Article
Radiology, Nuclear Medicine & Medical Imaging
Liesbeth Reneman, Marieke van der Pluijm, Anouk Schrantee, Elsmarieke van de Giessen
Summary: The dopamine system in the brain plays a crucial role in various neurologic and psychiatric disorders, with PET and SPECT being used to visualize and measure different aspects of the system. New developments in MR imaging offer alternative ways to assess the dopamine system, with techniques like phMRI and NM-MRI showing promise for clinical application.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Article
Neurosciences
Tiantian Qiu, Fei Xie, Qingze Zeng, Zhujing Shen, Guijin Du, Xiaopei Xu, Chao Wang, Xiaodong Li, Xiao Luo, Kaicheng Li, Peiyu Huang, Tianyi Zhang, Jinling Zhang, Shouping Dai, Minming Zhang
Summary: Cigarette smoking may affect the functioning of cortico-striatal circuits in patients with Alzheimer's disease. The study suggests that quitting smoking in the early stages of AD may have the potential to prevent disease progression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Fernando Caravaggio, Alexander J. Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero
Summary: This study investigated the effects of AMPT-induced dopamine depletion on resting-state functional connectivity of the basal ganglia and canonical resting-state networks in healthy individuals. The results showed reduced connectivity between the caudate and the medial prefrontal cortex, as well as decreased connectivity between several brain regions and the occipital cortex, while increased connectivity was observed between the dorsal caudate and the sensorimotor network. AMPT also significantly decreased self-reported motivation and increased fatigue. Moreover, greater fatigue was associated with reduced connectivity between the substantia nigra and the medial prefrontal cortex, and decreased motivation was correlated with decreased connectivity between the ventral tegmental area and the left sensorimotor cortex.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Filip Grill, Jarkko Johansson, Jan Axelsson, Patrik Brynolfsson, Lars Nyberg, Anna Rieckmann
Summary: This study used a combination of PET and fMRI to reveal the different functions of striatal dopamine during finger tapping. Dopamine release in the putamen may be related to motor processes, while dopamine release in regions such as the caudate may represent cognitive components of the task, showing an interplay between motor and non-motor-related dopamine release during finger tapping.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Martin Fungisai Gerchen, Franziska Weiss, Martina Kirsch, Alena Rentsch, Patrick Halli, Falk Kiefer, Peter Kirsch
Summary: This study developed a circuit-specific fMRI analysis approach to detect dynamic changes in frontostriatal functional connectivity in AUD patients. The results consistently showed a ventral shift in right orbitofrontal cortex PeaCoG in AUD patients, and reduced temporospatial variability of dynamic PeaCoG in the left dorsolateral prefrontal cortex was associated with self-efficacy and days of abstinence.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
Guanmao Chen, Pan Chen, JiaYing Gong, Yanbin Jia, Shuming Zhong, Feng Chen, Jurong Wang, Zhenye Luo, Zhangzhang Qi, Li Huang, Ying Wang
Summary: This study investigated the shared and specific patterns of dynamic functional connectivity (dFC) variability of the striato-cortical circuitry in bipolar disorder (BD) and major depressive disorder (MDD). The results showed that both BD and MDD patients had common dFC alterations in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries, while MDD patients had specific dFC alterations in the ventral striatal-affective circuitry.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Oncology
Ryan C. Perez, DaeHee Kim, Aaron W. P. Maxwell, Juan C. Camacho
Summary: The association between hypoxia, cancer aggressiveness, and decreased therapeutic response is well-established. This review aims to summarize the molecular pathways associated with tumor hypoxia and the use of PET and MRI techniques for imaging hypoxia in cancer. It also discusses future directions and challenges in this field.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiayu Wu, Ming Gao, Ruiqing Piao, Nana Feng, Bowen Geng, Peng Liu
Summary: The study compared the gray matter volume of the striatum between LPE patients and healthy controls, finding that LPE patients had significantly decreased GMV in four regions located in the bilateral caudate and putamen. Unique striatum-based structural covariance patterns in the two groups were mainly related to various brain regions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Kavya Prasad, Erik F. J. de Vries, Philip H. Elsinga, Rudi A. J. O. Dierckx, Aren van Waarde
Summary: Adenosine and dopamine interact antagonistically in living mammals via adenosine A(2A) and dopamine D-2 receptors. These interactions mainly occur in striatal neurons and astrocytes, and may have therapeutic potential for Parkinson's disease, schizophrenia, substance abuse, and attention deficit-hyperactivity disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Clinical
Sonia Membrives, Marina Lopez-Sola, Fernando Fernandez-Aranda, Isabel Sanchez, Ignacio Martinez-Zalacain, Diego Palao, Jesus Pujol, Jose M. Menchon, Chris G. Davey, Ben J. Harrison, Charlotte Keating, Susan L. Rossell, Joan C. Oliva, Carles Soriano-Mas, Narcis Cardoner, Esther Via
Summary: Research using functional magnetic resonance imaging (fMRI) found that individuals with anorexia nervosa (AN) exhibit altered response patterns in the ventral striatum (VS) during repetitive social rejection, along with difficulty returning to baseline levels. These findings suggest potential targets for future studies exploring temporal dynamics in AN.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Biochemical Research Methods
Marius E. Mayerhoefer, Lale Umutlu, Heiko Schoeder
Summary: Lymphomas are ideal targets for radiomics due to their distinct characteristics, and functional imaging tests play a crucial role in diagnosing and predicting treatment outcomes for lymphoma. However, more data is needed to support the application of radiomics in lymphoma due to differences in lymphoma subtypes and increasing treatment options.
Article
Engineering, Multidisciplinary
Amir Mohammad Ghani Dehkordi, Alireza Kashaninia, Fardad Farokhi, Nader Jafarnia Dabanloo
Summary: This study presents a five-step algorithm to determine functional brain connections in Alzheimer's disease using Molecular Dynamics method in functional MRI images. The results indicate a significant decrease in memory connections over time in Alzheimer's patients.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Neurosciences
Hui Wang, Jianxia Xu, Miao Yu, Gaiyan Zhou, Jingru Ren, Yajie Wang, Huifen Zheng, Yu Sun, Jun Wu, Weiguo Liu
Summary: This study aimed to explore the potential clinical utility of functional and structural magnetic resonance imaging (MRI) in the diagnosis of depression in Parkinson's disease (DPD). The results showed that both the ReHo value of the left dorsolateral superior frontal gyrus and the DC value of the left inferior temporal gyrus were equally well suited for the diagnosis and differential diagnosis of DPD, with a combination of them being slightly preferable. The multimodal MRI technique represents a promising approach for the classification of subjects with PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Psychology, Developmental
Annie Bryant, Hope Schlesinger, Athina Sideri, Joni Holmes, Jan Buitelaar, Richard Meiser-Stedman
Summary: This meta-analytic review examined the effects of medications on anxiety and depression symptoms in children and adolescents with ADHD. The study found no significant improvement in symptoms of anxiety or depression with ADHD medication compared to placebo control. The lack of reporting on mental health outcomes in ADHD drug trials for children and adolescents was highlighted, emphasizing the importance of standardized measurement in future trials.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Nathalie E. Holz, Dorothea L. Floris, Alberto Llera, Pascal M. Aggensteiner, Seyed Mostafa Kia, Thomas Wolfers, Sarah Baumeister, Boris Boettinger, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Steve C. R. Williams, Paramala Santosh, Mireia Rosa-Justicia, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Susanne Walitza, Andreas Meyer-Lindenberg, Marcel Zwiers, Barbara Franke, Jan Buitelaar, Jilly Naaijen, Daniel Brandeis, Christian Beckmann, Tobias Banaschewski, Andre F. Marquand
Summary: This study aimed to reveal the neurobiological characteristics of disruptive behavior disorders (DBD) by integrating individual deviation patterns from multiple imaging modalities. The results showed that DBD patients exhibited increased age-related deviations in the amygdala, suggesting a possible maturational delay. Furthermore, the study identified neural signatures associated with aggression, including the default mode network (DMN), striatum, and amygdala.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Substance Abuse
Monja Hoven, Renee S. Schluter, Arnt F. Schellekens, Ruth J. van Holst, Anna E. Goudriaan
Summary: This study examined the effects of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on alcohol use and craving by targeting the right dorsolateral pre-frontal cortex. The results showed no significant impact of HF-rTMS on abstinent days and craving.
Article
Psychology, Multidisciplinary
Patricia Romero Verdugo, Lieke L. F. van Lieshout, Floris P. de Lange, Roshan Cools
Summary: This study demonstrates that humans exhibit higher curiosity and are more willing to wait for the outcome when they have the choice in selecting the information. This has implications for boosting learning, memory, and motivation.
PSYCHOLOGICAL SCIENCE
(2023)
Article
Behavioral Sciences
Ping Chen, Dirk E. M. Geurts, Jessica Maatta, Ruben van den Bosch, Lieke Hofmans, Danae Papadopetraki, Hanneke den Ouden, Roshan Cools
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Substance Abuse
Pauline Geuijen, Arnt Schellekens, Aart Schene, Femke Atsma
Summary: This study compared the prevalence of clinical substance use disorder (SUD) diagnoses and alcohol consumption patterns between physicians and a highly educated reference population using nationwide register data. The results showed that the prevalence rates of SUD diagnoses were relatively low for both physicians and the reference population, but physicians had more favorable alcohol consumption patterns. However, the use of sedatives among physicians might require attention.
ADDICTION SCIENCE & CLINICAL PRACTICE
(2023)
Review
Psychology, Developmental
P. Santosh, S. Cortese, C. Hollis, S. Bolte, D. Daley, D. Coghill, M. Holtmann, E. J. S. Sonuga-Barke, J. Buitelaar, T. Banaschewski, A. Stringaris, M. Doepfner, S. Van der Oord, S. Carucci, D. Brandeis, P. Nagy, M. Ferrin, D. Baeyens, B. J. van den Hoofdakker, D. Purper-Ouakil, A. Ramos-Quiroga, M. Romanos, C. A. Soutullo, A. Thapar, I. C. K. Wong, A. Zuddas, C. Galera, E. Simonoff
Summary: The COVID-19 pandemic has led to changes in ADHD services, with remote assessments being widely adopted. However, there is a lack of clear guidance on how to conduct these assessments effectively. Therefore, the European ADHD Guidelines Group discusses the strengths and weaknesses of remote assessments and provides recommendations for future studies and clinical practice.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Behavioral Sciences
Hannah Ellerbroek, Imke Hanssen, Karen Lathouwers, Linda Cillessen, Sander Dekkers, Stijn E. Veldman, Sandra A. S. van den Heuvel, Anne E. M. Speckens, Arnt F. A. Schellekens
Summary: This qualitative pilot study explored the feasibility and process of change during mindfulness-based cognitive therapy (MBCT) in patients with chronic pain and opioid use disorder (OUD). The findings showed that while MBCT treatment was beneficial for some patients, it was not feasible for the majority. Changing the timing of MBCT and offering it in an online format may improve participation.
BRAIN AND BEHAVIOR
(2023)
Review
Psychiatry
Pim B. van der Meer, Juan J. Fuentes, Ad A. Kaptein, Jan W. Schoones, Marleen M. de Waal, Anneke E. Goudriaan, Kees Kramers, Arnt Schellekens, Metten Somers, Matthijs G. Bossong, Albert Batalla
Summary: This systematic review found that using significant doses of psilocybin in combination with psychotherapy was effective in treating patients with substance use disorders and non-substance-related disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Sophie Gimbach, Daniel Vogel, Roland Fried, Stephen Faraone, Tobias Banaschewski, Jan Buitelaar, Manfred Doepfner, Richard Ammer
Summary: The study aims to measure the impact of the COVID-19 pandemic on global and national consumption of ADHD medication using pharmaceutical sales data from 2014 to 2021 across 47 countries. A SARIMA model was used to predict medication consumption in 2020 and 2021 based on historical data. The findings show that the pandemic resulted in a significant decrease in ADHD medication consumption in 2020, but an increase in consumption in 2021, with a strong correlation to government anti-pandemic policies.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Esther Pars, Joanne E. L. VanDerNagel, Boukje A. G. Dijkstra, Arnt F. A. Schellekens
Summary: This study explores the viability of using negative recovery capital (NRC) in individuals with substance use disorder (SUD), psychiatric comorbidities, and an intellectual disability. The study finds that all recovery domains are prevalent and relevant, influenced by critical life events, and individuals prioritize individual skill development during treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Experimental
Ceyda Sayali, Emma Heling, Roshan Cools
Summary: This study examined the preference for challenging tasks and found that difficult tasks increase engagement and liking. The learning progress motivation hypothesis states that people choose difficult tasks because they provide a dynamic range for changes in task performance. The results confirm this hypothesis.
Letter
Medicine, General & Internal
Gerard A. Kalkman, Cornelis Kramers, Wim van den Brink, Arnt F. A. Schellekens
Letter
Medicine, General & Internal
Gerard A. Kalkman, Cornelis Kramers, Wim van den Brink, Arnt F. A. Schellekens
Article
Substance Abuse
Lisa E. M. Davies, Ellen S. S. Koster, Katinka F. M. Damen, Harmen Beurmanjer, Arnt F. A. Schellekens, Marcel L. L. Bouvy
Summary: In the past decade, prescription opioid use has increased exponentially, leading to a rise in opioid use disorders. This study aimed to understand the patients' perspective on developing a prescription opioid use disorder (OUD). Through in-depth interviews with 25 adults undergoing treatment for prescription OUD, it was found that the development of OUD is influenced by various factors, which can be categorized into three themes: experiences driving initiation, experiences driving continuation, and experiences with prescription OUD. The findings highlight the need for better guidance, monitoring, and pain management strategies to prevent and address prescription OUD.
EUROPEAN ADDICTION RESEARCH
(2023)
