Article
Neurosciences
Silvia Basaia, Federica Agosta, Alessandro Francia, Camilla Cividini, Roberta Balestrino, Tanja Stojkovic, Iva Stankovic, Vladana Markovic, Elisabetta Sarasso, Andrea Gardoni, Rosita De Micco, Luigi Albano, Elka Stefanova, Vladimir S. Kostic, Massimo Filippi
Summary: This study investigates functional alterations within the cerebro-cerebellar system in different motor subtypes of Parkinson's disease (PD) and identifies neuroimaging features that predict conversion between subtypes. The results reveal distinct functional connectivity patterns between tremor-dominant and postural-instability-and-gait-disorder subtypes. Additionally, combining clinical and functional connectivity data improves the ability to identify subtype conversion.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Wei Xu, Felipe De Carvalho, Andrew Jackson
Summary: This study used wireless recording to examine the relationship between neural activity in the cerebro-cerebellar system during waking behavior and natural sleep. The results showed similarities in firing patterns between movements during waking and sleep, as well as preserved sequential firing in both states. However, there was a global change in the timing of cerebellar activity relative to motor cortex during sleep.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Li -Da Su, Fang-Xiao Xu, Xin-Tai Wang, Xin-Yu Cai, Ying Shen
Summary: The cerebellum is not only involved in motor learning and coordination, but also plays a role in cognition and emotion behaviors. It is recognized as a key brain region affected in autism spectrum disorder. Future studies need to investigate the role of cerebellar dysfunction, cerebro-cerebellar connectivity, and ASD.
Article
Behavioral Sciences
L. Danesin, M. Oliveri, C. Semenza, G. Bottini, F. Burgio, A. Giustiniani
Summary: Neuroimaging studies have indicated that prism adaptation for neglect rehabilitation involves different brain regions, including the parietal cortex and the cerebellum. The parietal cortex is involved in conscious compensatory mechanisms during the initial stage, while the cerebellum aids in sensory error prediction and internal model update in later stages. Previous studies have examined the effects of lesions in either the parietal cortex or the cerebellum, but no comparisons between the two have been made. In this study, digital prism adaptation was used to test visuomotor learning differences in a patient with parietal lesion and a patient with cerebellar lesion. The results showed significant differences in the performance of the parietal lesion patient compared to healthy controls and the cerebellar lesion patient, while no differences were observed between the cerebellar lesion patient and healthy controls.
Article
Neurosciences
Monica Christova, Victoria Sylwester, Eugen Gallasch, Shane Fresnoza
Summary: This study explored the effects of peripherally applied vibrotactile stimuli on cerebello-cortical functional connections. The results showed that hand stimulation led to a reduction in cerebellar brain inhibition and increased vibration perception threshold, indicating functional connections between the cerebellum and primary motor cortex, and suggesting that the cerebellum influences the processing of vibrotactile stimulus through motor-sensory interactions.
Review
Neurosciences
Ellen Boven, Nadia L. Cerminara
Summary: Research suggests that the cerebellum is involved not only in sub-second time processing, but also in supra-second time processing. The reciprocal loops between the cerebellum and cerebral cortex play a role in modulating cerebral processing during complex sequence learning. The cerebellum's intrinsic ability to support millisecond timescales may be complemented by its interactions with other brain regions, such as the prefrontal cortex, to support supra-second timescales.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel
Summary: The study found that multisession motorcortical stimulation is beneficial for skill acquisition, while monofocal cerebellar stimulation or sequential multifocal motorcortico-cerebellar stimulation did not show additional effects. Baseline task performance and structural integrity of the bilateral superior cerebellar peduncle are the most influential predictors of training success.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Georgios D. Argyropoulos, Foteini Christidi, Efstratios Karavasilis, Georgios Velonakis, Anastasia Antoniou, Peter Bede, Ioannis Seimenis, Nikolaos Kelekis, Athanasios Douzenis, Olympia Papakonstantinou, Efstathios Efstathopoulos, Panagiotis Ferentinos
Summary: This study found alterations in fronto-ponto-cerebellar connectivity in euthymic BD patients and distinctive cerebro-cerebellar white matter signatures in polarity-related subphenotypes, highlighting potential clinical and pathobiological implications.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Ehsan Sedaghat-Nejad, Jay S. Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmehr
Summary: The ability of the brain to control movement accurately relies on the cerebellum. Recent research has found that cerebellar P cells transmit information by synchronizing their spikes and utilizing disinhibition to convey important signals for movement control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neuroimaging
Sharon Geva, Letitia M. Schneider, Sophie Roberts, Shamima Khan, Andrea Gajardo-Vidal, Diego L. Lorca-Puls, Thomas M. H. Hope, David W. Green, Cathy J. Price
Summary: Research showed that patients with damage to cerebellar speech production regions exhibited greater activation in cerebral motor speech areas during a range of speech production tasks compared to neurologically intact controls. These findings may drive future studies to delineate functional contributions of different parts of the speech production network and assess the potential of non-invasive stimulation to facilitate speech recovery.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Jussi Alho, John G. Samuelsson, Sheraz Khan, Fahimeh Mamashli, Hari Bharadwaj, Ainsley Losh, Nicole M. Mcguiggan, Steven Graham, Zein Nayal, Tyler K. Perrachione, Robert M. Joseph, Catherine J. Stoodley, Matti S. Hamalainen, Tal Kenet
Summary: This study investigates the impact of cerebellar differences on language processing in individuals with Autism Spectrum Disorder (ASD). Through the use of magnetoencephalography (MEG), brain activity was recorded while ASD children and typically developing children processed meaningful and meaningless sentences. The results reveal atypical functional connectivity patterns in the cerebellum of ASD children, suggesting a link between aberrant stimulus-driven attention and ASD severity.
HUMAN BRAIN MAPPING
(2023)
Review
Behavioral Sciences
Libera Siciliano, Giusy Olivito, Maria Leggio
Summary: This review examines the volumetric and functional changes in the cerebellum of individuals with eating disorders (EDs) and proposes that the cerebellum plays a critical role in the pathophysiology of EDs, requiring further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neuroimaging
Joana R. A. Loureiro, Ashish K. Sahib, Megha Vasavada, Amber Leaver, Antoni Kubicki, Benjamin Wade, Shantanu Joshi, Gerhard Hellemann, Eliza Congdon, Roger P. Woods, Randall Espinoza, Katherine L. Narr
Summary: Patients with major depressive disorder (MDD) show impaired cognitive and emotional control, attributed to abnormal communication between cortical networks and altered communication with the cerebellum. This study found significant changes in cerebro-cerebellar circuitry during response-inhibition with ketamine treatment, highlighting potential biomarkers for fast-acting antidepressant therapies.
NEUROIMAGE-CLINICAL
(2021)
Review
Neurosciences
Chun-Hwei Tai, Sheng-Hong Tseng
Summary: Deep brain stimulation (DBS) is an effective treatment for various movement disorders, but some disorders do not respond well to current DBS therapy. Recent studies have suggested that cerebellar DBS may be beneficial for these non-responsive movement disorders. This article reviews the clinical data of cerebellar DBS, including indications, surgical targets, programming details, and outcomes, and discusses the potential mechanism of action. The study of new DBS targets in the cerebellum is important for a comprehensive treatment of movement disorders.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Psychiatry
Sung Eun Kim, Sungcheol Jung, Gyhye Sung, Minji Bang, Sang-Hyuk Lee
Summary: Schizophrenia is a complex brain disorder with unknown etiology. This study aimed to investigate structural white matter connectivity in the cerebellum and its association with cognitive dysfunction in schizophrenia patients. The results showed that aberrations in cerebellar white matter connectivity were linked to poorer cognitive performance in patients with schizophrenia, providing insights into the neurobiology of the disorder.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sayo Otani, Yasutaka Fushimi, Kogoro Iwanaga, Seiichi Tomotaki, Yusuke Yokota, Sonoko Oshima, Azusa Sakurama, Krishna Pandu Wicaksono, Takuya Hinoda, Akihiko Sakata, Satoshi Nakajima, Tomohisa Okada, Junko Takita, Masahiko Kawai, Kaori Togashi
Summary: In this study of 102 neonates, the signal intensity and volume of the pituitary and thyroid glands on MRI were found to be positively correlated with gestational age and birth weight, while negatively correlated with chronological age.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Eri Nakagawa, Motofumi Sumiya, Takahiko Koike, Norihiro Sadato
Summary: The study found that praise enhances motor performance, and feedback of acceptance or rejection activates different brain areas. Social signals can influence the early visual cortex and affect the motor control system through this process.
Article
Clinical Neurology
Akihiko Sakata, Yasutaka Fushimi, Tomohisa Okada, Satoshi Nakajima, Takuya Hinoda, Peter Speier, Michaela Schmidt, Christoph Forman, Kazumichi Yoshida, Hiroharu Kataoka, Susumu Miyamoto, Yuji Nakamoto
Summary: The diagnostic performance of compressed sensing (CS)-TOF-MRA is comparable to that of conventional parallel imaging (PI)-TOF-MRA in detecting and classifying arteriovenous shunts (AVS), with a reduced scan time under 2.5 minutes.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Okada, Thai Akasaka
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Ayumi Yoshioka, Hiroki C. Tanabe, Motofumi Sumiya, Eri Nakagawa, Shuntaro Okazaki, Takahiko Koike, Norihiro Sadato
Summary: The study found that sharing visual experience is mediated by joint attention and mentalizing. Neuro synchronization of task-specific activities occurred in specific brain regions during joint attention tasks. Additionally, there was inter-individual synchronization of residual time-series data in the right AIC-IFG, representing the belief of sharing the situation.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Okada, Shinya Handa, Bill Ding, Shin-ichi Urayama, Koji Fujimoto, Atsushi Shima, Daisuke Yoshii, Takashi Ayaki, Nobukatsu Sawamoto, Ryosuke Takahashi, Hirotaka Onoe, Tadashi Isa, Labros Petropoulos
Summary: The study aimed to demonstrate the capability of insertable inductively coupled volumetric coils in a human 7T MR system for MR microscopy. Results showed that the insertable coils provided high SNR and modest parallel imaging capability, successfully visualizing fine structures of brain specimens. These coils are easy to handle and enable MR microscopy in a human whole-body 7T MRI system.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Behavioral Sciences
Maho Hashiguchi, Takahiko Koike, Tomoyo Morita, Tokiko Harada, Denis Le Bihan, Norihiro Sadato
Summary: The perception and cognitive interpretation of time duration is subjective and connected with arousal and interoceptive signals. This study found that the insula, a critical brain region for integrating information from the external world with the organism's inner state, plays a central role in the perception of time duration and contributes to its estimation accuracy. The results also showed that the right anterior insular cortex and inferior frontal gyrus are involved in the accurate perception of temporal duration.
Article
Behavioral Sciences
Tagiru Nakamura, Tomoko Matsui, Akira Utsumi, Motofumi Sumiya, Eri Nakagawa, Norihiro Sadato
Summary: During conversation, sarcasm is perceived as an incongruity between the context, content, and prosody of the utterance. This study found that prosody modifies the effect of context-content incongruity in sarcasm comprehension. Neuroimaging results revealed the involvement of various brain regions, including the cerebellum, amygdala, and dorsolateral prefrontal cortex, in processing sarcasm and its incongruities.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Thai Akasaka, Tomohisa Okada
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Yoshihisa Nakayama, Sho K. Sugawara, Masaki Fukunaga, Yuki H. Hamano, Norihiro Sadato, Yukio Nishimura
Summary: This study found that different portions of the dorsal premotor cortex are activated during the step-by-step planning processes for visually guided goal-directed motor behavior, forming functional subregions and a gradient.
Article
Anatomy & Morphology
Chieko Matsunari, Toru Kanahashi, Hiroki Otani, Hirohiko Imai, Shigehito Yamada, Tomohisa Okada, Tetsuya Takakuwa
Summary: This study analyzes and comprehensively understands the morphogenesis of the fetal tentorium cerebelli (TC) and brain, and finds that their morphologies influence each other during development. The study provides important insights into the formation of TC at different stages of development.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Neurosciences
Ayumi Yoshioka, Hiroki C. C. Tanabe, Eri Nakagawa, Motofumi Sumiya, Takahiko Koike, Norihiro Sadato
Summary: Conversation allows us to share our subjective experiences by expressing our thoughts and feelings. The interaction between the mentalizing network and the mirror neuron system (MNS) mediates the exchange of introspection during a conversation. This study used functional magnetic resonance imaging to investigate the neural mechanisms involved in real-time conversations.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hayaru Shouno, Tomohisa Okada
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tetsuya Yamamoto, Tomohisa Okada
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Tomohisa Okada, Hideto Kuribayashi, Yuta Urushibata, Koji Fujimoto, Thai Akasaka, Ravi Teja Seethamraju, Sinyeob Ahn, Tadashi Isa
Summary: This study investigates the effects of measured macromolecules (MMs) basis and DKNTMN parameter on neurochemical quantification. The results show that using a measured basis and setting DKNTMN to 0.30 in LCModel analysis yields the best results and is recommended for neurochemical quantification.
