Article
Cell & Tissue Engineering
Ruth Gussenhoven, Daan R. M. G. Ophelders, Jeroen Dudink, Kay Pieterman, Martin Lammens, Robert W. Mays, Luc J. Zimmermann, Boris W. Kramer, Tim G. A. M. Wolfs, Reint K. Jellema
Summary: This study demonstrated that early systemic MAPC therapy improved structural injury of the preterm cerebellum following global HI in a preclinical large animal model. Microstructural improvement was detectable with DTI. These findings support the potential of MAPC therapy for the treatment of HIE and the added clinical value of DTI for the detection of cerebellar injury and the evaluation of cell-based therapy.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ambra Costa, Davide Ceresa, Antonella De Palma, Rossana Rossi, Sara Turturo, Sara Santamaria, Carolina Balbi, Federico Villa, Daniele Reverberi, Katia Cortese, Pierangela De Biasio, Dario Paladini, Domenico Coviello, Silvia Ravera, Paolo Malatesta, Pierluigi Mauri, Rodolfo Quarto, Sveva Bollini
Summary: This study provides a detailed characterization of the total secretome and extracellular vesicles of human amniotic-fluid derived stem cells (hAFS), comparing fetal and perinatal cells. Both sources of cells offer formulations enriched with factors promoting regeneration, with fetal hAFS showing a more pronounced pro-vasculogenic and anti-aging profile. The study confirms that hAFS represent a promising source of regenerative paracrine factors for potential therapy consideration based on specific clinical scenarios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Manuel Rey-Funes, Daniela S. Contartese, Rafael Pelaez, Josune Garcia-Sanmartin, Judit Narro-Iniguez, Manuel Solino, Juan Carlos Fernandez, Anibal Sarotto, Nicolas S. Ciranna, Juan Jose Lopez-Costa, Veronica B. Dorfman, Ignacio M. Larrayoz, C. Fabian Loidl, Alfredo Martinez
Summary: Hypothermia has a protective effect on the retina in rat models of perinatal asphyxia, correcting abnormalities in electroretinogram and reducing retinal cell apoptosis. Expression of cold-shock proteins is upregulated in hypothermia treated groups, suggesting a potential mechanism for preventing vision disabling sequelae related to asphyxia.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anne Lee Solevag, Svetlana N. Zykova, Per Medboe Thorsby, Georg M. Schmolzer
Summary: Metabolomics plays a crucial role in assessing oxidative stress in perinatal asphyxia, with potential diagnostic and prognostic implications. While blood, plasma, and urine are commonly used for metabolomics analyses, the potential of saliva remains underexplored. Accumulating evidence supports the development of bedside methods to measure oxidative stress metabolites, with saliva as a candidate biofluid for point-of-care diagnostics.
Review
Biochemistry & Molecular Biology
Ryszard Pluta, Wanda Furmaga-Jablonska, Slawomir Januszewski, Agata Tarkowska
Summary: Perinatal asphyxia is a major cause of neurodegeneration in full-term newborns, leading to hypoxic-ischemic encephalopathy, which is the leading cause of mortality in term newborns. Despite the standard use of hypothermia, there is still a need for effective treatment strategies. Recent research suggests that melatonin, a natural compound with neuroprotective properties, may be used in the treatment of hypoxic-ischemic encephalopathy. However, clinical trials on a sufficient number of newborns have not yet been conducted, and further research is needed to explore the advantages and limitations of melatonin in perinatal asphyxia treatment.
Review
Endocrinology & Metabolism
Nicola Improda, Donatella Capalbo, Antonella Poloniato, Gisella Garbetta, Francesco Dituri, Laura Penta, Tommaso Aversa, Linda Sessa, Francesco Vierucci, Mariarosaria Cozzolino, Maria Cristina Vigone, Giulia Maria Tronconi, Marta del Pistoia, Laura Lucaccioni, Gerdi Tuli, Jessica Munarin, Daniele Tessaris, Luisa de Sanctis, Mariacarolina Salerno, ISPED
Summary: Perinatal asphyxia and hypothermia treatment can have significant effects on the endocrine system, including glucose and electrolyte disturbances, adrenal hemorrhage, and non-thyroidal illness syndrome. These abnormalities may impact both mortality and neurological outcomes. Hypothermia treatment may also disrupt endocrine balance and increase the risk of dilutional hyponatremia and hypercalcemia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
V. Cardozo, L. Vaamonde, A. Parodi-Talice, M. J. Zuluaga, D. Agrati, M. Portela, A. Lima, F. Blasina, F. Dajas, G. Bedo
Summary: Hypoxic-ischemic encephalopathy (HIE) leads to mortality and long-term neurologic morbidities in newborns, involving energy failure, excitotoxicity, and oxidative stress. Quercetin has been shown to have neuroprotective effects in perinatal asphyxia models, reducing mortality and affecting protein expression. The glycolytic pathway is strongly regulated by quercetin in both rat and piglet models, indicating potential neuroprotective mechanisms.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Obstetrics & Gynecology
Friederike Ott, Angela Kribs, Patrick Stelzl, Ioannis Kyvernitakis, Michael Ehlen, Susanne Schmidtke, Tamina Rawnaq-Mollers, Werner Rath, Richard Berger, Holger Maul
Summary: The authors propose that delayed umbilical cord clamping may benefit severely compromised and asphyctic term infants in need of resuscitation. The underlying pathophysiological mechanisms support this hypothesis, although there is limited evidence. Based on their analysis of available research, the authors conclude that immediately clamping the cord of asphyctic newborns may be unfavorable. Delayed cord clamping allows for fetoplacental transfusion of oxygenated venous blood and enhances blood volume, potentially buffering acidosis and compensating for hypoxemia or hypoxia. The timing of cord clamping affects the establishment of circulation in newborns. The authors raise the question of whether resuscitating compromised newborns with intact umbilical cords would be better, emphasizing the need for closer collaboration between obstetric and neonatal teams to improve neonatal outcomes.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Article
Pediatrics
Abdullah, Pratichi Kadam, Monika Yachha, Geetika Srivastava, Anish Pillai, Aakash Pandita
Summary: The study found that urinary B2mG levels can serve as an early predictive biomarker for AKI in term neonates with perinatal asphyxia.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Zhao-na Li, Shu-rong Wang, Ping Wang
Summary: A hospital-based study investigated the association between low birth weight (LBW) and perinatal asphyxia. The participants were mothers who gave birth in 2018. They were divided into case and control groups based on their children's asphyxia status. Bivariable and multivariable logistic regression were used to identify factors associated with perinatal asphyxia. The results showed a significant relationship between LBW, mother's age under 20 years, and gestational age with perinatal asphyxia.
Article
Medical Laboratory Technology
Valentina Botondi, Alice Pirra, Mariachiara Strozzi, Marika Perrotta, Danilo A. W. Gavilanes, Laura Di Ricco, Cynzia Spagnuolo, Antonio Maconi, Andrea Rocchetti, Laura Mazzucco, Valeria Balbo, Federico Schena, Giuseppina Stellitano, Arianna Oddi, Andrea Dotta, Iliana Bersani, Andrea Sannia, Chiara Peila, Enrico Bertino, Ines Bianco, Alessandra Gambi, Rocco Mangifesta, Diego Gazzolo
Summary: The objective of this study was to investigate the potential effects of perinatal asphyxia (PA) on presepsin (P-SEP) urine levels in infants. The results showed that PA had limited effects on P-SEP up to the first 24 hours after birth, without any bias in kidney function. These findings open the way for further research on validating P-SEP assessment as a reliable tool for early detection of early-onset sepsis (EOS) and late-onset sepsis (LOS) in high-risk infants.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daniel Mota-Rojas, Dina Villanueva-Garcia, Alfonso Solimano, Ramon Muns, Daniel Ibarra-Rios, Andrea Mota-Reyes
Summary: Perinatal asphyxia is a pathological condition caused by inadequate oxygen supply to internal organs, leading to hypoxic-ischemic encephalopathy as its clinical manifestation. The search for biomarkers and treatment strategies to predict the severity of lesions is ongoing, with hypothermia proving to be an effective neuroprotective strategy.
Article
Psychology, Multidisciplinary
Jianbo Liu, Yuqiong He, Yanmei Shen, Yuanyue Zhou, Tiantian Meng, Bo Xiao, Xilong Cui, Yumin Fang, Jianping Lu, Yu-Tao Xiang, Xuerong Luo
Summary: The study found that events occurring during pregnancy and perinatal period, such as threatened abortion and neonatal asphyxia, are associated with a higher risk of ADHD. Instrumental delivery and low birth weight were also identified as risk factors for ADHD among female students.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Pediatrics
Chiara Maddaloni, Domenico Umberto De Rose, Marco Perulli, Ludovica Martini, Iliana Bersani, Francesca Campi, Immacolata Savarese, Andrea Dotta, Maria Paola Ronchetti, Cinzia Auriti
Summary: This study compared the levels of presepsin in plasma and urine between newborn infants with perinatal asphyxia and controls. The results showed that the levels of presepsin in blood and urine were consistent in neonates with perinatal asphyxia at any time point. Additionally, perinatal asphyxia was found to increase the levels of serum CRP and procalcitonin.
Review
Medicine, General & Internal
Dimitra-Ifigeneia Matara, Abraham Pouliakis, Theodoros Xanthos, Rozeta Sokou, Georgios Kafalidis, Zoi Iliodromiti, Theodora Boutsikou, Nicoletta Iacovidou, Christos Salakos
Summary: This systematic review discusses the importance of the microbiome in the proper function of the gastrointestinal tract and overall wellbeing. The findings suggest that gut ischemia can disrupt the intestinal mucosal barrier and lead to bacterial translocation. Factors such as reduced blood oxygenation can cause intraluminal harmful factors to escape into the systemic circulation and transmit to distant organs and tissues, particularly in preterm neonates.
Review
Cell Biology
Kevin Zambrano, Diego Barba, Karina Castillo, Luis Noboa, Dariana Argueta-Zamora, Paola Robayo, Eduardo Arizaga, Andres Caicedo, Antonio W. D. Gavilanes
Summary: Parkinson's disease is a common neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the brain. Mitochondrial dysfunction, oxidative stress, and accumulation of alpha-synuclein contribute to the progression of PD. Recent evidence suggests that mitochondrial transfer/transplantation could be a potential therapeutic approach for PD.
Review
Cell Biology
Kevin Zambrano, Diego Barba, Karina Castillo, Paola Robayo, Eduardo Arizaga, Andres Caicedo, Antonio W. D. Gavilanes
Summary: Prion diseases are incurable neurodegenerative disorders caused by the misfolding and aggregation of infectious proteins. They rapidly induce tissue degeneration and death by clustering in the brain cells. Dysfunction of mitochondria, the powerhouse of cells, is a crucial element in the pathogenesis of prion diseases. Protecting mitochondria function and viability through antioxidants or artificial mitochondrial transfer/transplant may offer new therapeutic interventions in the fight against prion diseases.
Article
Critical Care Medicine
Killen H. Briones-Claudett, Monica H. Briones-Claudett, Mariuxi del Pilar Cabrera Banos, Killen H. Briones Zamora, Diana C. Briones Marquez, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Michelle Grunauer
Summary: This study compared the effectiveness of BiPAP.S/T-AVAPS with BiPAP.S/T mode in patients with mild-to-moderate de novo hypoxemic respiratory failure and found no significant differences in intubation rate and mortality between the two modes.
CRITICAL CARE RESEARCH AND PRACTICE
(2022)
Article
Medical Laboratory Technology
Iliana Bersani, Giorgia Gasparroni, Moataza Bashir, Hanna Aboulgar, Hala Mufeed, Iman Iskander, Maria Kornacka, Darek Gruzfeld, Andrea Dotta, Francesca Campi, Daniela Longo, Immacolata Savarese, Annabella Braguglia, Lucia Gabriella Tina, Francesco Nigro, Laura Serpero, Maria Chiara Strozzi, Antonio Maconi, Patrizia Ianniello, Caterina Di Battista, Ebe D'Adamo, Danilo Gavilanes, Diego Gazzolo
Summary: This study aimed to investigate the predictive role of urinary S100B concentrations in HIE infants compared to brain MRI. The results showed that high levels of S100B in urine were correlated with more severe MRI lesions. These findings support the reliability of S100B in clinical practice and suggest its potential inclusion in the selection of cases suitable for TH treatment.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Pediatrics
Francesco Cavigioli, Ilia Bresesti, Antonio Di Peri, Francesco Cerritelli, Diego Gazzolo, Antonio W. D. Gavilanes, Boris Kramer, Arjan te Pas, Gianluca Lista
Summary: This study aimed to verify the added value of respiratory function monitor in assessing ventilation and heart rate changes during stabilization of preterm infants. The results highlighted a clear correspondence between heart rate rise and adequate tidal volume per kilogram during stabilization. Respiratory function monitor may be useful in tailoring ventilation based on real-time changes in lung compliance.
PEDIATRIC PULMONOLOGY
(2023)
Article
Engineering, Civil
Omar Omar, Momen R. Mousa, Marwa Hassan, Ricardo Hungria, Andrea Gavilanes, Gabriel Arce, Jose Milla, Tyson Rupnow
Summary: Implementation of self-healing concrete technologies, such as bacterial concrete, is a promising approach to enhance the durability of transportation infrastructure. This study focuses on optimizing the healing efficiency of bacterial concrete in subtropical climates by vacuum impregnation of bacteria into a lightweight aggregate. Results showed that self-healing bacterial concrete could be optimized without significant reduction in mechanical properties by impregnating Bacillus pseudofirmus bacteria at a concentration of 10(8) cells/ml and sodium lactate precursor at a concentration of 75 mM/l into the lightweight aggregate.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Obstetrics & Gynecology
Francesco Cavigioli, Ilia Bresesti, Sara Gatto, Francesca Castoldi, Danilo Gavilanes, Diego Gazzolo, Massimo Agosti, Boris Kramer, Gianluca Lista
Summary: This study evaluated the short-term effects of different modes and settings of noninvasive respiratory support on gas exchange, breathing parameters, and thoracoabdominal synchrony in preterm infants with moderate respiratory distress syndrome. The results showed that there was no superiority of bilevel n-CPAP over n-CPAP, but nonsynchronized bilevel n-CPAP might be helpful when additional pressure is needed.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Endocrinology & Metabolism
Jaime Guevara-Aguirre, Arlan L. Rosenbloom, Alexandra Guevara, Mark A. Atkinson, MacKenzie D. Williams, Enrique Teran, Amanda L. Posgai, Carolina Guevara, Veronica Rosado, Antonio W. D. Gavilanes, Clive H. Wasserfall
Summary: This study examined the effect of growth hormone on carbohydrate metabolism and found that growth hormone is associated with diabetes development and the secretion of islet amyloid polypeptide (IAPP).
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Oncology
Jaime Guevara-Aguirre, Gabriela Pena, Gabriel Pazmino, William Acosta, Jannette Saavedra, Daniela Lescano, Alexandra Guevara, Antonio W. D. Gavilanes
Summary: Meta-analyses from 2018-2022 have shown that obesity increases the risk of various cancers. Obesity and its comorbidities are considered the largest and most lethal pandemics in history. Understanding the metabolic and hormonal mechanisms related to obesity and their impact on cancer development is crucial for addressing this global health threat.
ENDOCRINE-RELATED CANCER
(2023)
Article
Behavioral Sciences
Simone Tonetto, Pia Weikop, Tomasz Brudek, Morgane Thomsen
Summary: This study assessed the behavioral and neurochemical factors in two strains of mice to determine which one displayed clearer alcohol withdrawal symptoms and neurochemical alterations following re-exposure. The findings suggest that the B6 strain is suitable for studying the behavioral and neurochemical changes caused by alcohol withdrawal. The feasibility of these assays is important for understanding the long-lasting withdrawal symptoms that contribute to relapse in alcohol-dependent patients.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Marie Sonderstrup, Mykhailo Y. Batiuk, Panagiotis Mantas, Carles Tapias-Espinosa, Ignasi Oliveras, Toni Canete, Daniel Sampedro-Viana, Tomasz Brudek, Rasmus Rydbirk, Konstantin Khodosevich, Alberto Fernandez-Teruel, Betina Elfving, Susana Aznar
Summary: Disruption of brain development early in life may be involved in the neurobiology of schizophrenia, as evidenced by the findings of more immature synaptic spines in the frontal cortex of adult rats displaying schizophrenia-like traits. Transcriptome analysis revealed significant gene overrepresentation in synaptic function, and gene network analysis identified six networks that were significantly enriched in the schizophrenia-like rats, showing differential regulation during infancy and enrichment in biological ontologies related to myelination, synaptic function, and immune response. Differential gene expression validation in adolescent and young-adult rats further supported the aberrant synaptic maturation in the schizophrenia-like strain. These findings provide construct validity to this neurodevelopmental model.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sandra C. Sanchez-Zarza, Anastasia K. Armeni, Peter Chedraui, Faustino R. Perez-Lopez, Antonio W. D. Gavilanes
Summary: This study aimed to determine the prevalence of menopausal symptoms and factors related to severity in mid-aged women. The results showed that menopausal symptoms were related to hormonal, sexual and other female aspects.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Proceedings Paper
Construction & Building Technology
Andrea Gavilanes, Hassan Noorvand, Sujata Subedi, Marwa Hassan
Summary: This study evaluated the influence of cellulose nanocrystal (CNC) addition on the compressive strength of engineered cementitious composites (ECC). The results showed that adding 2.0 wt.% of CNC can improve the compressive strength of ECC.
Article
Endocrinology & Metabolism
Enrique Lopez Gavilanez, Manuel Navarro Chavez, Antonio W. D. Gavilanes, Roberto Cedeno German, Peter Chedraui
Summary: This study compared the incidence of hip fractures in older adults from Ecuador before and during the COVID-19 pandemic. The findings showed a significant reduction in the number of hip fractures during the period of social isolation, with no changes in hospital stay, mortality, and case-fatality rate.
ARCHIVES OF OSTEOPOROSIS
(2022)
Meeting Abstract
Critical Care Medicine
Michelle Grunauer, Caley Mikesell, Gabriela Bustamante, Kevin Zambrano, Andrea Icaza-Freire, Danielle Aronowitz, Antonio W. Danilo Gavilanes, Rafael Barrera
CRITICAL CARE MEDICINE
(2022)