Article
Mathematics
Khrystyna Prysyazhnyk, Iryna Bazylevych, Ludmila Mitkova, Iryna Ivanochko
Summary: The study focuses on the homogeneous branching process with migration and continuous time, investigating the distribution of period-life tau and obtaining the probability generating function of the random process. Additionally, the boundary theorem for the period-life of the subcritical or critical branching process with migration was identified.
Review
Oncology
Josephine A. A. Hinneh, Joanna L. L. Gillis, Nicole L. L. Moore, Lisa M. M. Butler, Margaret M. M. Centenera
Summary: Receptor for hyaluronic acid-mediated motility (RHAMM) is a critical cell surface receptor involved in cell migration, cell cycle, and microtubule assembly. It is exploited by tumor cells to promote malignant progression and metastasis. Inhibition of RHAMM can suppress tumor invasiveness and metastatic spread and is considered a potential therapeutic target. However, the complexity of RHAMM's subcellular distribution complicates the design of targeted therapies. Identifying downstream signaling pathways of RHAMM may provide alternative strategies to control tumor aggressiveness.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Caitlin Collins, Sun K. Kim, Rosa Ventrella, Herve M. Carruzzo, Juliana C. Wortman, Hyebin Han, Evelyn E. Suva, Jennifer W. Mitchell, Clare C. Yu, Brian J. Mitchell
Summary: Post-translational modification of tubulin plays a crucial role in regulating the penetrative capacity of cells undergoing radial intercalation. Modulating tubulin acetylation in intercalating cells alters developmental timing, with more acetylation leading to faster penetration. Cells preferentially penetrate higher-order vertices over tricellular vertices, indicating that lower-order vertices are more restrictive sites of insertion. Increasing tubulin acetylation shifts the accessibility of intercalating cells towards more restrictive junctions, as described by a geometric-based mathematical model.
Article
Multidisciplinary Sciences
Duy-Chi Trinh, Marjolaine Martin, Lotte Bald, Alexis Maizel, Christophe Trehin, Olivier Hamant
Summary: In this study, we used a simple plant organ development model to investigate how gene expression variability is managed to maintain organ robustness through mechanical conflicts at the regional scale, affecting the final organ shape.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Anne-Betty Ndiaye, Gijsje H. Koenderink, Michal Shemesh
Summary: The mammalian cytoskeleton plays an important role in transmitting external forces to the cell interior and generating intracellular forces. The three interpenetrating structural proteins, actin, microtubules, and intermediate filaments, have interdependent functions and the intermediate filaments play a central role in mechanosensitivity. Cytoskeletal crosstalk regulates the stability and organization of all three filament families at different scales, and also affects cell adaptation to external cues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xinyi Ren, Xiaopu Guo, Zihan Liang, Renxian Guo, Shaohui Liang, Han Liu
Summary: Cell migration is a complex process that involves the coordination of various cellular components. In this study, we discovered a novel interaction between IQGAP1 and Hax1, which plays a significant role in focal adhesion turnover and directional cell migration. Our findings suggest that Hax1 acts as a link between dynamic focal adhesions and IQGAP1, facilitating efficient cell migration. Perturbation of the IQGAP1/Hax1 interaction impairs focal adhesion turnover and inhibits directional cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Satish Bodakuntla, Hana Nedozralova, Nirakar Basnet, Naoko Mizuno
Summary: Axon branching is a critical process for neural network formation, requiring a local system to dynamically control and regulate axonal growth. Regulation of axon branching involves coordination of cellular functions such as cytoskeleton and membrane remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sadhana Panzade, Maja Matis
Summary: The study shows that the minus-end binding protein Patronin is essential for organizing microtubule arrays in histoblast cells that form the Drosophila abdomen, affecting the function and motility of these cells. Patronin plays a crucial role in mediating epithelium remodeling by regulating the microtubule cytoskeleton.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Aglaja Kopf, Eva Kiermaier
Summary: The organization of microtubule arrays in immune cells is crucial for their effector functions in immune responses. Leukocytes mainly use centrosomes for microtubule nucleation, allowing for plastic MTOC localization and dynamics to adapt to different environmental conditions, highlighting the importance of microtubule involvement in cell shape maintenance and physical coherence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Catia Silva Janota, Andreia Pinto, Anna Pezzarossa, Pedro Machado, Judite Costa, Pedro Campinho, Claudio A. Franco, Edgar R. Gomes
Summary: The endoplasmic reticulum shields immobile ventral stress fibers to establish asymmetric nucleo-cytoskeleton connections with moving dorsal actin cables for nuclear positioning.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Pranay Mandal, Vivek Belapurkar, Deepak Nair, Narendrakumar Ramanan
Summary: The actin-binding protein vinculin plays a critical role in axon growth and neuronal migration, with different functional domains having distinct effects on these processes. The interaction between vinculin and talin is found to be dispensable for axon growth and neuronal migration. Expression of the tail domain of vinculin delays migration, increases branching, and stunts axon growth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Anna Legatova, Marketa Pelantova, Daniel Rosel, Jan Brabek, Aneta Skarkova
Summary: The ability of tumor cells to switch between different invasive modes, known as invasion plasticity, is important for their resistance to targeted treatment. While the role of the actin cytoskeleton in cell invasion is well described, the contribution of microtubules is not yet fully understood. Microtubules play an important role in tumor cell plasticity and can be targeted to affect cell proliferation and invasive properties.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Nuria Ruiz-Reig, Dario Garcia-Sanchez, Olivier Schakman, Philippe Gailly, Fadel Tissir
Summary: Malformation of cortical development (MCD) is a neurodevelopmental disorder characterized by intellectual disability and early-life epileptic seizures. Mutations in genes encoding microtubules (MT) and MT-associated proteins are common causes of MCD. This study found that conditional ablation of KIF2A in forebrain inhibitory neurons led to abnormal behavior and increased susceptibility to epilepsy in mice. KIF2A is crucial for the migration, positioning, and formation of inhibitory synapses of cortical interneurons, shedding light on the mechanism of epilepsy development.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kirstine Lavrsen, Girish Rajendraprasad, Marcin Leda, Susana Eibes, Elisa Vitiello, Vasileios Katopodis, Andrew B. Goryachev, Marin Barisic
Summary: Cell polarization and symmetry breaking are crucial for directed cell migration. The study reveals that microtubule detyrosination drives cell polarization by transporting APC protein to cortical sites through kinesin-1-based transport, supporting the formation of leading edge and directed cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Renping Zhao, Xiangda Zhou, Essak S. Khan, Dalia Alansary, Kim S. Friedmann, Wenjuan Yang, Eva C. Schwarz, Aranzazu del Campo, Markus Hoth, Bin Qu
Summary: The research found that the killing efficiency of cytotoxic T lymphocytes (CTLs) is significantly impaired in dense collagen matrices, while disrupting the microtubule network can significantly increase CTL migration, search efficiency, and killing efficiency in dense collagen.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Genetics & Heredity
Adam J. Kundishora, Benjamin C. Reeves, Carol Nelson-Williams, Christopher S. Hong, Pallavi P. Gopal, Matija Snuderl, Kristopher T. Kahle, E. Zeynep Erson-Omay
Article
Clinical Neurology
Alexander C. Mamourian, Pallavi Gopal, Karapet Davtyan, Michael Kaiserian, Elizabeth C. Mamourian, Brad E. Zacharia
WORLD NEUROSURGERY
(2020)
Article
Biochemistry & Molecular Biology
Xiuyu Shi, Wenbo Lin, Xiang Gao, Wen Xie, Jeffrey A. Golden, Tao Tao
BIOSCIENCE REPORTS
(2020)
Article
Clinical Neurology
Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa, Tao Tao, Jeffrey A. Golden
ANNALS OF NEUROLOGY
(2020)
Article
Medicine, General & Internal
Kun-Hsing Yu, Vincent Hu, Feiran Wang, Ursula A. Matulonis, George L. Mutter, Jeffrey A. Golden, Isaac S. Kohane
Article
Oncology
Christopher S. Hong, Greg Fliney, Adeniyi Fisayo, Yi An, Pallavi P. Gopal, Antonio Omuro, Renelle Pointdujour-Lim, E. Zeynep Erson-Omay, S. Bulent Omay
Summary: Optic nerve glioma is a rare tumor that mainly affects children and is associated with neurofibromatosis type 1 syndrome. Although adult cases may occur, clinical behavior may be more aggressive, highlighting the need for further research and guidance on treatment strategies.
BRAIN TUMOR PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shavanie Prashad, Pallavi P. Gopal
Summary: RNA-binding proteins play a critical role in regulating various aspects of gene expression, and aberrant RNA metabolism is a common pathogenic mechanism in multiple neurological diseases. Studying disease-linked RNA-binding proteins helps to understand the pathogenesis of neurological disorders.
Article
Multidisciplinary Sciences
Marta Olah, Vilas Menon, Naomi Habib, Mariko F. Taga, Yiyi Ma, Christina J. Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Gruen, Alexandra A. Kroshilina, Danielle Dionne, Rani A. Sarkis, Garth R. Cosgrove, Jeffrey Helgager, Jeffrey A. Golden, Page B. Pennell, Marco Prinz, Jean Paul G. Vonsattel, Andrew F. Teich, Julie A. Schneider, David A. Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M. Bradshaw, Philip L. De Jager
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Eliana Marostica, Rebecca Barber, Thomas Denize, Isaac S. Kohane, Sabina Signoretti, Jeffrey A. Golden, Kun-Hsing Yu
Summary: The study demonstrates that convolutional neural networks can accurately diagnose renal cancers, predict patients' genomic profiles and prognosis, and identify genomic variations, showcasing the potential for integrating diverse data modalities in clinical research.
CLINICAL CANCER RESEARCH
(2021)
Article
Pathology
Anthony T. Yachnis, Jeffrey A. Golden
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2022)
Editorial Material
Genetics & Heredity
Deepika D'Cunha Burkardt, Pedro A. Sanchez-Lara, Katta M. Girisha, Jeffrey A. Golden, John C. Carey
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Endocrinology & Metabolism
Christopher S. Hong, Aladine A. Elsamadicy, Adeniyi Fisayo, Silvio E. Inzucchi, Pallavi P. Gopal, Eugenia M. Vining, E. Zeynep Erson-Omay, Sacit Bulent Omay
Summary: Granular cell tumors of the pituitary are rare neoplasms arising from the posterior pituitary gland. While considered benign, their resection can lead to poor clinical outcomes. Whole-exome sequencing revealed mutations in key oncogenes SETD2 and PAX8, potentially enabling targeted therapies with approved drugs. This represents the first comprehensive genomic characterization of granular cell tumors of the posterior pituitary gland and may lead to further investigation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Yasha Ektefaie, William Yuan, Deborah A. Dillon, Nancy U. Lin, Jeffrey A. Golden, Isaac S. Kohane, Kun-Hsing Yu
Summary: This study developed deep learning models to examine the connections between visual morphological signals in breast cancer and genetic statuses, achieving strong predictive performance in clinical subtyping and gene expression analysis.
Article
Developmental Biology
Youngshin Lim, Il-Taeg Cho, Jeffrey A. Golden, Ginam Cho
Summary: The ARX gene is crucial for brain development, and mutations can lead to neurodevelopmental disorders. Mouse models have provided insights into the pathophysiology of these disorders. The FLAG-Arx mouse line is a valuable tool for isolating ARX complexes.
Article
Cell Biology
Sonali S. Vishal, Denethi Wijegunawardana, Muthu Raj Salaikumaran, Pallavi P. Gopal
Summary: This study identifies key structural elements, including the alpha-helical domain, phenylalanine residues within the LARKS, and the RGG motif, that are crucial for TDP-43 RNP transport and condensate formation in neurons. These findings suggest that these structural elements may mediate efficient recruitment of motors and adaptor proteins, and offer a possible mechanism underlying ALS-linked TDP-43 defects in axonal transport and homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)