期刊
CEREBRAL CORTEX
卷 19, 期 6, 页码 1313-1321出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhn170
关键词
information processing; population vector; prefrontal cortex; rhesus monkey; thalamus; working memory
资金
- Japanese Ministry of Education, Science, Sports, Culture, and Technology [18020016, 14380367, 17300103, 18730481]
- 21st Century COE Program (D-2 to Kyoto University), MEXT, Japan
To understand functional roles of the thalamic mediodorsal nucleus (MD) in sensory-to-motor information transformation during spatial working memory performance and compare with those of the dorsolateral prefrontal cortex (DLPFC), we calculated population vectors using a population of MD activities recorded during 2 tasks. In the oculomotor delayed-response (ODR) task, monkeys needed to make a memory-guided saccade to the cue location, whereas in the rotatory oculomotor delayed-response (R-ODR) task, they needed to make a memory-guided saccade 90(o) clockwise from the cue direction. The directions of population vectors calculated from populations of cue- and response-period activities were similar to the cue and saccade target directions, respectively, which confirmed that population vectors represent information regarding the directions of the visual cue and the saccade target. We then calculated population vectors of delay-period activity using a sliding 250-ms time window. In the ODR task, population vectors were directed toward the cue direction throughout the delay. However, in the R-ODR task, they gradually rotated from the cue direction to the saccade target direction. Based on a comparison with the results obtained from DLPFC neurons, the rotation of population vectors started earlier in the MD than in the DLPFC, suggesting that the motor information regarding forthcoming saccade is provided from the MD.
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