期刊
CEREBRAL CORTEX
卷 24, 期 3, 页码 579-592出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhs330
关键词
axons; blood vessels; encephalopathy of prematurity; periventricular leukomalacia; radial glial fibers; vimentin
资金
- National Institute of Neurological Diseases and Stroke [PO1-NS38475]
- Cerebral Palsy International Research Foundation
- Eunice Shriver Kennedy National Institute of Child Health and Development [R21HD069001, P30-HD018655]
- Biomedical Technology Program of the National Center for Research Resources (NCRR), National Institutes of Health
- NCRR Shared Instrumentation Grant Program [1S10RR023401, 1S10RR019307, 1S10RR023043]
- High-End Instrumentation Grant Program [S10RR016811]
High angular resolution diffusion imaging (HARDI) demonstrates transient radial coherence of telencephalic white matter in the human fetus. Our objective was to define the neuroanatomic basis of this radial coherence through correlative HARDI- and postmortem tissue analyses. Applying immunomarkers to radial glial fibers (RGFs), axons, and blood vessels in 18 cases (19 gestational weeks to 3 postnatal years), we compared their developmental profiles to HARDI tractography in brains of comparable ages (n 11). At midgestation, radial coherence corresponded with the presence of RGFs. At 3031 weeks, the transition from HARDI-defined radial coherence to corticocortical coherence began simultaneously with the transformation of RGFs to astrocytes. By term, both radial coherence and RGFs had disappeared. White matter axons were radial, tangential, and oblique over the second half of gestation, whereas penetrating blood vessels were consistently radial. Thus, radial coherence in the fetal white matter likely reflects a composite of RGFs, penetrating blood vessels, and radial axons of which its transient expression most closely matches that of RGFs. This study provides baseline information for interpreting radial coherence in tractography studies of the preterm brain in the assessment of the encephalopathy of prematurity.
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