Article
Genetics & Heredity
Sathish Venkataramanappa, Dagmar Schuetz, Friederike Saaber, Praveen Ashok Kumar, Philipp Abe, Stefan Schulz, Ralf Stumm
Summary: Mutations in the DONSON gene have been linked to skeletal abnormalities and microcephaly. Deletion of Donson in cortical progenitors led to extensive cell death and abnormalities in cortical development. Targeting Donson may be a potential strategy for experimental and therapeutic purposes.
Review
Neurosciences
Yuki Bando, Masaru Ishibashi, Satoru Yamagishi, Atsuo Fukuda, Kohji Sato
Summary: This review summarizes the functions of ion channels and transporters in neocortical development and discusses the links between channelopathies and neocortical development. Furthermore, it introduces emerging optical techniques for studying neocortical development and the pathophysiology of channelopathies.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Ji-an Wei, Linglin Liu, Xichen Song, Bilian Lin, Jing Cui, Lanzhi Luo, Yuchu Liu, Shihua Li, Xiaojiang Li, Kwok-Fai So, Sen Yan, Li Zhang
Summary: The aggregation of TDP-43 is associated with various neurodegenerative diseases, leading to microglial activation and neuronal loss. This study establishes a mouse model with overexpression of mutant TDP-43, which results in motor-learning deficits. Microglia are observed to approach parvalbumin interneurons, disrupting cortical excitatory-inhibitory balance. Activation of the complement pathway is found to induce microglial activity. Treadmill exercise prevents motor dysfunction by blocking the complement pathway through enhanced release of clusterin. These findings provide new insights into the mechanism of TDP-43-induced cortical deficits and the role of exercise training in disease intervention.
Article
Multidisciplinary Sciences
Matthew T. Schmitz, Kadellyn Sandoval, Christopher P. Chen, Mohammed A. Mostajo-Radji, William W. Seeley, Tomasz J. Nowakowski, Chun Jimmie Ye, Mercedes F. Paredes, Alex A. Pollen
Summary: This study investigates the gene expression trajectories of inhibitory neurons (INs) in primates and mice during neurogenic period. Researchers find that while the initial classes of INs generated prenatally are largely conserved among mammals, there are contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development.
Article
Multidisciplinary Sciences
Brian G. Rash, Jon I. Arellano, Alvaro Duque, Pasko Rakic
Summary: The convolutions of the mammalian cerebral cortex allow for enlargement of its surface and the addition of new functional areas while minimizing expansion of the skull. Neurodevelopmental disorders in humans are often associated with impaired cortical folding. Research suggests that the primary forces driving cortical folding include neuronal growth, formation of neuropil, glial cell intercalation, and the growth of subcortical white matter.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Xiao Liu, Shang-Kun Dai, Pei-Pei Liu, Chang-Mei Liu
Summary: This study demonstrates the important role of Arid1a in regulating the proliferation and differentiation of neural stem/progenitor cells during cortical development, and suggests potential gene candidates for understanding the pathological mechanisms and developing interventions for neurodevelopmental disorders caused by Arid1a mutations. Rescue experiments successfully restored the neurogenic defects in Arid1a knockout neural stem/progenitor cells.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Rachael F. Ryner, Isabel D. Derera, Moritz Armbruster, Anar Kansara, Mary E. Sommer, Antonella Pirone, Farzad Noubary, Michele Jacob, Chris G. Dulla
Summary: Infantile and epileptic spasms syndrome (IESS) is characterized by spasms, abnormal EEG, and epilepsy. The molecular and circuit-level causes of IESS are not well understood. This study found that inhibitory circuit dysfunction occurs in mice with deletions in adenomatous polyposis coli (APC), which may contribute to IESS-related phenotypes.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Robert Kim, Terrence J. Sejnowski
Summary: By analyzing computational models and neural data, the authors demonstrate that inhibitory-to-inhibitory signaling is crucial for maintaining stable temporal dynamics and working memory in the primate prefrontal cortex.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko
Summary: This study investigated the inhibitory effects of GABAA receptors on different types of interneurons in mouse brain slices. The results showed that different types of interneurons have varying sensitivity to inhibition, and GABAA inhibition can decrease the excitability of one type of interneuron while not affecting another type.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Lorenzo Gesuita, Theofanis Karayannis
Summary: The development of neocortical layer 1 is a dynamic process with transient events, including Cajal-Retzius cell death and migration of GABAergic interneurons. These cells, along with diverse axons and dendrites, form an early circuit that undergoes significant changes in structure and function in the adult cortex, emphasizing inhibition. Adult layer 1 becomes a powerful computational platform for the neocortex through the activation of diverse GABAergic inhibitory cells by bottom-up and top-down inputs.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jae-Yeon Kim, Mercedes F. Paredes
Summary: The prolonged developmental timeline of GABAergic interneurons in larger, gyrencephalic animals extends into the early postnatal period, contributing to increased cognitive complexity and flexibility. This delayed integration of interneurons also offers an opportunity for environmental influences to shape neural circuit formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Catherine Fleitas, Pau Marfull-Oromi, Disha Chauhan, Daniel del Toro, Blanca Peguera, Bahira Zammou, Daniel Rocandio, Rudiger Klein, Carme Espinet, Joaquim Egea
Summary: Neuron migration is important in nervous system development, with FLRTs controlling the distribution of cortical inhibitory interneurons through Unc5 receptors, potentially impacting the development of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Minjie Shen, Yu Guo, Qiping Dong, Yu Gao, Michael E. Stockton, Meng Li, Sudharsan Kannan, Tomer Korabelnikov, Keegan A. Schoeller, Carissa L. Sirois, Chen Zhou, Jonathan Le, Daifeng Wang, Qiang Chang, Qian-Quan Sun, Xinyu Zhao
Summary: Parvalbumin interneurons (PVIs) are influenced by the regulation of the FXR1 gene, impacting behaviors and oscillations related to schizophrenia. This reveals a potential mechanism of action for FXR1 in schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Tohar S. Yarden, Adi Mizrahi, Israel Nelken
Summary: This study investigated the role of inhibition in auditory cortex in stimulus-specific adaptation (SSA). Using two-photon targeted cell-attached recordings and optogenetic manipulations, the researchers found that parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing interneurons showed early-onset SSA. Surprisingly, inhibiting PV neurons enhanced responses to deviant stimuli more than to standard stimuli, while inhibiting VIP neurons decreased responses to standard stimuli but not to deviant stimuli.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
G. Dobrzanski, A. Lukomska, R. Zakrzewska, A. Posluszny, D. Kanigowski, J. Urban-Ciecko, M. Liguz-Lecznar, M. Kossut
Summary: In this study, the role of cortical SOM-INs and VIP-INs in a Pavlovian conditioning were examined, revealing the crucial involvement of L4 SOM-INs activity in learning-induced plastic changes. It is suggested that L4 SOM-INs may provide disinhibition by blocking L4 parvalbumin interneurons, allowing information flow into upper cortical layers during learning.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Psychology, Developmental
Sebastien Weibel, Jean-Arthur Micoulaud-Franchi, Laura Brandejsky, Regis Lopez, Paco Prada, Rosetta Nicastro, Stefano Ardu, Alexandre Dayer, Christophe Lancon, Nader Perroud
JOURNAL OF ATTENTION DISORDERS
(2019)
Article
Neurosciences
Thomas Rhomberg, Laura Rovira-Esteban, Attila Vikor, Enrica Paradiso, Christian Kremser, Petra Nagy-Pal, Orsolya I. Papp, Ramon Tasan, Ferenc Erdelyi, Gabor Szabo, Francesco Ferraguti, Norbert Hajos
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Eszter Regos, Hadeer Hesham Abdelfattah, Andrea Reszegi, Laszlo Szilak, Klara Werling, Gabor Szabo, Andras Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornelia Baghy
Review
Cell Biology
Tania Vitalis, Jean Mariani
NEURAL REGENERATION RESEARCH
(2018)
Article
Endocrinology & Metabolism
Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gabor Szabo, Tomas Hokfelt, Tibor Harkany
MOLECULAR METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
Alan Alpar, Peter Zahola, Janos Hanics, Zsofia Hevesi, Solomiia Korchynska, Marco Benevento, Christian Pifl, Gergely Zachar, Jessica Perugini, Ilenia Severi, Patrick Leitgeb, Joanne Bakker, Andras G. Miklosi, Evgenii Tretiakov, Erik Keimpema, Gloria Arque, Ramon O. Tasan, Guenther Sperk, Katarzyna Malenczyk, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Gert Lubec, Miklos Palkovits, Antonio Giordano, Tomas G. M. Hokfelt, Roman A. Romanov, Tamas L. Horvath, Tibor Harkany
Article
Clinical Neurology
Z. Csaba, T. Vitalis, C. Charriaut-Marlangue, I. Margaill, B. Coqueran, P. -L. Leger, I. Parente, A. Jacquens, L. Titomanlio, C. Constans, C. Demene, M. D. Santin, S. Lehericy, N. Perriere, F. Glacial, S. Auvin, M. Tanter, J. -F. Ghersi-Egea, H. Adle-Biassette, J. -F. Aubry, P. Gressens, P. Dournaud
Summary: The impairment of blood-brain barrier is involved in various neurological diseases, and reliable imaging of increased BBB permeability is crucial for research. This study introduces a novel approach based on agonist-induced internalization of neuronal G protein-coupled receptor, providing a simple way to assess BBB dysfunction and development in different conditions.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sivan Subburaju, Sarah Kaye, Yong Kee Choi, Jugajyoti Baruah, Debkanya Datta, Jun Ren, Ashwin Srinivasan Kumar, Gabor Szabo, Dai Fukumura, Rakesh K. Jain, Abdallah Elkhal, Anju Vasudevan
Article
Multidisciplinary Sciences
Quentin Perrenoud, Clemence Leclerc, Helene Geoffroy, Tania Vitalis, Kevin Richetin, Claire Rampon, Thierry Gallopin
Summary: This study compares the electrophysiological and molecular properties of GABAergic interneurons in the hilus and primary sensory cortex of mice. The results suggest that the commonly used features for defining these classes do not have strong discriminative capabilities in the hilus.
Article
Clinical Neurology
Cindy Bokobza, Alice Jacquens, David Guenoun, Blandine Bianco, Anne Galland, Maxime Pispisa, Alexandra Cruz, Manuela Zinni, Valerie Faivre, Anne Roumier, Sophie Lebon, Tania Vitalis, Zsolt Csaba, Tifenn Le Charpentier, Leslie Schwendimann, Pierrette Young-Ten, Vincent Degos, Patricia Monteiro, Pascal Dournaud, Pierre Gressens, Juliette Van Steenwinckel
Summary: Approximately 15 million babies are born prematurely every year, and many of them will face motor and cognitive deficits in their lifetime. Systemic inflammation-induced neuroinflammation is a prominent process of perinatal brain injuries, especially white matter injuries (WMI). Serotonin and its receptors, particularly HTR7, play a significant role in inflammation regulation. The study suggests that targeting HTR7 may serve as an innovative therapeutic strategy to protect the developing brain from preterm brain injuries.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biochemistry & Molecular Biology
Philippe Bonnin, Tania Vitalis, Leslie Schwendimann, Alexandre Boutigny, Nassim Mohamedi, Valerie C. Besson, Christiane Charriaut-Marlangue
Summary: PJ34 treatment in neonatal mice after hypoxic brain injury showed reduced BBB permeability, decreased astrocyte demise, and tissue loss. These results suggest a protective effect of PJ34 on hypoxic brain injury.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Petra Mohacsik, Ferenc Erdelyi, Maria Baranyi, Balint Botz, Gabor Szabo, Monika Toth, Iren Haltrich, Zsuzsanna Helyes, Beata Sperlagh, Zsuzsa Toth, Richard Sinko, Ronald M. Lechan, Antonio C. Bianco, Csaba Fekete, Balazs Gereben
Article
Anatomy & Morphology
Ivan Milenkovic, Tamara Stojanovic, Eleonora Aronica, Livia Fulop, Zsolt Bozso, Zoltan Mate, Yuchio Yanagawa, Homa Adle-Biassette, Gert Lubec, Gabor Szabo, Tibor Harkany, Gabor G. Kovacs, Erik Keimpema
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Cell Biology
Suyan Li, Peeyush T. Kumar, Sampada Joshee, Timo Kirschstein, Sivan Subburaju, Jahan S. Khalili, Jonas Kloepper, Chuang Du, Abdallah Elkhal, Gabor Szabo, Rakesh K. Jain, Ruediger Köhling, Anju Vasudevan
Article
Neurosciences
Tania Vitalis, Luce Dauphinot, Pierre Gressens, Marie-Claude Potier, Jean Mariani, Patricia Gaspar