a potential target for immunotherapies and its detection in circulating CTLs may be a way to monitor the response to immune checkpoint blockade in melanoma patients with metastasis.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Leah Schembs, Ariane Willems, Kerstin Hasenpusch-Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M. K. Bostrand, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Thomas Theil
Summary: This study reveals the importance of primary cilia in dorsal and ventral patterning in human corticogenesis, identifies the tissue-specific role of the INPP5E gene as a negative regulator of SHH signaling, and suggests implications for the pathogenesis of neurodevelopmental disorders.
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Article
Oncology
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M. Cuadros, Emma Nolan, Juan Fernandez-Garcia, Qi Wu, Melanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurelie Montagne, Margherita Demicco, H. Furkan Alkan, Nick Rabas, Carla Riera-Domingo, Francois Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V. Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Veronique Baud, Thomas G. P. Gruenewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
Summary: The formation of pre-metastatic niche and high-fat diet can increase palmitate availability in future organs of metastases, promoting NF-kappa B acetylation and inducing metastatic signaling. Deletion of acetyltransferase and palmitoyltransferase reduces metastasis formation.
Review
Biochemistry & Molecular Biology
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Haecker, Gyorgy Hajnoczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jaeaettelae, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Munoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Nunez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Summary: Apoptosis is a regulated cell death process involving caspase family proteases. Inhibiting or delaying apoptosis experimentally through pharmacological and genetic strategies has demonstrated its importance in embryonic development, tissue homeostasis, and the pathogenesis of various human disorders. Defects in apoptotic cell death machinery impair development and promote oncogenesis, while inappropriate activation of apoptosis contributes to cell loss and tissue damage in neurological, cardiovascular, renal, hepatic, infectious, neoplastic, and inflammatory conditions.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Developmental Biology
Rana Fetit, Michela Ilaria Barbato, Thomas Theil, Thomas Pratt, David J. Price
Summary: Inhibitory interneurons play a key role in regulating cortical circuit activity and their dysfunction is associated with autism spectrum disorder (ASD). This study investigates the effects of a genetic microdeletion, 16p11.2, which is linked to ASD, on the development of interneurons. Using human induced pluripotent stem cells, the researchers found that the microdeletion leads to increased variability in organoid size, neural rosette area, and expression of specific markers. The microdeletion also lengthens the cell cycle of ventral progenitors, promoting premature differentiation into interneurons.
Article
Oncology
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Melanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O'Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. V. Swinnen
Summary: This study identifies the role of FASN in therapy resistance in cancer. By inhibiting FASN and inducing ROS, therapy resistance can be delayed. The combination of MAPK inhibitors, FASN inhibitors, and ROS inducers significantly increases survival in therapy-resistant models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Loeffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdoerfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Pozniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hoelzel, Iris Helfrich
Summary: This study identified HSD11B1 as a negative feedback mechanism that limits the efficacy of PD-1 blockade, and showed that HSD11B1 inhibitors can enhance the effectiveness of immunotherapy for melanoma. Additionally, high levels of HSD11B1 were associated with poor responses to immune checkpoint inhibitors in patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Juliana C. N. Kenski, Xinyao Huang, David W. Vredevoogd, Beaunelle de Bruijn, Joleen J. H. Traets, Sofia Ibanez-Molero, Sebastiaan M. Schieven, Alex van Vliet, Oscar Krijgsman, Thomas Kuilman, Joanna Pozniak, Fabricio Loayza-Puch, Alexandra M. Terry, Judith Mueller, Meike E. W. Logtenberg, Marjolein de Bruijn, Pierre Levy, Pierre-Rene Korner, Colin R. Goding, Ton N. Schumacher, Jean-Christophe Marine, Reuven Agami, Daniel S. Peeper
Summary: By restoring tryptophan, IDO1 inhibitors aim to reactivate anti-tumor T cells. However, inhibiting IDO1 can lead to an adverse protection of melanoma cells to T cell-derived IFNg. This is accompanied by impaired translation and a stress response that downregulates MITF, contributing to T cell resistance and potentially impacting patient outcome.
CELL REPORTS MEDICINE
(2023)
Correction
Cell Biology
Adrian P. Bracken, Daniela Kleine-Kohlbrecher, Nikolaj Dietrich, Diego Pasini, Gaetano Gargiulo, Chantal Beekman, Kim Theilgaard-Monch, Saverio Minucci, Bo T. Porse, Jean-Christophe Marine, Klaus H. Hansen, Kristian Helin
GENES & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Ronan Le Senechal, Marc Keruzore, Alicia Quillevere, Nadege Loaec, Van-Trang Dinh, Oksana Reznichenko, Pedro Guixens-Gallardo, Laurent Corcos, Marie-Paule Teulade-Fichou, Anton Granzhan, Marc Blondel
Summary: BCL-x is a master regulator of apoptosis and its alternative splicing is controlled by RBM25. RBM25 directly binds to an RNA G-quadruplex near the alternative splice site of BCL-x pre-mRNA, promoting the production of the pro-apoptotic Bcl-xS isoform. PhenDC3 and two newly discovered compounds, PhenDH8 and PhenDH9, enhance the binding of RBM25 to the G-quadruplex, thereby promoting apoptosis. This study highlights the importance of the RBM25/G-quadruplex interaction in sensitizing cancer cells to chemotherapy.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hyungsoo Kim, Yongmei Feng, Rabi Murad, Joanna Pozniak, Carl Pelz, Yeqing Chen, Bhavik Dalal, Rosalie Sears, Eduard Sergienko, Michael Jackson, Eytan Ruppin, Meenhard Herlyn, Curtis Harris, Jean-Christophe Marine, Victoria Klepsch, Gottfried Baier, Ze'ev A. Ronai
Summary: The orphan nuclear receptor NR2F6 has a tumor-intrinsic function in regulating antitumor immunity. It plays a role in tumor development and the abundance of CD8(+) T cells. Blocking NR2F6 enhances the efficacy of PD-1 therapy and could be a promising anticancer treatment strategy.
Review
Oncology
Ada Nowosad, Jean-Christophe Marine, Panagiotis Karras
Summary: Tumors are complex ecosystems consisting of cancer cells and immune cells, which communicate bidirectionally and influence tumor growth and metastasis. The tumor vasculature and perivascular niche play important roles in promoting cancer stemness, immune evasion, dormancy, and metastatic spreading. These findings have significant implications for cancer research and therapy.