The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia

Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model

(2013) Andrea H. Németh et al.   BRAIN

TRPC3 Channel Underlies Cerebellar Long-Term Depression

(2013) Sang Jeong Kim   CEREBELLUM

Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias

(2013) A. Matilla-Dueñas et al.   CEREBELLUM

Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells

(2013) Ayumu Konno et al.   CEREBELLUM

Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors

(2013) Visou Ady et al.   EMBO REPORTS

Conserved Gating Elements in TRPC4 and TRPC5 Channels

(2013) Andreas Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Homozygous Deletion in GRID2 Causes a Human Phenotype With Cerebellar Ataxia and Atrophy

(2013) G. Eda Utine et al.   JOURNAL OF CHILD NEUROLOGY

Early Onset of Ataxia in Moonwalker Mice Is Accompanied by Complete Ablation of Type II Unipolar Brush Cells and Purkinje Cell Dysfunction

(2013) G. Sekerkova et al.   JOURNAL OF NEUROSCIENCE

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans

(2013) L. B. Hills et al.   NEUROLOGY

New insights into behaviour using mouse ENU mutagenesis

(2012) P. L. Oliver et al.   HUMAN MOLECULAR GENETICS

The inherited ataxias: Genetic heterogeneity, mutation databases, and future directions in research and clinical diagnostics

(2012) Joshua Hersheson et al.   HUMAN MUTATION

Glutamate Receptor  2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase C , and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

(2012) A. S. Kato et al.   JOURNAL OF NEUROSCIENCE

Alternative Splicing of the TRPC3 Ion Channel Calmodulin/IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux

(2012) Y. Kim et al.   JOURNAL OF NEUROSCIENCE

Molecular and Cellular Control of Dendrite Maturation During Brain Development

(2012) F. Metzger   Current Molecular Pharmacology

Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias

(2011) Melissa A.C. Ingram et al.   BRAIN RESEARCH BULLETIN

Calcium as a Trigger for Cerebellar Long-Term Synaptic Depression

(2011) Elizabeth A. Finch et al.   CEREBELLUM

Candidate Screening of the TRPC3 Gene in Cerebellar Ataxia

(2011) Esther B. E. Becker et al.   CEREBELLUM

Update on degenerative ataxias

(2011) Thomas Klockgether   CURRENT OPINION IN NEUROLOGY

Genotype of an individual single nucleotide polymorphism regulates DNA methylation at theTRPC3alternative promoter

(2011) Alex Martin-Trujillo et al.   Epigenetics

P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje c

(2011) Olivia S. Gugger et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lack of Kinase Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channel-dependent Currents in Cerebellar Purkinje Cells

(2011) Charmaine Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

(2011) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

(2011) V. G. Shakkottai et al.   JOURNAL OF NEUROSCIENCE

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses instaggerermutant mice

(2011) Kazuhiro Mitsumura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Milestones in ataxia

(2011) Thomas Klockgether et al.   MOVEMENT DISORDERS

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes

(2011) M. Poteser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons

(2011) J. Hartmann et al.   Cold Spring Harbor Perspectives in Biology

Metabotropic Glutamate Receptor Type 1 Autoantibody–Associated Cerebellitis

(2010) Romain Marignier et al.   ARCHIVES OF NEUROLOGY

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling

(2010) M. Gees et al.   Cold Spring Harbor Perspectives in Biology

Animal Models of Human Cerebellar Ataxias: a Cornerstone for the Therapies of the Twenty-First Century

(2009) Mario Manto et al.   CEREBELLUM

Emerging pathogenic pathways in the spinocerebellar ataxias

(2009) Kerri M Carlson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cerebellar ataxias

(2009) Mario Manto et al.   CURRENT OPINION IN NEUROLOGY

Death and survival of heterozygous Lurcher Purkinje cellsIn vitro

(2009) Hadi S. Zanjani et al.   Developmental Neurobiology

Activation of native TRPC3 cation channels by phospholipase D

(2009) Maike D. Glitsch   FASEB JOURNAL

AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development

(2009) E. Bitoun et al.   JOURNAL OF NEUROSCIENCE

The puzzling role of TRPC3 channels in motor coordination

(2009) Mohamed Trebak   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

(2009) E. B. E. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+Homeostasis

(2008) Naoko Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells

(2008) Takahiro Seki et al.   NEUROBIOLOGY OF DISEASE

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON