期刊
CEREBRAL CORTEX
卷 20, 期 6, 页码 1305-1313出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp192
关键词
Alzheimer's disease; clinical subtypes; cognition; longitudinal outcome; morphometry
资金
- National Institutes on Aging [AG031224, K01AG029218]
- National Center for Research Resources [U24 RR021382]
- Department of Veterans Affairs [0007 08-0957]
- University of California, San Diego Stein Institute for Research on Aging
- Alzheimer's Disease Neuroimaging Initiative (ADNI) [AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Pfizer Inc.
- Wyeth Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- GlaxoSmithKline
- Merck Co. Inc.
- AstraZeneca AB
- Novartis Pharmaceuticals Corporation
- Alzheimer's Association
- Eisai Global Clinical Development
- Elan Corporation plc
- Forest Laboratories
- Institute for the Study of Aging
- U.S. Food and Drug Administration
This study aims to investigate the relationship between executive function and verbal memory and to explore the underlying neuroanatomical correlates in 358 individuals with amnestic mild cognitive impairment (MCI) and 222 healthy controls (HCs). The MCI participants were divided into 2 groups (high vs. low) based on executive function task performance. Results demonstrated that although both MCI groups were impaired on all memory measures relative to HCs, MCI individuals with higher executive function (HEF) demonstrated better verbal memory performance than those with lower executive function (LEF), particularly on measures of learning. The 2 MCI groups did not differ in mesial temporal morphometric measures, but the MCI LEF group showed significant thinning in dorsolateral prefrontal and posterior cingulate cortices bilaterally compared with the MCI HEF and HCs. Further, thickness in numerous regions of frontal cortex, and bilateral posterior cingulate, was significantly associated with memory performance in all MCI participants above and beyond the contribution of the mesial temporal regions known to be associated with episodic memory. Overall, these results demonstrate the importance of evaluating executive function in individuals with MCI to predict involvement of brain areas beyond the mesial temporal lobe.
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