Article
Neurosciences
Cindy H. Lee, Kristi L. Bartholomay, Matthew J. Marzelli, Jonas G. Miller, Jennifer L. Bruno, Amy A. Lightbody, Allan L. Reiss
Summary: This study investigated neuroanatomical differences in young females with fragile X syndrome compared to a matched control group. The results showed larger total gray and white matter volumes in girls with fragile X syndrome, as well as differences in specific brain regions. These findings provide insights into the gene-brain-behavior relationships underlying the fragile X syndrome phenotype in females and expand our understanding of the neurodevelopmental mechanisms in this condition.
Article
Neurosciences
Feng Sang, Yaojing Chen, Kewei Chen, Mingxi Dang, Shudan Gao, Zhanjun Zhang
Summary: The study found that both male and female brains show age-related decreases in gray and white matter volumes, with females experiencing a greater volume reduction. Additionally, stronger associations between brain structures and cognition were identified in males compared to females.
Article
Multidisciplinary Sciences
Sergio Leonardo Mendes, Walter Hugo Lopez Pinaya, Pedro Mario Pan, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan, Joao Ricardo Sato
Summary: Recently, studies have investigated the neurodevelopment of psychiatric disorders using structural magnetic resonance imaging (sMRI) data. This study explores the reliability and consistency of a model trained on different datasets with varying stages of neurodevelopment and mental health conditions. The models used 3D convolutional neural networks (CNN) to assess autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), brain age, and dimensional psychopathology. Despite demographic and phenotypic differences, the models showed significant age estimations within and between datasets, with moderate to high correlation. The findings provide insights into youth neurodevelopmental structural changes and highlight the importance of less confounded training datasets for model generalization.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Aliyah Allick, Grace Park, Kwon Kim, Michelle Vintimilla, Krutika Rathod, Rachael Lebo, Julie Nanavati, Christopher J. Hammond
Summary: Investigating gray matter volume differences between adolescent cannabis users and typically developing youth, it was found that these differences may vary subtly and depend on age, cumulative cannabis exposure, and sex, indicating potential complexity in the relationship.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pediatrics
Hui Wang, Zeng-Hui Ma, Ling-Zi Xu, Liu Yang, Zhao-Zheng Ji, Xin-Zhou Tang, Jing-Ran Liu, Xue Li, Qing-Jiu Cao, Jing Liu
Summary: This study found that individuals with autism spectrum disorder showed different atypical regional gray matter volumetric changes in childhood, adolescence, and adulthood compared to their typically developing peers, highlighting the importance of considering developmental stages of the brain when exploring brain structural atypicalities in autism.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Article
Psychology, Clinical
KangCheng Wang, YuFei Hu, ChaoGan Yan, MeiLing Li, YanJing Wu, Jiang Qiu, XingXing Zhu
Summary: This study investigated the brain morphology of depressed patients using voxel-based morphometry (VBM) and source-based morphometry (SBM) methods, and identified differences between first-episode and recurrent patients. These findings offer a promising multivariate approach for identifying potential neurobiological markers for depression.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Sally C. Chester, Tatsuyoshi Ogawa, Maki Terao, Ryusuke Nakai, Nobuhito Abe, Stephane A. De Brito
Summary: This study investigated the neuroanatomical correlates of psychopathic traits in a Japanese sample using structural magnetic resonance imaging data. The results showed associations between psychopathic traits and gray matter volume as well as gyrification in specific brain regions. The associations varied based on sex and different levels of psychopathy factors.
Article
Neurosciences
Yashar Zeighami, Mahsa Dadar, Justine Daoust, Melissa Pelletier, Laurent Biertho, Leonie Bouvet-Bouchard, Stephanie Fulton, Andre Tchernof, Alain Dagher, Denis Richard, Alan Evans, Andreanne Michaud
Summary: Individuals with obesity tend to have increased brain age due to poor brain health caused by grey and white matter atrophy. Weight loss and cardiometabolic improvements following bariatric surgery may reverse this condition and improve brain health.
Article
Neurosciences
David Andre Barriere, Arsene Ella, Frederic Szeremeta, Hans Adriaensen, William Meme, Elodie Chaillou, Martine Migaud, Sandra Meme, Frederic Levy, Matthieu Keller
Summary: Using new MRI resources, transient hypertrophies were observed in various brain regions of female mice during gestation and lactation. Highly maternal females exhibited different brain modifications compared to females with lower levels of maternal care.
Article
Psychology, Biological
Gokhan Aydogan, Remi Daviet, Richard Karlsson Linner, Todd A. Hare, Joseph W. Kable, Henry R. Kranzler, Reagan R. Wetherill, Christian C. Ruff, Philipp D. Koellinger, Gideon Nave
Summary: The study investigates the association between polygenic risk scores for risky behavior and variations in grey-matter volume across multiple brain areas, finding that this relationship accounts for approximately 2.2% of the association between genes and behavior.
NATURE HUMAN BEHAVIOUR
(2021)
Review
Clinical Neurology
Haiyang Yu, Duanyong Chen, Hai Jiang, Guangtao Fu, Yuhui Yang, Zhantao Deng, Yuanfeng Chen, Qiujian Zheng
Summary: Spinal cord injury (SCI) can cause changes in brain structure and function. A voxel-based meta-analysis was conducted to identify specific changes in brain gray matter volume (GMV) and white matter volume (WMV) following SCI. The results showed significant GMV loss in the left insula and bilateral thalamus, as well as significant WMV loss in the bilateral corticospinal tract (CST) in SCI patients compared to healthy controls. Higher motor and pinprick scores were associated with greater GMV in the right postcentral gyrus, while a positive relationship was observed between the light touch score and the bilateral postcentral gyrus. These findings suggest that SCI may trigger neurodegeneration changes in the sensory and motor pathways, and that atrophy of the left insula may be related to depression and neuropathic pain in SCI patients. These structural abnormalities could serve as neuroimaging biomarkers for evaluating prognosis and treatment effect, as well as monitoring disease progression.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Clinical
Stuart B. Murray, Joel P. Diaz-Fong, Christina J. Duval, Ane A. Balkchyan, Jason M. Nagata, Darrin J. Lee, Kyle T. Ganson, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: This study found regional sex differences in terms of gray matter morphometry in early-onset binge eating disorder (BED), with girls showing higher gray matter density.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Tomoyo Morita, Minoru Asada, Eiichi Naito
Summary: The study found that concerns about being evaluated by others, a trait related to public self-consciousness, were associated with gray matter expansions in emotion-related regions and default mode networks in the brain, while there was no relationship observed between gray matter volume and private self-consciousness scores.
Review
Psychiatry
Carolin Spindler, Louisa Mallien, Sebastian Trautmann, Nina Alexander, Markus Muehlhan
Summary: White matter (WM) alterations are significant in patients with alcohol use disorder (AUD), and these changes may contribute to motor, cognitive, affective, and perceptual impairments. However, further research is needed to understand the variations of WM alterations over the course of the disorder and their reversibility with prolonged abstinence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Hiroki Tanaka, Qiulu Shou, Toko Kiyonari, Tetsuya Matsuda, Masamichi Sakagami, Haruto Takagishi
Summary: The study suggests that gray matter volume in the dorsolateral prefrontal cortex is associated with prosocial behavior, but the direction of this relationship is controversial. The concept of default prosociality preference moderates this relationship.
Article
Psychiatry
Akiko Kanehara, Haruna Koike, Yumiko Fujieda, Sayaka Yajima, Asami Kabumoto, Yousuke Kumakura, Kentaro Morita, Yuki Miyamoto, Masahiro Nochi, Kiyoto Kasai
Summary: The study explores how individuals using mental health services in Japan perceive personal recovery and identifies compassion for others, rebuilding/redefining identity, and positive childhood experiences as key factors promoting recovery. The findings suggest that cultural values play a significant role in shaping identities and personal values, ultimately impacting the process of personal recovery.
Article
Clinical Neurology
Junya Matsumoto, Kenichiro Miura, Masaki Fukunaga, Kiyotaka Nemoto, Daisuke Koshiyama, Naohiro Okada, Kentaro Morita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satsuki Ito, Naomi Hasegawa, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: Patients with schizophrenia may experience intelligence decline, and previous studies have suggested that gray matter structures and functional connectivity are more relevant to this decline than white matter microstructures.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Review
Clinical Neurology
Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
Summary: The underlying pathologies of psychiatric disorders are still unknown, causing significant personal and social losses. Conducting large-sample-size research and collaborative research across various fields can help clarify the core pathological mechanisms underlying psychiatric disorders and contribute to the development of young researchers.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Daniel Stanyon, Syudo Yamasaki, Shuntaro Ando, Kaori Endo, Miharu Nakanishi, Tomoki Kiyono, Mariko Hosozawa, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: Autistic traits are associated with psychotic experiences in adolescence, and bullying victimization may mediate this association. Prevention of bullying victimization may help reduce the risk of psychosis among adolescents with autistic traits.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Kaori Endo, Syudo Yamasaki, Miharu Nakanishi, Jordan DeVylder, Satoshi Usami, Yuko Morimoto, Daniel Stanyon, Kazuhiro Suzuki, Mitsuhiro Miyashita, Makoto Arai, Shinya Fujikawa, Sho Kanata, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the longitudinal association between psychotic experiences and loneliness among adolescents. The results showed a significant positive association between psychotic experiences and subsequent loneliness, suggesting that loneliness could be a sign of underlying psychotic experiences in young adolescents. However, the reverse association, between preceding loneliness and later psychotic experiences, was not significant.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Ai Aoki, Ganchimeg Togoobaatar, Anudari Tseveenjav, Naranbaatar Nyam, Khishigsuren Zuunnast, Gundegmaa Lkhagvasuren, Bat-Erdene Shagdar, Rintaro Mori, Akihito Kikuchi, Hideaki Soya, Kiyoto Kasai, Kenji Takehara
Summary: This study examined the association between socioeconomic and lifestyle factors with mental health problems among school-age children in Mongolia. The results showed that male gender, low maternal education, short sleep, lack of physical activity, and long screen time were associated with a higher risk of mental health problems. The findings suggest the presence of globally common socioeconomic and lifestyle risk factors, and may help in developing targeted preventive interventions for high-risk groups and promoting a healthy lifestyle in Mongolia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Neurosciences
Miharu Nakanishi, Syudo Yamasaki, Shuntaro Ando, Kaori Endo, Marcus Richards, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the association between neighborhood social cohesion and dementia-related stigma and found that greater neighborhood social cohesion was associated with lower personal and perceived public stigma. However, there was no difference in stigma levels between the pre-pandemic and pandemic periods.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Kaori Usui, Kenji Kirihara, Mariko Tada, Mao Fujioka, Daisuke Koshiyama, Motoko Tani, Maiko Tsuchiya, Susumu Morita, Shintaro Kawakami, Akiko Kanehara, Kentaro Morita, Yoshihiro Satomura, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai
Summary: This study examines the association between longitudinal changes in clinical symptoms and quality of life in individuals with ultra-high risk for psychosis and patients with recent-onset psychotic disorder. The results indicate that severe anxiety/depression at baseline is associated with poorer quality of life at follow-up. Improvement in anxiety/depression and disorganized thoughts is important for enhancing quality of life. The study also suggests that the diagnosis does not affect the association between clinical symptoms and quality of life.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Yinghan Zhu, Hironori Nakatani, Walid Yassin, Norihide Maikusa, Naohiro Okada, Akira Kunimatsu, Osamu Abe, Hitoshi Kuwabara, Hidenori Yamasue, Kiyoto Kasai, Kazuo Okanoya, Shinsuke Koike
Summary: The study showed that machine learning approaches using structural MRI can help with disease classification, with a classifier accurately distinguishing patients with chronic schizophrenia from healthy controls. Individuals within the schizophrenia spectrum were more likely to be classified as having chronic schizophrenia, with individuals on the autism spectrum least likely to be classified in the same category.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, General & Internal
Miharu Nakanishi, Syudo Yamasaki, Junko Niimura, Kaori Endo, Naomi Nakajima, Daniel Stanyon, Kaori Baba, Nao Oikawa, Mariko Hosozawa, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: The study found an association between maternal perceived capacity in finance and mental well-being and the frequency of physical punishment in 14-year-old children. Increasing mothers' perceived capacity in financial management and mental health may help prevent child maltreatment.
Article
Psychiatry
Kaori Endo, Daniel Stanyon, Syudo Yamasaki, Miharu Nakanishi, Junko Niimura, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Mariko Hosozawa, Kaori Baba, Nao Oikawa, Naomi Nakajima, Kazuhiro Suzuki, Mitsuhiro Miyashita, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the longitudinal association between maternal parenting stress from 1 to 36 months after childbirth and child ADHD symptoms at 12 years old. The results showed that parenting stress at 9-10, 18, and 36 months after childbirth was significantly associated with child ADHD symptoms at 12 years old.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka
Summary: This study investigates the communication between the frontal and temporal cortices in an auditory omission paradigm, finding an increased band synchronization between the higher auditory cortex and the frontal pole at tone onset, but a disappearance of this synchronization when the tone is omitted. An early omission-related neural response was observed, along with stronger low-beta oscillations following tone omission.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Kiyoto Kasai, Shin-Ichiro Kumagaya, Yusuke Takahashi, Yutaka Sawai, Akito Uno, Yousuke Kumakura, Mika Yamagishi, Akiko Kanehara, Kentaro Morita, Mariko Tada, Yoshihiro Satomura, Naohiro Okada, Shinsuke Koike, Sho Yagishita
Summary: By nature, humans are participating subjects/player-witnesses who encounter an unpredictable real world. We propose incorporating the interaction loop into cognitive sciences to create world-informed neuroscience (WIN). Based on research with people who do not match the world, we hypothesize that the interaction between individuals and the world occurs in a two-dimensional way of rule-based and story-based. Integrating the humanities and sciences, this approach can contribute to real world issues and diversity and inclusion.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Psychiatry
Junko Niimura, Miharu Nakanishi, Syudo Yamasaki, Shuntaro Ando, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Kaori Endo, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the association between parenting stress, maternal depressive symptoms, and use of physical punishment when the child is 10 years old. The results showed that maternal parenting stress experienced at 1 and 36 months after birth predicted the use of physical punishment, even after adjusting for maternal depressive symptoms. Therefore, maternal support should be provided to cope with parenting stress and prevent the use of physical punishment in early adolescence.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S. Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F. Bartholomeusz, Michael W. L. Chee, Tiziano Colibazzi, Rebecca E. Cooper, Cheryl M. Corcoran, Vanessa L. Cropley, Bjorn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj, Holly K. Hamilton, Kristen M. Haut, Rebecca A. Hayes, Ying He, Karsten Heekeren, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Shinsuke Koike, Alex Koppel, Tina D. Kristensen, Yoo Bin Kwak, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Ashleigh Lin, Rachel L. Loewy, Daniel H. Mathalon, Chantal Michel, Romina Mizrahi, Paul Moller, Barnaby Nelson, Takahiro Nemoto, Dorte Nordholm, Maria A. Omelchenko, Christos Pantelis, Jayachandra M. Raghava, Jan Rossberg, Wulf Roessler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K. Tamnes, Jinsong Tang, Anastasia Theodoridou, Sophia Thomopoulos, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Vaernes, Therese A. M. J. van Amelsvoort, Theo G. M. Van Erp, James A. Waltz, Lars T. Westlye, Stephen J. Wood, Juan H. Zhou, Philip McGuire, Paul M. Thompson, Maria Jalbrzikowski, Dennis Hernaus, Paolo Fusar-Poli
Summary: Individuals at Clinical High Risk for Psychosis (CHR-P) show heterogeneity in neuroanatomical profiles, with significant differences in cortical surface area, cortical thickness, and subcortical volume compared to healthy controls. However, these profiles are not associated with the subsequent transition to psychosis.
TRANSLATIONAL PSYCHIATRY
(2022)